당뇨망막병증 및 당뇨황반부종환자에서의 중증도에 따른 전방수내 사이토카인 상관관계 분석
Analysis of Intraocular Cytokines According to Progression of Diabetic Retinopathy and Macular Edema in Diabetic Patients
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목적: 당뇨망막병증 및 당뇨황반부종의 중증도에 따른 전방수내 사이토카인 분석을 통해 당뇨망막병증의 단계별 및 당뇨황반부종의중증도와 관련된 사이토카인의 변화를 알아보고자 하였다. 대상과 방법: 당뇨망막병증 중증도에 따라 4군으로 분류, 정상대조군 1군 포함, 총 70명을 대상으로 전방수내 Interleukin (IL)-6, 8, 10, 13,Monocyte chemoattractant protein-1 (MCP-1), Vascular endothelial growth factor (VEGF)의 농도 및 황반부종의 정도를 측정하였다. 결과: IL-6, 8, 10, MCP-1, VEGF는 당뇨망막병증 진행에 따라 증가하는 경향을 보여주었다. IL-13은 당뇨망막병증 환자에서 높아진경향을 보였지만 유의한 차이는 없었다. 황반두께와 IL-6, MCP-1, VEGF의 농도는 양의 상관관계를 보여주었다. 결론: 당뇨환자의 전방수내 사이토카인은 항염증성 인자인 IL-10, 13을 포함하여 정상 대조군에 비해 증가하였으며 IL-13을 제외한 모든인자들이 당뇨망막병증이 진행됨에 따라 증가하였다. 당뇨황반부종과 관련하여 IL-6, MCP-1, VEGF 등이 양의 상관관계를 보였다.
Abstract
Purpose: To investigate the relationship between the aqueous concentrations of cytokines, chemokine, VEGF and the severity of diabetic retinopathy and diabetic macular edema. Methods: Sixty eyes with diabetic retinopathy and diabetic macular edema, and 10 eyes of nondiabetic subjects were followed for 6 months. The aqueous levels of inflammatory and anti-inflammatory factors were measured. The aqueous levels of cytokines were investigated according to the severity of diabetic retinopathy and diabetic macular edema. Results: The aqueous levels of IL-6, IL-8, IL-10, MCP-1, and VEGF were elevated according to the severity of diabetic retinopathy. The aqueous levels of IL-13 were higher in eyes of diabetic patients than in eyes of nondiabetic subjects, but there were no statistically significant difference between diabetic retinopathy and nondiabetic subjects. The aqueous levels of IL-6, MCP-1, and VEGF were positively correlated with central macular thickness in eyes with diabetic macular edema. Conclusions: The aqueous levels of IL-6, IL-8, IL-10, MCP-1, and VEGF were correlated with the severity of diabetic retinopathy. The aqueous levels of IL-6, MCP-1, and VEGF were positively correlated with the severity of macular edema.
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