Trends of Sensitization to Inhalant Allergens in Korean Children Over the Last 10 Years
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Purpose: Climate and lifestyle changes increase an individual’s susceptibility to various allergens and also the incidence of allergicdiseases. We aimed to examine the changes in sensitization rate for aeroallergens over a 10-year period in Korean children. Materials and Methods: We retrospectively reviewed the medical records of 4493 children who visited the allergy clinic at a tertiaryhospital in Korea for allergic rhinitis or asthma from January 2009 to December 2018. The serum specific immunoglobulin E(IgE) levels were measured to confirm the sensitization against Dermatophagoides farinae (D. farinae), Alternaria, weed and treepollen mixtures, as well as cat and dog dander through ImmunoCAP test. Results: D. farinae was the most common sensitizing aeroallergen (45.9%) during the 10-year span. The sensitization rate for treepollen mixture (p for trend <0.001), weed pollen mixtures (p for trend <0.001), dog dander (p for trend=0.025), and cat dander (p fortrend=0.003) showed ascending trends during the 10-year study period. Furthermore, the sensitization rate for multiple allergens(≥2) in 2018 increased significantly compared to that in 2009 (p for trend=0.013). Compared with children without sensitization toD. farinae, those with sensitization to D. farinae showed higher sensitization rates to other aeroallergens (p for interaction <0.001). Conclusion: Children’s sensitization rate to cat and dog dander and weed and tree pollen mixtures significantly increased duringthe 10-year period in Korea. Children with sensitization to D. farinae are likely to be sensitized to other aeroallergens as well.
Abstract
Purpose: Climate and lifestyle changes increase an individual’s susceptibility to various allergens and also the incidence of allergicdiseases. We aimed to examine the changes in sensitization rate for aeroallergens over a 10-year period in Korean children. Materials and Methods: We retrospectively reviewed the medical records of 4493 children who visited the allergy clinic at a tertiaryhospital in Korea for allergic rhinitis or asthma from January 2009 to December 2018. The serum specific immunoglobulin E(IgE) levels were measured to confirm the sensitization against Dermatophagoides farinae (D. farinae), Alternaria, weed and treepollen mixtures, as well as cat and dog dander through ImmunoCAP test. Results: D. farinae was the most common sensitizing aeroallergen (45.9%) during the 10-year span. The sensitization rate for treepollen mixture (p for trend <0.001), weed pollen mixtures (p for trend <0.001), dog dander (p for trend=0.025), and cat dander (p fortrend=0.003) showed ascending trends during the 10-year study period. Furthermore, the sensitization rate for multiple allergens(≥2) in 2018 increased significantly compared to that in 2009 (p for trend=0.013). Compared with children without sensitization toD. farinae, those with sensitization to D. farinae showed higher sensitization rates to other aeroallergens (p for interaction <0.001). Conclusion: Children’s sensitization rate to cat and dog dander and weed and tree pollen mixtures significantly increased duringthe 10-year period in Korea. Children with sensitization to D. farinae are likely to be sensitized to other aeroallergens as well.
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