Short Term Effects of Repetitive Transcranial Magnetic Stimulation in Patients with Catastrophic Intractable Tinnitus: Preliminary Report
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives. The short-term effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) in the patients withcatastrophic and intractable tinnitus were investigated. Methods. Fifteen participants were recruited among patients with catastrophic intractable tinnitus to receive 1 Hz rTMStreatment. Tinnitus severity was assessed before rTMS and directly after sham or real rTMS using the tinnitus handicapinventory (THI) and visual analog scale (VAS). Results. There was no statistical difference in the THI score before and after sham stimulation. However, after 5 replicationsof real rTMS there was statistically significant reduction in THI score. Eight patients showed a decrease of more than10 in THI score. Patients who showed a vast change in THI score after rTMS also showed a large decrease in their VASscore (r=0.879, P<0.001). Duration of tinnitus and change of THI score showed statistically significant moderatenegative correlation (r=-0.637, P=0.011). But in case of VAS, there was no significant difference between VAS andduration of tinnitus. Conclusion. Among total 15 patients with catastrophic intractable chronic tinnitus, eight patients showed some improvementin symptoms after 1 Hz rTMS. rTMS can be considered management modality for intractable tinnitus evenwith distress as severe as catastrophic stage.
Abstract
Objectives. The short-term effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) in the patients withcatastrophic and intractable tinnitus were investigated. Methods. Fifteen participants were recruited among patients with catastrophic intractable tinnitus to receive 1 Hz rTMStreatment. Tinnitus severity was assessed before rTMS and directly after sham or real rTMS using the tinnitus handicapinventory (THI) and visual analog scale (VAS). Results. There was no statistical difference in the THI score before and after sham stimulation. However, after 5 replicationsof real rTMS there was statistically significant reduction in THI score. Eight patients showed a decrease of more than10 in THI score. Patients who showed a vast change in THI score after rTMS also showed a large decrease in their VASscore (r=0.879, P<0.001). Duration of tinnitus and change of THI score showed statistically significant moderatenegative correlation (r=-0.637, P=0.011). But in case of VAS, there was no significant difference between VAS andduration of tinnitus. Conclusion. Among total 15 patients with catastrophic intractable chronic tinnitus, eight patients showed some improvementin symptoms after 1 Hz rTMS. rTMS can be considered management modality for intractable tinnitus evenwith distress as severe as catastrophic stage.
참고문헌 (26)
- Jastreboff PJ, "Phantom auditory perception (tinnitus): mechanisms of generation and perception", Neurosci Res, 8(4), pp.221~254 (1990)
- Andersson G, "A meta-analytic review of psychological treatments for tinnitus", Br J Audiol, 33(4), pp.201~210 (1999)
- Zoger S, "Relationship between tinnitus severity and psychiatric disorders", Psychosomatics, 47(4), pp.282~288 (2006)
- deoxyglucose, "ORL J Otorhinolaryngol Relat Spec", 1996, 195~199
- Schlee W, "Abnormal resting-state cortical coupling in chronic tinnitus", BMC Neurosci, 10, pp.11~ (2009)
- Lanting CP, "Neural activity underlying tinnitus generation: results from PET and fMRI", Hear Res, 255(1-2), pp.1~13 (2009)
- Langguth B, "rTMS for the treatment of tinnitus: the role of neuronavigation for coil positioning", Neurophysiol Clin, 40(1), pp.45~58 (2010)
- Bohning DE, "Introduction and overview of TMS physics, In Transcranial magnetic stimulation in neuropsychiatry", pp.13~44 (2000), American Psychiatric Press
- Hoffman RE, "Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders", Am J Psychiatry, 159(7), pp.1093~1102 (2002)
- Frank G, "Left temporal low-frequency rTMS for the treatment of tinnitus: clinical predictors of treatment outcome-a retrospective study", Eur J Neurol, 17(7), pp.951~956 (2010)
- Langguth B, "Controversy: does repetitive transcranial magnetic stimulation", transcranial direct current stimulation show efficacy in treating tinnitus patients?, 2008, pp.1(3), 192~205
- Dobie RA, "A review of randomized clinical trials in tinnitus", Laryngoscope, 109(8), pp.1202~1211 (1999)
- Jastreboff PJ, "Tinnitus retraining therapy: a different view on tinnitus", ORL J Otorhinolaryngol Relat Spec, 68(1), pp.23~30 (2006)
- Londero A, "Contribution of cognitive and behavioral therapy for patients with tinnitus: implication in anxiety and depression", Ann Otolaryngol Chir Cervicofac, 121(6), pp.334~345 (2004)
- Moller AR, "Pathophysiology of tinnitus", Otolaryngol Clin North Am, 36(2), pp.249~266 (2003)
- Eggermont JJ, "Pathophysiology of tinnitus", Prog Brain Res, 166, pp.19~35 (2007)
- Piccirillo JF, "Low-frequency repetitive transcranial magnetic stimulation to the temporoparietal junction for tinnitus", Arch Otolaryngol Head Neck Surg, 137(3), pp.221~228 (2011)
- Marcondes RA, "Repetitive transcranial magnetic stimulation improve tinnitus in normal hearing patients: a double-blind controlled, clinical and neuroimaging outcome study", Eur J Neurol, 17(1), pp.38~44 (2010)
- Kleinjung T, "Long-term effects of repetitive transcranial magnetic stimulation (rTMS) in patients with chronic tinnitus", Otolaryngol Head Neck Surg, 132(4), pp.566~569 (2005)
- De Ridder D, "Transcranial magnetic stimulation for tinnitus: influence of tinnitus duration on stimulation parameter choice and maximal tinnitus suppression", Otol Neurotol, 26(4), pp.616~619 (2005)
- Khedr EM, "One-year follow up of patients with chronic tinnitus treated with left temporoparietal rTMS", Eur J Neurol, 16(3), pp.404~408 (2009)
- Langguth B, "The impact of auditory cortex activity on characterizing and treating patients with chronic tinnitus: first results from a PET study", Acta Otolaryngol Suppl, (556), pp.84~88 (2006)
- Smits M, "Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus", Neuroradiology, 49(8), pp.669~679 (2007)
- Kleinjung T, "Which tinnitus patients benefit from transcranial magnetic stimulation?", Otolaryngol Head Neck Surg, 137(4), pp.589~595 (2007)
- Londero A, "Repetitive transcranial magnetic stimulation (rTMS): a new therapeutic approach in subjective tinnitus?", Neurophysiol Clin, 36(3), pp.145~155 (2006)
- Rossi S, "Effects of repetitive transcranial magnetic stimulation on chronic tinnitus: a randomised, crossover, double blind, placebo controlled study", J Neurol Neurosurg Psychiatry, 78(8), pp.857~863 (2007)