녹내장 유형에 따른 혈청 호모시스테인, 비타민 B12, 비타민 B6 및 엽산 농도의 비교
Comparison of Serum Homocysteine, Vitamin B12, Vitamin B6 and Folate Levels in Different Glaucoma Types
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목적: 정상안압녹내장, 거짓비늘녹내장 및 고안압성 개방각녹내장 환자의 혈청 호모시스테인, 비타민 B12, 비타민 B6 및 엽산 농도를비교하고자 하였다. 대상과 방법: 정상인 32명, 정상안압녹내장 환자 35명, 거짓비늘녹내장 환자 22명 및 고안압성 개방각녹내장 환자 31명을 대상으로공복 정맥혈을 채취한 후 혈청 호모시스테인, 비타민 B12, 비타민 B6 및 엽산 농도를 측정하였다. 네 군 간의 혈청 호모시스테인, 비타민 B12, 비타민 B6 및 엽산 농도를 일원배치 분산분석을 이용하여 비교하였다. 결과: 거짓비늘녹내장군과 고안압성 개방각녹내장군의 평균 호모시스테인 농도는 각각 17.91 ± 5.11, 17.60 ± 3.89 μmol/l로 대조군에비해 통계학적으로 유의하게 높았고(p=0.014, p=0.013), 거짓비늘녹내장군과 고안압성 개방각녹내장군의 평균 비타민 B6 농도는 각각 17.67 ± 14.32, 17.00 ± 10.58 nmol/l로 대조군에 비해 통계학적으로 유의하게 낮았다(p=0.026, p=0.008). 결론: 고호모시스테인혈증이 거짓비늘녹내장, 고안압성 개방각녹내장의 발생 또는 진행 기전에서 작용하는 위험인자로서의 가능성이있다.
Abstract
Purpose: To compare the levels of serum homocysteine, vitamin B12, vitamin B6 and folate in patients with normal-tension glaucoma, pseudoexfoliation glaucoma and high-tension glaucoma. Methods: Thirty-two healthy subjects, 35 patients with normal-tension glaucoma, 22 patients with pseudoexfoliation glaucoma and 31 patients with high-tension glaucoma were included in the present study. Fasting venous samples were collected from all the participants. The levels of serum homocysteine, vitamin B12, vitamin B6 and folate were measured. One-way analysis of variance was used for the comparison of homocysteine, vitamin B12, vitamin B6 and folate levels among the 4 groups. Results: The mean homocysteine levels in the pseudoexfoliation glaucoma and high-tension glaucoma group were 17.91± 5.11 and 17.60 ± 3.89 μmol/l, respectively, which were significantly higher than that of the control group (p = 0.014, p =0.013, respectively). The mean vitamin B6 levels in the pseudoexfoliation glaucoma and high-tension glaucoma group were 17.67 ± 14.32 and 17.00 ± 10.58 nmol/l, respectively, which were significantly lower than that of the control group (p = 0.026, p = 0.008, respectively). Conclusions: Hyperhomocysteinemia may play a role as a risk factor in the development or progression of pseudoexfoliation glaucoma and high-tension glaucoma.
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