당뇨망막병증 환자의 시야검사와 다국소망막전위도 검사의 상관관계
Correlation Between the Visual Field Test and Multifocal Electroretinogram in Patients with Diabetic Retinopathy
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목적: 당뇨망막병증 환자에서 다국소망막전위도 검사(mfERG)를 이용하여 황반부 기능을 평가하고, 시야검사(VF)의 역치와 비교하여상관관계를 알아보고자 한다. 대상과 방법: 당뇨망막병증 환자군 16명 16안과 대조군 14명 14안을 대상으로 후향적 연구를 시행하였다. mfERG와 VF는 황반중심으로부터 6도 간격으로 동심원 Ring 1, Ring 2, Ring 3를 구분하고, 각 영역의 진폭, 반응도달시간 및 역치를 구하여 상관관계를 분석하였다. 결과: 당뇨망막병증 환자군은 대조군에 비해 mfERG의 진폭은 모든 영역에서 감소하고, 반응도달시간은 Ring 2에서만 지연되며, VF의역치는 Ring 2와 Ring 3에서 의미있게 감소하였다(p＜0.05). 환자군에서 VF의 역치는 mfERG의 진폭과 Ring 2와 Ring 3에서 양의상관관계를 보였고, 반응도달시간은 Ring 3에서 음의 상관관계를 보였다(p＜0.05). 결론: 당뇨망막병증에서 mfERG의 진폭은 반응도달시간에 비해 VF의 역치와 더 유의한 상관관계를 보였다. VF와 더불어 mfERG도황반부 기능을 평가하는 유용한 검사이고, 두 검사를 동시에 시행한다면 조기에 정확한 황반부 기능 변화를 발견할 수 있을 것이다.
Abstract
Purpose: To evaluate the macular function by a multifocal electroretinogram (mfERG) in patients with diabetic retinopathy(DR), and to assess the correlation between responses of mfERG and the threshold of the visual field test (VF). Methods: The records of patients with DR (16 eyes, 16 patients) and control subjects (14 eyes, 14 subjects) were retrospectivelyreviewed. mfERG and VF were divided into Ring 1, Ring 2 and Ring 3 at 6-degree intervals from the centralmacula. The correlation between the amplitude/peak time and the threshold of each ring was analyzed. Results: In patients with DR, the amplitude was decreased in all areas, the peak time was delayed in Ring 2 and thethreshold was decreased in Rings 2 and 3, compared to control subjects. The amplitude of mfERG and the threshold of VFshowed statistically significant positive correlations in Rings 2 and 3 (p < 0.05). The peak time of mfERG and the thresholdof VF showed statistically significant negative correlations in Ring 3 (p < 0.05). Conclusions: The threshold of VF was more significantly correlated with the amplitude than with the peak time of mfERGin patients with DR. mfERG and VF were useful tests to assess the macular function, and alteration of macular functionwas early detected because two tests were conducted at the same time.
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