한국인 정상안 및 선천색각이상안에서 원뿔세포대비감도의 평가
Evaluation of the Cone Contrast Sensitivity Test in Normal Eyes and those with Congenital Color Blindness
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
목적: 한국인 정상안 및 선천색각이상안을 대상으로 새로운 색각검사인 원뿔세포대비감도검사(ColorDx Cone contrast test HD® [CCT-HD]; Konan Medical, Inc., Irvine, CA, USA)를 평가하고자 한다. 대상과 방법: 건강한 한국인 정상안 66명, 125안 및 선천색각이상안 25명, 50안을 대상으로 CCT-HD를 시행하였다. 정상안에서 양안검사 결과의 일치도 평가 및 연령대, 구면렌즈대응치에 따른 CCT-HD 결과 분석 및 선천색각이상안의 CCT-HD 결과와 비교 분석하였다. 결과: 정상안에서 양안의 장(L), 중(M), 단파장(S) 원뿔세포대비감도(L-CCT, M-CCT, S-CCT) 점수의 유의한 차이는 없었다. 또한 연령대에 따른 L, M 및 S-CCT 평균 점수의 유의한 차이는 없었고, 구면렌즈대응치와 각각의 CCT 점수 사이에 유의한 상관관계는 없었다. 정상안에서 L, M 및 S-CCT 점수는 모두 75점 이상이었다(정상 범위: ≥75점). 제1색각이상안의 평균 L-CCT 점수는 13.0 ± 13.2로 유의하게 낮았고(p<0.001), 제2색각이상안의 평균 M-CCT 점수는 31.7 ± 16.6으로 유의하게 낮았다(p<0.001). CCT-HD 검사의 L-CCT와 M-CCT는 각각 제1 및 2색각이상을 진단하는 데 100%의 민감도와 특이도를 보였다. 결론: CCT-HD 원뿔세포대비감도검사는 제1 및 2색각이상의 진단 및 분류에 새로운 색각검사 장비로써 유용할 것으로 기대된다.
Abstract
Purpose: We evaluated a new color vision test, thus the ColorDx Cone contrast test HD ([CCT-HD]; Konan Medical, Inc., Irvine, CA, USA) in normal and color vision-deficient (CVD) eyes of Koreans. Methods: The CCT-HD was performed on 66 healthy Koreans (125 normal eyes) and 25 patients (50 eyes) with congenital CVD. The results from normal eyes were compared and analyzed in terms of binocular agreement, patient ages, and spherical equivalents. The CCT-HD results on CVD eyes were compared and analyzed. Results: We found no significant difference in any of the long (L), medium (M), or short wavelength (S) cone cell sensitivity (L-CCT, M-CCT, S-CCT) scores for normal eyes; also, there was no significant effect of age and no significant correlation between the spherical equivalent and the CCT score. In normal eyes, all scores were >75 (normal ≥75). The average protan L-CCT score was significantly reduced (13.0 ± 13.2; p < 0.001) as was the average deutan M-CCT score (31.7 ± 16.6; p < 0.001). The CCT-HD L-CCT and M-CCT exhibited 100% sensitivity and specificity in terms of diagnosing protans and deutans respectively. Conclusions: CCT-HD allows classification and quantitative evaluation of protans and deutans, and is thus useful when examining color vision status.
참고문헌 (24)
- Porkony J, "Congenital and acquired color vision defects", pp.120~125 (1979), Grune & Stratton
- Um BS, "Eye Exam Vol. 1", pp.105~114 (2013), naewaehaksool
- Thompson DG, "Color blindness, a hazard to diabetics", Lancet, 1, pp.44~ (1978)
- Thompson DG, "Defective colour vision in diabetes : a hazard to management", Br Med J, 1, pp.859~860 (1979)
- Francois J, "Acquired dyschromatopsia", Ann Ocul(Paris), 190, pp.812~859 (1957)
- Pearson P, "Chromatic and achromatic defects in patients with progressing glaucoma", Vision Res, 41, pp.1215~1227 (2001)
- Nam MH, "Nagel's anomaloscope examination for subdivision of 100 cases of congenital color defects", J Korean Ophthalmol Soc, 21, pp.511~515 (1980)
- Rabin J, "Rapid quantification of color vision : the cone contrast test", Invest Ophthalmol Vis Sci, 52, pp.816~820 (2011)
- Fujikawa M, "Evaluation of clinical validity of the Rabin cone contrast test in normal phakic or pseudophakic eyes and severely dichromatic eyes", Acta Ophthalmol, 96, pp.e164~e167 (2018)
- Rucker FJ, "Cone contributions to signals for accommodation and the relationship to refractive error", Vision Res, 46, pp.3079~3089 (2006)
- Operational Based Vision Assessment Cone Contrast Test: Description and Operation, "Gaska J", Defense Technical Information Center, 19~, pp.Report No.: ADA635957 (2016)
- Swanson WH, "Color vision", Ophthalmol Clin North Am, 16, pp.179~203 (2003)
- Rabin J, "Cone-specific measures of human color vision", Invest Ophthalmol Vis Sci, 37, pp.2771~2774 (1996)
- Niwa Y, "Evaluation of acquired color vision deficiency in glaucoma using the Rabin cone contrast test", Invest Ophthalmol Vis Sci, 55, pp.6686~6690 (2014)
- Cocce KJ, "Visual function endpoints in early and intermediate dry age-related macular degeneration for use as clinical trial endpoints", Am J Ophthalmol, 189, pp.127~138 (2018)
- Foster DH, "Inherited and Acquired Color Vision Deficiencies: fundamental aspects and clinical studies", pp.32~45 (1991), CRC Press
- Cooper H, "Application of a LaserJet printer to plot the Farnsworth-Munsell 100-hue color test", Optom Vis Sci, 67, pp.372~376 (1990)
- Smith VC, "Color-axis determination on the Farnsworth-Munsell 100-hue test", Am J Ophthalmol, 100, pp.176~182 (1985)
- Birch J, "Uses of the Farnsworth-Munsell 100-Hue test in the examination of congenital colour vision defects", Ophthalmic Physiol Opt, 9, pp.156~162 (1989)
- Kim MS, "Seohan Computerized Hue Test(1) : The development of computerized color vision test and pilot study", J Korean Ophthalmol Soc, 41, pp.205~214 (2000)
- 김민섭, "서한전산화색각검사(2): 정상인에서의 연령별 총오점수와 색각이상자에서의 총오점수 및 중심값 분석", 대한안과학회지, 42(3), pp.453~458 (2001), 대한안과학회
- 신영주, "서한전산화색각검사를 이용한 색상보정프로그램의 유효성", 대한안과학회지, 47(10), pp.1638~1646 (2006), 대한안과학회
- 신영주, "SNU 전산화 색각검사를 이용한 선천색각이상자의 분류", 대한안과학회지, 45(12), pp.21~21 (2004), 대한안과학회
- de Fez D, "New iPAD-based test for the detection of color vision deficiencies", Graefes Arch Clin Exp Ophthalmol, 256, pp.2349~2360 (2018)