25-hydroxyvitamin D levels and body mass index in healthy postmenopausal women
2
조회
0
다운로드
6
인용
0
참고문헌
키워드
초록
Objective Obesity is associated with alterations in vitamin D (VtD) system. We evaluated the correlation between VtD level and body mass index (BMI), a standard for the evaluation of obesity in postmenopausal women. Methods To study the relationship between VtD levels and obesity, we recruited 310 healthy postmenopausal women between January 2005and March 2011 and analyzed the correlation between BMI and serum 25-hydroxyvitamin D (25-OH-VtD) level. We also analyzed the relationship between serum VtD level and bone health status such as bone mineral density measured by dual-energy X-ray absorptiometry, bone turnover marker, and parathyroid hormone (PTH). Results With a cut-off level for VtD deficiency at 30 ng/mL, 98.9% patients showed a VtD deficiency, while 87.8% patients showed a vitamin D defi ciency with a 20-ng/mL cut-off level. VtD levels had no signifi cant correlation with age, height, weight, BMI, or bone turnover markers. PTH level and serum 25-OH-VtD level showed a negative correlation. VtD level showed negative correlation with BMI, but statistically not signifi cant. Conclusion In this study, most of postmenopausal women (more than 87.8%) had a VtD defi ciency, and VtD level showed negative correlation with BMI, but was not statistically signifi cant.
Abstract
Objective Obesity is associated with alterations in vitamin D (VtD) system. We evaluated the correlation between VtD level and body mass index (BMI), a standard for the evaluation of obesity in postmenopausal women. Methods To study the relationship between VtD levels and obesity, we recruited 310 healthy postmenopausal women between January 2005and March 2011 and analyzed the correlation between BMI and serum 25-hydroxyvitamin D (25-OH-VtD) level. We also analyzed the relationship between serum VtD level and bone health status such as bone mineral density measured by dual-energy X-ray absorptiometry, bone turnover marker, and parathyroid hormone (PTH). Results With a cut-off level for VtD deficiency at 30 ng/mL, 98.9% patients showed a VtD deficiency, while 87.8% patients showed a vitamin D defi ciency with a 20-ng/mL cut-off level. VtD levels had no signifi cant correlation with age, height, weight, BMI, or bone turnover markers. PTH level and serum 25-OH-VtD level showed a negative correlation. VtD level showed negative correlation with BMI, but statistically not signifi cant. Conclusion In this study, most of postmenopausal women (more than 87.8%) had a VtD defi ciency, and VtD level showed negative correlation with BMI, but was not statistically signifi cant.
참고문헌 (18)
- Lumb GA, "The apparent vitamin D resistance of chronic renal failure: a study of the physiology of vitamin D in man", Am J Med, 50, pp.421~444 (1971)
- Rosenstreich SJ, "Deposition in and release of vitamin D3 from body fat: evidence for a storage site in the rat", J Clin Invest, 50, pp.679~687 (1971)
- Mawer EB, "The distribution and storage of vitamin D and its metabolites in human tissues", Clin Sci, 43, pp.413~431 (1972)
- Bell NH, "Evidence that 1,25-dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man", J Clin Invest, 74, pp.1540~1544 (1984)
- Liel Y, "Low circulating vitamin D in obesity", Calcif Tissue Int, 43, pp.199~201 (1988)
- Wortsman J, "Decreased bioavailability of vitamin D in obesity", Am J Clin Nutr, 72, pp.690~693 (2000)
- Saintonge S, "Implications of a new defi - nition of vitamin D deficiency in a multiracial us adolescent population: the National Health and Nutrition Examination Survey III", Pediatrics, 123, pp.797~803 (2009)
- Holick MF, "High prevalence of vitamin D inadequacy and implications for health", Mayo Clin Proc, 81, pp.353~373 (2006)
- Chapuy MC, "Prevalence of vitamin D insuffi ciency in an adult normal population", Osteoporos Int, 7, pp.439~443 (1997)
- Lips P, "A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial", J Clin Endocrinol Metab, 86, pp.1212~1221 (2001)
- Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in aults: The Evidence Report, "National Heart, Lung, and Blood Institute Obesity Education Initiative Expert Panel on the Identification, Evaluation, and Treatment of Obesity in Adults (US)", National Heart, Lung, and Blood Institute, ~ (1998)
- Holick MF, "Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease", Am J Clin Nutr, 80, pp.1678~1688 (2004)
- Heaney RP, "Functional indices of vitamin D status and ramifi - cations of vitamin D defi ciency", Am J Clin Nutr, 80, pp.1706~1709 (2004)
- Bell NH, "Evidence for alteration of the vitamin D-endocrine system in obese subjects", J Clin Invest, 76, pp.370~373 (1985)
- Andersen T, "Increased parathyroid hormone as a consequence of changed complex binding of plasma calcium in morbid obesity", Metabolism, 35, pp.147~151 (1986)
- Tsiaras WG, "Factors infl uencing vitamin D status", Acta Derm Venereol, 91, pp.115~124 (2011)
- Arunabh S, "Body fat content and 25-hydroxyvitamin D levels in healthy women", J Clin Endocrinol Metab, 88, pp.157~161 (2003)
- Scott D, "A prospective study of the associations between 25-hydroxyvitamin D, sarcopenia progression and physical activity in older adults", Clin Endocrinol, 73, pp.581~587 (2010)