삼출성 나이관련황반변성 환자와 당뇨황반부종 환자의 전방수 내 사이토카인 농도 분석
Analysis of Aqueous Humor Cytokines in Exudative Age-related Macular Degeneration and Diabetic Macular Edema
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목적: 삼출성 나이관련황반변성과 당뇨황반부종 환자의 전방수 내 사이토카인 농도를 분석하여 각 질환의 병인에 주요 기여를 하는사이토카인을 알아보고자 하였다. 대상과 방법: 총 57명을 대상으로 각 그룹당 19명씩 삼출성 나이관련황반변성, 당뇨황반부종, 정상 대조군 세 군으로 구분하였다. 각그룹당 전방 내 epidermal growth factor (EGF), vascular endothelial growth factor-C (VEGF-C), monocyte chemoattractant protein-1 (MCP-1), hepatocyte growth factor (HGF), interleukin (IL)-3, IL-8, IL-6, IL-12p40, intercellular adhesion molecule 1 (ICAM-1) 농도를 측정한 후 사이토카인 농도 비교를 위해 Kruskal-Wallis test, Mann-Whitney U test를 시행하였다. 결과: 삼출성 나이관련황반변성군과 대조군 비교에서는 EGF, VEGF-C, MCP-1, HGF, IL-3, IL-8이 삼출성 나이관련황반변성군에서유의하게 높게 나타났으며(p=<0.0001, <0.0001, 0.004, 0.015, <0.0001, 0.014), 당뇨황반부종군과 대조군 비교에서는 EGF, VEGF-C, IL-3, IL-8이 당뇨황반부종군에서 유의하게 높게 나타났다(p=<0.0001, <0.0001, <0.0001, 0.005). 삼출성 나이관련황반변성군과 당뇨황반부종군 비교에서는 EGF가 삼출성 나이관련황반변성군에서 유의하게 높게 나타났다(p=0.001). 결론: 다양한 사이토카인이 삼출성 나이관련황반변성 및 당뇨황반부종 환자에서 증가되어 있으며, 특히 EGF는 삼출성 나이관련황반변성 환자에서 당뇨황반부종 환자에 비해 높은 수치를 보인다.
Abstract
Purpose: To investigate the cytokine concentrations of aqueous humor in patients with exudative age-related macular degeneration (AMD) and diabetic macular edema (DME). Methods: Fifty-seven subjects were included in the exudative AMD, DME and control groups, each group has 19 patients. Aqueous levels of cytokines epidermal growth factor (EGF), vascular endothelial growth factor-C (VEGF-C), monocyte chemoattractant protein-1 (MCP-1), hepatocyte growth factor (HGF), interleukin (IL)-3, IL-8, IL-6, IL-12p40, intercellular adhesion molecule 1 (ICAM-1) were investigated in each groups. Kruskal-Wallis test and Mann-Whitney U test were performed to compare cytokine concentrations. Results: Aqueous levels of EGF, VEGF-C, MCP-1, HGF, IL-3, IL-8 were significantly higher in exudative AMD group than control group (p = < 0.0001, < 0.0001, 0.004, 0.015, < 0.0001, 0.014) and EGF, VEGF-C, IL-3, IL-8 were significantly higher in DME group than control group (p = < 0.0001, < 0.0001, < 0.0001, 0.005). In the comparison between the exudative AMD and DME groups, EGF was significantly higher in the exudative AMD group (p = 0.001). Conclusions: Various cytokines were increased in patients with exudative AMD and DME. In particular, EGF showed a higher level in exudative AMD than in DME.
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