Comparison of enhancement and image quality: different iodine concentrations for liver on 128-slice multidetector computed tomography in the same chronic liver disease patients
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background/Aims: The objective of this study was to compare the degree of hepatic enhancement and image quality using contrast media of different iodine concentrations with the same iodine dose. Methods: From July 2011 to June 2013, 50 patients with chronic liver disease who underwent baseline and follow-up 128-slice multidetector computed tomography (MDCT) using contrast media with 350 mg I/mL (group A) and 400 mg I/mL (group B) iodine concentrations were included in this prospective study. The patients were randomly allocated to one of two protocols: 350 mg I/mL initially and then 400 mg I/mL; and 400 mg I/mL initially and then 350 mg I/mL. The bolus tracking technique was used to initiate the arterial phase scan. The computed tomography values of hepatic parenchyma, abdominal aorta and portal vein were measured. The degrees of hepatic and vascular enhancement were rated on a 4-point scale for qualitative assessment. The paired Student t test was used to compare outcome variables. Results: The mean hepatic enhancement was significantly higher in group B than in group A during the portal (p = 0.025) and equilibrium phases (p = 0.021). In all phases, group B had significantly higher mean liver-to-aorta contrast (p < 0.05) and mean visual scores for hepatic and vascular enhancement (p < 0.001). Conclusions: This study showed that a higher iodine concentration (400 mg I/ mL) in contrast media was more effective at improving hepatic enhancement in portal and equilibrium phase images and overall image quality using 128-slice MDCT in chronic liver disease patients
Abstract
Background/Aims: The objective of this study was to compare the degree of hepatic enhancement and image quality using contrast media of different iodine concentrations with the same iodine dose. Methods: From July 2011 to June 2013, 50 patients with chronic liver disease who underwent baseline and follow-up 128-slice multidetector computed tomography (MDCT) using contrast media with 350 mg I/mL (group A) and 400 mg I/mL (group B) iodine concentrations were included in this prospective study. The patients were randomly allocated to one of two protocols: 350 mg I/mL initially and then 400 mg I/mL; and 400 mg I/mL initially and then 350 mg I/mL. The bolus tracking technique was used to initiate the arterial phase scan. The computed tomography values of hepatic parenchyma, abdominal aorta and portal vein were measured. The degrees of hepatic and vascular enhancement were rated on a 4-point scale for qualitative assessment. The paired Student t test was used to compare outcome variables. Results: The mean hepatic enhancement was significantly higher in group B than in group A during the portal (p = 0.025) and equilibrium phases (p = 0.021). In all phases, group B had significantly higher mean liver-to-aorta contrast (p < 0.05) and mean visual scores for hepatic and vascular enhancement (p < 0.001). Conclusions: This study showed that a higher iodine concentration (400 mg I/ mL) in contrast media was more effective at improving hepatic enhancement in portal and equilibrium phase images and overall image quality using 128-slice MDCT in chronic liver disease patients
참고문헌 (30)
- Furuta A, "Hepatic enhancement in multiphasic contrast-enhanced MDCT: comparison of high- and low-iodine-concentration contrast medium in same patients with chronic liver disease", AJR Am J Roentgenol, 183, pp.157~162 (2004)
- Matoba M, "Depiction of hypervascular hepatocellular carcinoma with 64-MDCT: comparison of moderate- and high-concentration contrast material with and without saline flush", AJR Am J Roentgenol, 193, pp.738~744 (2009)
- Bae KT, "Peak contrast enhancement in CT and MR angiography:when does it occur and why? Pharmacokinetic study in a porcine model", Radiology, 227, pp.809~816 (2003)
- Hwang GJ, "Nodular hepatocellular carcinomas: detection with arterial-, portal-, and delayed-phase images at spiral CT", Radiology, 202, pp.383~388 (1997)
- Mitsuzaki K, "Multiple-phase helical CT of the liver for detecting small hepatomas in patients with liver cirrhosis:contrast-injection protocol and optimal timing", AJR Am J Roentgenol 1996;, 167, pp.753~757 (1996)
- Bae KT, "Aortic and hepatic peak enhancement at CT: effect of contrast medium injection rate: pharmacokinetic analysis and experimental porcine model", Radiology, 206, pp.455~464 (1998)
- Yamashita Y, "Abdominal helical CT: evaluation of optimal doses of intravenous contrast material: a prospective randomized study", Radiology, 216, pp.718~723 (2000)
- Awai K, "Aortic and hepatic enhancement and tumor-to-liver contrast: analysis of the effect of different concentrations of contrast material at multi-detector row helical CT", Radiology, 224, pp.757~763 (2002)
- Marchiano A, "Does iodine concentration affect the diagnostic efficacy of biphasic spiral CT in patients with hepatocellular carcinoma?", Abdom Imaging, 30, pp.274~280 (2005)
- Behrendt FF, "Intraindividual comparison of contrast media concentrations for combined abdominal and thoracic MDCT", AJR Am J Roentgenol, 191, pp.145~150 (2008)
- Tozaki M, "Dynamic contrast-enhanced MDCT of the liver: analysis of the effect of different iodine concentrations with the same total iodine dose in the same chronic liver disease patients", Radiat Med, 23, pp.533~538 (2005)
- Cademartiri F, "High iodine concentration contrast material for noninvasive multislice computed tomography coronary angiography:iopromide 370 versus iomeprol 400", Invest Radiol, 41, pp.349~353 (2006)
- Setty BN, "Comparison of enhancement, image quality, cost, and adverse reactions using 2 different contrast medium concentrations for routine chest CT on 16-slice MDCT", J Comput Assist Tomogr, 30, pp.818~822 (2006)
- Sultana S, "Evaluation of hypervascular hepatocellular carcinoma in cirrhotic liver by means of helical CT: comparison of different contrast medium concentrations within the same patient", Radiat Med, 21, pp.239~245 (2003)
- Tsurusaki M, "Multi-detector row helical CT of the liver: quantitative assessment of iodine concentration of intravenous contrast material on multiphasic CT: a prospective randomized study", Radiat Med, 22, pp.239~245 (2004)
- Bonaldi VM, "Helical CT of the liver: value of an early hepatic arterial phase", Radiology, 197, pp.357~363 (1995)
- Ito K, "Liver neoplasms: diagnostic pitfalls in cross-sectional imaging", Radiographics, 16, pp.273~293 (1996)
- Takayasu K, "CT diagnosis of early hepatocellular carcinoma: sensitivity, findings, and CT-pathologic correlation", AJR Am J Roentgenol, 164, pp.885~890 (1995)
- Cademartiri F, "Intravenous contrast material administration at helical 16-detector row CT coronary angiography: effect of iodine concentration on vascular attenuation", Radiology, 236, pp.661~665 (2005)
- Yanaga Y, "Optimal dose and injection duration (injection rate) of contrast material for depiction of hypervascular hepatocellular carcinomas by multidetector CT", Radiat Med, 25, pp.278~288 (2007)
- Sahani DV, "A comparison of the efficacy and safety of iopamidol-370 and iodixanol-320in patients undergoing multidetector-row computed tomography", Invest Radiol, 42, pp.856~861 (2007)
- Romano L, "Enhancement and safety of iomeprol-400 and iodixanol-320 in patients undergoing abdominal multidetector CT", Br J Radiol, 82, pp.204~211 (2009)
- Yagyu Y, "MDCT of hypervascular hepatocellular carcinomas: a prospective study using contrast materials with different iodine concentrations", AJR Am J Roentgenol, 184, pp.1535~1540 (2005)
- Fleischmann D, "Use of high concentration contrast media:principles and rationale-vascular district", Eur J Radiol, 45(Suppl 1), pp.S88~S93 (2003)
- Fleischmann D, "High-concentration contrast media in MDCT angiography: principles and rationale", Eur Radiol, 13(Suppl 3), pp.N39~N43 (2003)
- Sandstede JJ, "A prospective study comparing different iodine concentrations for triphasic multidetector row CT of the upper abdomen", Eur J Radiol, 60, pp.95~99 (2006)
- Han JK, "Factors influencing vascular and hepatic enhancement at CT: experimental study on injection protocol using a canine model", J Comput Assist Tomogr, 24, pp.400~406 (2000)
- Spielmann AL, "Liver imaging with MDCT and high concentration contrast media", Eur J Radiol, 45(Suppl 1), pp.S50~S52 (2003)
- Schoellnast H, "High-concentration contrast media in multiphasic abdominal multidetector-row computed tomography: effect of increased iodine flow rate on parenchymal and vascular enhancement", J Comput Assist Tomogr, 29, pp.582~587 (2005)
- Walkey MM, "Dynamic hepatic CT: how many years will it take ‘til we learn?", Radiology, 181, pp.17~18 (1991)