Combined Bifrontal Transcranial Direct Current Stimulation and Tailor-Made Notched Music Training in Chronic Tinnitus
1
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
Background and Objectives: We evaluated the short-term treatment outcomes of combined bifrontal transcranial direct current stimulation (tDCS) and tailor-made notched music training (TMNMT) in tinnitus patients. The associations of patient characteristics with treatment responsiveness were investigated. Subjects and Methods: Four sessions of bifrontal tDCS (F4: anode, F3: cathode) and TMNMT were conducted over a 2-week period in tinnitus patients. For tDCS, the stimulation intensity was 1.5 mA and the duration was approximately 20 min. During tDCS, patients listened to music lacking the frequency band within 1 octave of the tinnitus frequency. Patients were also instructed to listen to this music at home for at least 2 hours per day. One month after the final tDCS session, loudness (LD), awareness (AW), annoyance (AN), and effect on life (EL) of tinnitus were assessed subjectively using a visual analog scale. Results: A total of 14 patients were enrolled in this study. After treatment, a 50% or greater improvement in AN, AW, EL, and LD was observed in 57.1, 42.9, 35.7, and 28.6% of patients, respectively. Furthermore, 78.6% of patients showed a 50% or greater improvement in their tinnitus handicap inventory scores. For AN, the absence of sleep disturbance was significantly associated with treatment responsiveness (p=0.041, OR=24.0). Conclusions: Combined bifrontal tDCS and TMNMT is a promising treatment for chronic tinnitus. To maximize the treatment outcomes of this therapy, sleep disturbances should also be addressed in candidate patients.
Abstract
Background and Objectives: We evaluated the short-term treatment outcomes of combined bifrontal transcranial direct current stimulation (tDCS) and tailor-made notched music training (TMNMT) in tinnitus patients. The associations of patient characteristics with treatment responsiveness were investigated. Subjects and Methods: Four sessions of bifrontal tDCS (F4: anode, F3: cathode) and TMNMT were conducted over a 2-week period in tinnitus patients. For tDCS, the stimulation intensity was 1.5 mA and the duration was approximately 20 min. During tDCS, patients listened to music lacking the frequency band within 1 octave of the tinnitus frequency. Patients were also instructed to listen to this music at home for at least 2 hours per day. One month after the final tDCS session, loudness (LD), awareness (AW), annoyance (AN), and effect on life (EL) of tinnitus were assessed subjectively using a visual analog scale. Results: A total of 14 patients were enrolled in this study. After treatment, a 50% or greater improvement in AN, AW, EL, and LD was observed in 57.1, 42.9, 35.7, and 28.6% of patients, respectively. Furthermore, 78.6% of patients showed a 50% or greater improvement in their tinnitus handicap inventory scores. For AN, the absence of sleep disturbance was significantly associated with treatment responsiveness (p=0.041, OR=24.0). Conclusions: Combined bifrontal tDCS and TMNMT is a promising treatment for chronic tinnitus. To maximize the treatment outcomes of this therapy, sleep disturbances should also be addressed in candidate patients.
참고문헌 (28)
- Park KH, "Prevalence and associated factors of tinnitus: data from the Korean National Health and Nutrition Examination Survey 2009-2011", J Epidemiol, 24, pp.417~426 (2014)
- Forogh B, "Repeated sessions of transcranial direct current stimulation for treatment of chronic subjective tinnitus: a pilot randomized controlled trial", Neurol Sci, 37, pp.253~259 (2016)
- Cavalcanti K, "A double-blind, placebo-controlled study of the effects of daily tDCS sessions targeting the dorsolateral prefrontal cortex on Tinnitus Handicap Inventory and Visual Analog Scale Scores", Brain Stimul, 8, pp.978~980 (2015)
- Stagg CJ, "Physiological basis of transcranial direct current stimulation", Neuroscientist, 17, pp.37~53 (2011)
- Garin P, "Short- and long-lasting tinnitus relief induced by transcranial direct current stimulation", J Neurol, 258, pp.1940~1948 (2011)
- Song JJ, "Transcranial direct current stimulation in tinnitus patients: a systemic review and meta-analysis", ScientificWorldJournal, 2012, pp.427941~ (2012)
- Kuo MF, "Therapeutic effects of non-invasive brain stimulation with direct currents (tDCS) in neuropsychiatric diseases", Neuroimage, 85(Pt 3), pp.948~960 (2014)
- Vanneste S, "Different resting state brain activity and functional connectivity in patients who respond and not respond to bifrontal tDCS for tinnitus suppression", Exp Brain Res, 210, pp.217~227 (2011)
- Okamoto H, "Listening to tailor-made notched music reduces tinnitus loudness and tinnitus-related auditory cortex activity", Proc Natl Acad Sci U S A, 107, pp.1207~1210 (2010)
- Teismann H, "Combining transcranial direct current stimulation and tailormade notched music training to decrease tinnitus-related distress--a pilot study", PLoS One, 9, pp.e89904~ (2014)
- Pal N, "Transcranial direct current stimulation for the treatment of chronic tinnitus:a randomized controlled study", Brain Stimul, 8, pp.1101~1107 (2015)
- Vanneste S, "Bilateral dorsolateral prefrontal cortex modulation for tinnitus by transcranial direct current stimulation: a preliminary clinical study", Exp Brain Res, 202, pp.779~785 (2010)
- Vanneste S, "Comparing immediate transient tinnitus suppression using tACS and tDCS: a placebo-controlled study", Exp Brain Res, 226, pp.25~31 (2013)
- Faber M, "Top down prefrontal affective modulation of tinnitus with multiple sessions of tDCS of dorsolateral prefrontal cortex", Brain Stimul, 5, pp.492~498 (2012)
- Fregni F, "Transient tinnitus suppression induced by repetitive transcranial magnetic stimulation and transcranial direct current stimulation", Eur J Neurol, 13, pp.996~1001 (2006)
- Krause B, "The effect of transcranial direct current stimulation: a role for cortical excitation", inhibition balance?, 2013, pp.7, 602~
- Mertens G, "Cochlear implantation as a long-term treatment for ipsilateral incapacitating tinnitus in subjects with unilateral hearing loss up to 10 years", Hear Res, 331, pp.1~6 (2016)
- Lee HY, "Acute-onset tinnitus is associated with contralateral hearing in sudden deafness", Audiol Neurootol, 20, pp.370~375 (2015)
- Rah YC, "Successful treatment of sudden sensorineural hearing loss assures improvement of accompanying tinnitus", Laryngoscope, 125, pp.1433~1437 (2015)
- Seydel C, "Three years later: report on the state of well-being of patients with chronic tinnitus who underwent modified tinnitus retraining therapy", Audiol Neurootol, 20, pp.26~38 (2015)
- Jalilvand H, "Hearing aid or tinnitus masker:which one is the best treatment for blast-induced tinnitus? The results of a long-term study on 974 patients", Audiol Neurootol, 20, pp.195~201 (2015)
- Folmer RL, "Tinnitus and insomnia", Am J Otolaryngol, 21, pp.287~293 (2000)
- Pan T, "Differences among patients that make their tinnitus worse or better", Am J Audiol, 24, pp.469~476 (2015)
- Møller AR, "Textbook of tinnitus" (2011), Springer
- Knight RT, "Prefrontal cortex gating of auditory transmission in humans", Brain Res, 504, pp.338~342 (1989)
- Wunderlich R, "Impact of spectral notch width on neurophysiological plasticity and clinical effectiveness of therailor-made notched music training", PLoS One, 10, pp.e0138595~ (2015)
- Strauss DJ, "Notched environmental sounds: a new hearing aid-supported tinnitus treatment evaluated in 20 patients", Clin Otolaryngol, 42, pp.172~175 (2017)
- 김봉직, "Effect of Different Sounds on the Treatment Outcome of Tinnitus Retraining Therapy", Clinical and Experimental Otorhinolaryngology, 7(2), pp.87~93 (2014), 대한이비인후과학회[DOI]