고삼과 애엽의 발효 혼합물이 에탄올과 니코틴으로 유발된 마우스 대식세포 내 hydrogen peroxide 생성감소에 미치는 영향
Effect of Mixture of Fermented Artemisiae Argi Folium and Fermented Sophorae Radix on Hydrogen Peroxide Production within Mouse Macrophage Raw 264.7 with EtOH and Nicotine
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초록
The purpose of this study is to investigate the effect of a mixture of fermented Artemisiae Argi Folium and fermented Sophorae Radix (FAS) on hydrogen peroxide production within mouse macrophage Raw 264.7 with ethanol (EtOH) and nicotine. Artemisiae Argi Folium is known to have the antibacterial, immune-enhancing properties. And Sophorae Radix is also known to have the antibacterial, anti-inflammatory, anti-allergic properties. EtOH and nicotine are the ones of toxicants which could impair immunocytes like macrophage. EtOH and nicotine reduce the intracellular production of hydrogen peroxide (H2O2) of Raw 264.7. FAS increased the production of hydrogen peroxide reduced by EtOH and nicotine within Raw 264.7. These results indicate that FAS could restore the immuno-activity of macrophage impaired by EtOH and nicotine.
Abstract
The purpose of this study is to investigate the effect of a mixture of fermented Artemisiae Argi Folium and fermented Sophorae Radix (FAS) on hydrogen peroxide production within mouse macrophage Raw 264.7 with ethanol (EtOH) and nicotine. Artemisiae Argi Folium is known to have the antibacterial, immune-enhancing properties. And Sophorae Radix is also known to have the antibacterial, anti-inflammatory, anti-allergic properties. EtOH and nicotine are the ones of toxicants which could impair immunocytes like macrophage. EtOH and nicotine reduce the intracellular production of hydrogen peroxide (H2O2) of Raw 264.7. FAS increased the production of hydrogen peroxide reduced by EtOH and nicotine within Raw 264.7. These results indicate that FAS could restore the immuno-activity of macrophage impaired by EtOH and nicotine.
참고문헌 (28)
- 전국한의과대학 공동교재편찬위원회, "본초학", pp.185~186 (1991), 서울, 영림사
- 전국한의과대학 공동교재편찬위원회, "본초학", pp.405~407 (1991), 서울, 영림사
- 정용준, "발효한약추출물 HP-1이 알코올을 투여한 쥐의 알코올 대사에 미치는 영향", 동의생리병리학회지, 21(2), pp.387~391 (2007), 대한동의병리학회
- 조수인, "동백 발효 추출물 단기 투여의 활성에 대한 연구", 대한본초학회지, 21(2), pp.55~62 (2006), 대한본초학회
- 최혁재, "발효강화쑥의 간장해 보호효과", 생약학회지, 38(3), pp.245~253 (2007), 한국생약학회
- Figliomeni, M.L., "Developmental immunotoxicity of cocaine and ethanol in postnatal Lewis rats", Immunopharmacology, 36(1), pp.41~48 (1997)
- McMaster, S.K., "Br J Pharmacol", Br J Pharmacol, 153(3), pp.536~543 (2008)
- Jirapongsananuruk, O., "Diagnostic paradigm for evaluation of male patients with chronic granulomatous disease, based on the dihydrorhodamine 123 assay", J Allergy Clin Immunol, 111(2), pp.374~379 (2003)
- Richardson, M.P., "A simple flow cytometry assay using dihydrorhodamine for the measurement of the neutrophil respiratory burst in whole blood: comparison with the quantitative nitrobluetetrazolium test", J Immunol Methods, 219(1-2), pp.187~193 (1998)
- Crow, J.P., "Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen species", Nitric Oxide, 1(2), pp.145~157 (1997)
- van Pelt. L.J., "Limitations on the use of dihydrorhodamine 123 for flow cytometric analysis of the neutrophil respiratory burst", J Immunol Methods, 191(2), pp.187~196 (1996)
- Roesler, J., "Diagnosis of chronic granulomatous disease and of its mode of inheritance by dihydrorhodamine 123 and flow microcytofluorometry", Eur J Pediatr, 150(3), pp.161~165 (1991)
- 정경희, "BV2 microglial cells에서 ERK를 통한 고삼의 Tnf alpha 생성 억제효과", 대한본초학회지, 22(2), pp.147~153 (2007), 대한본초학회
- 이현옥, "고삼으로부터 항우식활성 물질의 분리", 한국미생물·생명공학회지, 30(4), pp.420~424 (2002), 한국미생물·생명공학회
- 권강범, "고삼 추출물이 XO", HX에 의해 손상된 혈관내피세포에 미치는 영향(I), 2003, pp.17(2), 549~552[DOI]
- 이현옥, "고삼의 Streptococcus mutans에 대한 항세균 효과", 한국식품영양학회지, 13(6), pp.539~546 (2000)
- 김호철, "한약약리학", pp.309~311 (2001), 서울, 집문당
- Kim, M.J., "Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species", Ann N Y Acad Sci, 1095, pp.483~495 (2007)
- Jeong, M.A., "Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells", Ann N Y Acad Sci, 1095, pp.458~466 (2007)
- Lee, H.G., "Inhibitory effect of jaceosidin isolated from Artemisiaargyi on the function of E6 and E7 oncoproteins of HPV 16", J Ethnopharmacol, 98(3), pp.339~343 (2005)
- Adams, M., "Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM", ADR5000 cells, from Artemisia argyi, 2006, pp.72(9), 862~864
- 정대영, "황해쑥 물분획물의 L1210세포에 대한 세포독성과 항산화 효소활성변화", 약 학 회 지, 46(1), pp.39~46 (2002), 대한약학회
- 김경하, "황해쑥(Artemisia argyi)의 열수 및 메탄올 추출액은 H9(ATCC HTB176)세포에 대한 세포독성 및 항산화효소 활성", 약학회지, 43(5), pp.598~605 (1999)
- Gelderman, K.A., "Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species", J Clin Invest, 117(10), pp.3020~3028 (2007)
- Gelderman, K.A., "Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies", Antioxid Redox Signal, 9(10), pp.1541~1567 (2007)
- Hultqvist, M., "Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in mice", J Immunol, 179(3), pp.1431~1437 (2007)
- Hultqvist, M., "A new arthritis therapy with oxidative burst inducers", PLoS Med, 3(9), pp.E348~ (2006)
- Hultqvist, M., "Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice", Cell Immunol, 233(2), pp.97~101 (2005)
