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당뇨망막병증의 전방수내 사이토카인 분석

Analysis of Aqueous Humor Cytokines in Diabetic Retinopathy

김도균|정종현|송영진
대한안과학회 (The Korean Ophthalmological Society)|2014.12|대한안과학회지 (Journal of The Korean Ophthalmological Society)|제55권 제12호|pp. 1821-1827

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키워드

Diabetic retinopathyCytokineAqueous humor
주제분류안과학

초록

목적: 당뇨망막병증 환자의 전방수내 사이토카인 분석을 통해 당뇨망막병증의 정도에 따른 전방수내 사이토카인의 농도 변화에 대해알아보고자 한다. 대상과 방법: 총 36명을 대상으로 각 그룹당 12명씩 정상 대조군, 비증식당뇨망막병증, 증식당뇨망막병증 세 군으로 구분하였다. 세군 각각에서 전방 내 Interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, Vascular endothelial growth factor (VEGF),Monocyte chemoattractant protein-1 (MCP-1), Interferon-γ (INF-γ), Tumor necrosis factor-α (TNF-α)의 농도를 측정하였다. 결과: IL-6은 정상대조군과 증식당뇨망막병증군을 비교 시, 비증식당뇨망막병증군과 증식당뇨망막병증군을 비교 시 모두 증식당뇨망막병증군에서 전방 내 농도가 통계적으로 유의하게 높게 나타났다(p=0.016, p=0.003). VEGF는 정상 대조군보다 증식당뇨망막병증에서 전방 내 농도가 유의하게 높은 결과를 보였다(p=0.003). 그 외의 사이토카인들은 각 그룹 간에 통계적으로 유의한 차이를 보이지않았다. 결론: IL-6와 VEGF의 전방수내 농도는 정상 대조군에 비해서 증식당뇨망막병증에서 높은 수치를 보였다.

Abstract

Purpose: To investigate the relationship between the concentration of aqueous humor cytokines and the severity of diabeticretinopathy. Methods: Thirty-six subjects were included in the control, non-proliferative diabetic retinopathy (NPDR), and proliferative diabeticretinopathy (PDR) groups, each group has 12 patients. Aqueous levels of cytokines (interleukin (IL)-1α, IL-1β, IL-2, IL-4,IL-6, IL-8, IL-10, vascular endothelial growth factor (VEGF), monocyte chemoattractant protein (MCP)-1, interferon (IFN)-γ, tumornecrosis factor (TNF)-α) were investigated according to the severity of diabetic retinopathy. Results: When the control group was compared with the PDR and NPDR groups, aqueous levels of IL-6 were significantly higherin PDR patients than in those of both the control and NPDR groups (p = 0.016 and p = 0.003, respectively). The aqueous levelsof VEGF were significantly higher in the eyes of PDR patients than in those of the control group (p = 0.003). There were no statisticallysignificant differences between the 3 groups with regard to other cytokines. Conclusions: Aqueous levels of IL-6 and VEGF were higher in the eyes of PDR patients than in those of healthy controls.

참고문헌 (36)

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