일측성 만성 이명 환자에서 1회 경두개 자기장 치료의 단기 효과
Short-Term Effect of Single Session Repetitive Transcranial Magnetic Stimulation in Chronic Unilateral Tinnitus
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초록
Background and Objectives The repetitive Transcranial Magnetic Stimulation (rTMS) is generally performed over the course of several weeks, as its theoretical and experimental validity has been identified in repetitive procedures. If short term application of rTMS is proven to be significantly effective, more effective treatment of tinnitus can be expected. This study was conducted to measure the effect of one session of sham rTMS & one real trial of rTMS in chronic unilateral tinnitus patients. Subjects and Method rTMS stimulation of 1 Hz and 100% magnitude was given 1200 times per day to 33 patients with chronic unilateral tinnitus on their left side, between T3 and C3/T5, following the convention of the 10-20 International EEG system. Visual Analogue Scale (VAS) and Tinnitus Handicap Inventory (THI) scores were measured four times-immediately before rTMS, immediately after sham rTMS, immediately after real rTMS and two weeks after real rTMS. Results VAS and THI scores were found to show a tendency of declining. Immediately after real rTMS application, a significant decrease in VAS and THI scores was observed compared to those measured immediately before rTMS (p＜0.05). The longer the duration was, the smaller the changes in THI and VAS scores were after a single session of rTMS treatment, a finding that is statistically significant (p＜0.05). No significant changes in THI and VAS scores (p＞0.05) attributable to the direction of tinnitus were observed. Conclusion A single session rTMS is thought to be a possible adjunctive treatment for tem-porary relief of tinnitus.
Abstract
Background and Objectives The repetitive Transcranial Magnetic Stimulation (rTMS) is generally performed over the course of several weeks, as its theoretical and experimental validity has been identified in repetitive procedures. If short term application of rTMS is proven to be significantly effective, more effective treatment of tinnitus can be expected. This study was conducted to measure the effect of one session of sham rTMS & one real trial of rTMS in chronic unilateral tinnitus patients. Subjects and Method rTMS stimulation of 1 Hz and 100% magnitude was given 1200 times per day to 33 patients with chronic unilateral tinnitus on their left side, between T3 and C3/T5, following the convention of the 10-20 International EEG system. Visual Analogue Scale (VAS) and Tinnitus Handicap Inventory (THI) scores were measured four times-immediately before rTMS, immediately after sham rTMS, immediately after real rTMS and two weeks after real rTMS. Results VAS and THI scores were found to show a tendency of declining. Immediately after real rTMS application, a significant decrease in VAS and THI scores was observed compared to those measured immediately before rTMS (p＜0.05). The longer the duration was, the smaller the changes in THI and VAS scores were after a single session of rTMS treatment, a finding that is statistically significant (p＜0.05). No significant changes in THI and VAS scores (p＞0.05) attributable to the direction of tinnitus were observed. Conclusion A single session rTMS is thought to be a possible adjunctive treatment for tem-porary relief of tinnitus.
참고문헌 (25)
- Lockwood AH, "Tinnitus", N Engl J Med, 347(12), pp.904~910 (2002)
- 이승준, "노인 환자에서 이명에 대한 주파수 분석과 난청과의 관계", 대한이비인후과학회지 두경부외과학, 50(10), pp.869~875 (2007), 대한이비인후과학회
- Londero A, "Repetitive transcranial magnetic stimulation (rTMS): a new therapeutic approach in subjective tinnitus?", Neurophysiol Clin, 36(3), pp.145~155 (2006)
- Dobie RA, "A review of randomized clinical trials in tinnitus", Laryngoscope, 109(8), pp.1202~1211 (1999)
- 한병인, "Tinnitus: Characteristics, Causes, Mechanisms, and Treatments", Journal of Clinical Neurology, 5(1), pp.11~19 (2009), 대한신경과학회
- Moller AR, "Similarities between severe tinnitus and chronic pain", J Am Acad Audiol, 11(3), pp.115~124 (2000)
- Kaltenbach JA, "Neurophysiologic mechanisms of tinnitus", J Am Acad Audiol, 11(3), pp.125~137 (2000)
- Cacace AT, "Cutaneous-evoked tinnitus. I. Phenomenology, psychophysics and functional imaging", Audiol Neurootol, 4(5), pp.247~257 (1999)
- Penner MJ, "An estimate of the prevalence of tinnitus caused by spontaneous otoacoustic emissions", Arch Otolaryngol Head Neck Surg, 116(4), pp.418~423 (1990)
- Hall DA, "Treatment options for subjective tinnitus: self reports from a sample of general practitioners and ENT physicians within Europe and the USA", BMC Health Serv Res, 11, pp.302~ (2011)
- De Ridder D, "Primary and secondary auditory cortex stimulation for intractable tinnitus", ORL J Otorhinolaryngol Relat Spec, 68(1), pp.48~55 (2006)
- De Ridder D, "Transcranial magnetic stimulation for tinnitus: influence of tinnitus duration on stimulation parameter choice and maximal tinnitus suppression", Otol Neurotol, 26(4), pp.616~619 (2005)
- Bohning DE, "Introduction and overview of TMS physics, In Transcranial magnetic stimulation in neu-ropsychiatry", pp.13~44 (2000), American Psychiatric Press
- Holgers KM, "Predictive factors for development of severe tinnitus suffering-further characterisation", Int J Audiol, 44(10), pp.584~592 (2005)
- Rossiter S, "Tinnitus and its effect on working memory and attention", J Speech Lang Hear Res, 49(1), pp.150~160 (2006)
- Folmer RL, "Tinnitus and insomnia", Am J Otolaryngol, 21(5), pp.287~293 (2000)
- Reynolds P, "Tinnitus and psychological morbidity: a cross-sectional study to investigate psychological morbidity in tinnitus patients and its relationship with severity of symptoms and illness perceptions", Clin Otolaryngol Allied Sci, 29(6), pp.628~634 (2004)
- deoxyglu cose, "ORL J Otorhinolaryngol Relat Spec", 1996, 195~199
- Kleinjung T, "Long-term effects of repetitive transcranial magnetic stimulation (rTMS) in patients with chronic tinnitus", Otolaryngol Head Neck Surg, 132(4), pp.566~569 (2005)
- Langguth B, "The impact of auditory cortex activity on characterizing and treating patients with chronic tinnitus--first results from a PET study", Acta Otolaryngol Suppl, (556), pp.84~88 (2006)
- Lockwood AH, "The functional anatomy of gaze-evoked tinnitus and sustained lateral gaze", Neurology, 56(4), pp.472~480 (2001)
- Mirz F, "Cortical networks subserving the perception of tinnitus--a PET study", Acta Otolaryngol Suppl, 543, pp.241~243 (2000)
- Frank G, "Left temporal low-frequency rTMS for the treatment of tinnitus: clinical predictors of treatment outcome--a retrospective study", Eur J Neurol, 17(7), pp.951~956 (2010)
- Minami SB, "Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus", Auris Nasus Larynx, 38(3), pp.301~306 (2011)
- Kleinjung T, "Which tinnitus patients benefit from transcranial magnetic stimulation?", Otolaryngol Head Neck Surg, 137(4), pp.589~595 (2007)