본문 바로가기
KERD
논문KCI 등재

Clinical assessment of the male fertility

2

조회

0

다운로드

4

인용

0

참고문헌

키워드

주제분류산부인과학

초록

The evaluation of infertility in males consists of physical examination and semen analyses. Standardized semenanalyses depend on the descriptive analysis of sperm motility, morphology, and concentration, with a threshold levelthat must be surpassed to be considered a fertile spermatozoon. Nonetheless, these conventional parameters are notsatisfactory for clinicians since 25% of infertility cases worldwide remain unexplained. Therefore, newer tests methodshave been established to investigate sperm physiology and functions by monitoring characteristics such as motility,capacitation, the acrosome reaction, reactive oxygen species, sperm DNA damage, chromatin structure, zona pellucidabinding, and sperm-oocyte fusion. After the introduction of intracytoplasmic sperm injection technique, spermmaturity, morphology, and aneuploidy conditions have gotten more attention for investigating unexplained maleinfertility. In the present article, recent advancements in research regarding the utilization of male fertility predictiontests and their role and accuracy are reviewed.

Abstract

The evaluation of infertility in males consists of physical examination and semen analyses. Standardized semenanalyses depend on the descriptive analysis of sperm motility, morphology, and concentration, with a threshold levelthat must be surpassed to be considered a fertile spermatozoon. Nonetheless, these conventional parameters are notsatisfactory for clinicians since 25% of infertility cases worldwide remain unexplained. Therefore, newer tests methodshave been established to investigate sperm physiology and functions by monitoring characteristics such as motility,capacitation, the acrosome reaction, reactive oxygen species, sperm DNA damage, chromatin structure, zona pellucidabinding, and sperm-oocyte fusion. After the introduction of intracytoplasmic sperm injection technique, spermmaturity, morphology, and aneuploidy conditions have gotten more attention for investigating unexplained maleinfertility. In the present article, recent advancements in research regarding the utilization of male fertility predictiontests and their role and accuracy are reviewed.

참고문헌 (110)

  1. Zegers-Hochschild F, "International Committee for Monitoring Assisted Reproductive Technology (ICMART) and the World Health Organization (WHO) revised glossary of ART terminology, 2009", Fertil Steril, 92, pp.1520~1524 (2009)[DOI]
  2. Agarwal A, "A unique view on male infertility around the globe", Reprod Biol Endocrinol, 13, pp.37~ (2015)[DOI]
  3. Samplaski MK, "New generation of diagnostic tests for infertility: review of specialized semen tests", Int J Urol, 17, pp.839~847 (2010)[DOI]
  4. Rahman MS, "Sperm biology: towards understanding global issue of male infertility", Austin Androl, 1, pp.1003~ (2016)
  5. Visconti PE, "Understanding the molecular basis of sperm capacitation through kinase design", Proc Natl Acad Sci U S A, 106, pp.667~668 (2009)[DOI]
  6. Watanabe T, "The effects of dietary vitamin B12 deficiency on sperm maturation in developing and growing male rats", Congenit Anom (Kyoto), 43, pp.57~64 (2003)[DOI]
  7. Gorpinchenko I, "The influence of direct mobile phone radiation on sperm quality", Cent European J Urol, 67, pp.65~71 (2014)
  8. Bretveld R, "Influence of pesticides on male fertility", Scand J Work Environ Health, 33, pp.13~28 (2007)[DOI]
  9. Rahman MS, "Gestational exposure to bisphenol A affects the function and proteome profile of F1 spermatozoa in adult mice", Environ Health Perspect, 125, pp.238~245 (2017)
  10. Esteves SC, "Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination", Int Braz J Urol, 40, pp.443~453 (2014)
  11. Guzick DS, "Sperm morphology, motility, and concentration in fertile and infertile men", N Engl J Med, 345, pp.1388~1393 (2001)[DOI]
  12. Glazener CM, "The value of artificial insemination with husband's semen in infertility due to failure of postcoital sperm-mucus penetration--controlled trial of treatment", Br J Obstet Gynaecol, 94, pp.774~778 (1987)[DOI]
  13. Swan SH, "Semen quality in fertile US men in relation to geographical area and pesticide exposure", Int J Androl, 29, pp.62~68 (2006)[DOI]
  14. Nallella KP, "Significance of sperm characteristics in the evaluation of male infertility", Fertil Steril, 85, pp.629~634 (2006)[DOI]
  15. Haugen TB, "Semen parameters in Norwegian fertile men", J Androl, 27, pp.66~71 (2006)[DOI]
  16. Bonde JP, "Relation between semen quality and fertility: a population-based study of 430 first-pregnancy planners", Lancet, 352, pp.1172~1177 (1998)[DOI]
  17. Aitken RJ, "A prospective study of the relationship between semen quality and fertility in cases of unexplained infertility", J Androl, 5, pp.297~303 (1984)[DOI]
  18. Lewis SE, "Is sperm evaluation useful in predicting human fertility?", Reproduction, 134, pp.31~40 (2007)[DOI]
  19. Wang C, "Limitations of semen analysis as a test of male fertility and anticipated needs from newer tests", Fertil Steril, 102, pp.1502~1507 (2014)[DOI]
  20. Aitken RJ, "Relationship between the movement characteristics of human spermatozoa and their ability to penetrate cervical mucus and zona-free hamster oocytes", J Reprod Fertil, 73, pp.441~449 (1985)[DOI]
  21. Aitken RJ, "Sperm function tests and fertility", Int J Androl, 29, pp.69~75 (2006)[DOI]
  22. Mortimer ST, "CASA--practical aspects", J Androl, 21, pp.515~524 (2000)
  23. Paston MJ, "Computeraided semen analysis variables as predictors of male fertility potential", Arch Androl, 33, pp.93~99 (1994)[DOI]
  24. Hirano Y, "Relationships between sperm motility characteristics assessed by the computer-aided sperm analysis (CASA) and fertilization rates in vitro", J Assist Reprod Genet, 18, pp.213~218 (2001)
  25. Peedicayil J, "Assessment of hyperactivation, acrosome reaction and motility characteristics of spermatozoa from semen of men of proven fertility and unexplained infertility", Andrologia, 29, pp.209~218 (1997)
  26. Shibahara H, "Prediction of pregnancy by intrauterine insemination using CASA estimates and strict criteria in patients with male factor infertility", Int J Androl, 27, pp.63~68 (2004)[DOI]
  27. Davis RO, "Operational standards for CASA instruments", J Androl, 14, pp.385~394 (1993)
  28. Ho HC, "Hyperactivation of mammalian spermatozoa: function and regulation", Reproduction, 122, pp.519~526 (2001)[DOI]
  29. Sukcharoen N, "Definition of the optimal criteria for identifying hyperactivated human spermatozoa at 25 Hz using in-vitro fertilization as a functional end-point", Hum Reprod, 10, pp.2928~2937 (1995)[DOI]
  30. Kruger TF, "New method of evaluating sperm morphology with predictive value for human in vitro fertilization", Urology, 30, pp.248~251 (1987)[DOI]
  31. Moon SY, "Analysis of strict morphology of human spermatozoa", Korean J Obstet Gynecol, 41, pp.2923~2931 (1998)
  32. Cooper TG, "World Health Organization reference values for human semen characteristics", Hum Reprod Update, 16, pp.231~245 (2010)[DOI]
  33. Coetzee K, "Predictive value of normal sperm morphology: a structured literature review", Hum Reprod Update, 4, pp.73~82 (1998)[DOI]
  34. Menkveld R, "Measurement and significance of sperm morphology", Asian J Androl, 13, pp.59~68 (2011)[DOI]
  35. Van Waart J, "Predictive value of normal sperm morphology in intrauterine insemination (IUI): a structured literature review", Hum Reprod Update, 7, pp.495~500 (2001)[DOI]
  36. Check ML, "Reevaluation of the clinical importance of evaluating sperm morphology using strict criteria", Arch Androl, 48, pp.1~3 (2002)[DOI]
  37. Kiefer D, "The value of motile density, strict morphology, and the hypoosmotic swelling test in in vitro fertilization-embryo transfer", Arch Androl, 37, pp.57~60 (1996)[DOI]
  38. Menkveld R, "The evaluation of morphological characteristics of human spermatozoa according to stricter criteria", Hum Reprod, 5, pp.586~592 (1990)[DOI]
  39. Slama R, "Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities", Hum Reprod, 17, pp.503~515 (2002)[DOI]
  40. Buck Louis GM, "Semen quality and time to pregnancy: the Longitudinal Investigation of Fertility and the Environment Study", Fertil Steril, 101, pp.453~462 (2014)[DOI]
  41. Zinaman MJ, "Semen quality and human fertility: a prospective study with healthy couples", J Androl, 21, pp.145~153 (2000)
  42. Kovac JR, "Men with a complete absence of normal sperm morphology exhibit high rates of success without assisted reproduction", Asian J Androl, 19, pp.39~42 (2017)
  43. Correa JR, "The hypoosmotic swelling test: its employment as an assay to evaluate the functional integrity of the frozen-thawed bovine sperm membrane", Theriogenology, 42, pp.351~360 (1994)[DOI]
  44. Evenson DP, "Simultaneous measurement by flow cytometry of sperm cell viability and mitochondrial membrane potential related to cell motility", J Histochem Cytochem, 30, pp.279~280 (1982)[DOI]
  45. Samplaski MK, "The relationship between sperm viability and DNA fragmentation rates", Reprod Biol Endocrinol, 13, pp.42~ (2015)[DOI]
  46. Cummins JM, "A test of the human sperm acrosome reaction following ionophore challenge. Relationship to fertility and other seminal parameters", J Androl, 12, pp.98~103 (1991)
  47. Ryu BY, "Efficacy of acrosome reaction after ionophore challenge (ARIC) test in evaluation of fertilization capacity of human spermatozoa", Korean J Obstet Gynecol, 41, pp.2562~2570 (1998)
  48. Krausz C, "Two functional assays of sperm responsiveness to progesterone and their predictive values in in-vitro fertilization", Hum Reprod, 11, pp.1661~1667 (1996)[DOI]
  49. Sigman M, "Semen analysis and sperm function assays: what do they mean", Semin Reprod Med, 27, pp.115~123 (2009)[DOI]
  50. Overstreet JW, "Penetration of the zona pellucida of nonliving human oocytes by human spermatozoa in vitro", Fertil Steril, 27, pp.815~831 (1976)[DOI]
  51. Arslan M, "Predictive value of the hemizona assay for pregnancy outcome in patients undergoing controlled ovarian hyperstimulation with intrauterine insemination", Fertil Steril, 85, pp.1697~1707 (2006)[DOI]
  52. Yanagimachi R, "Immunobiology of gametes", pp.255~295 (1977), Cambridge University Press
  53. Pang MG, "Study on the clinical validity of sperm penetration assay", Korean J Fertil Steril, 20, pp.1~7 (1993)
  54. Pang MG, "Influence of sperm fertilizing capacity on embryonic development and pregnancy in in vitro fertilization", Korean J Fertil Steril, 30, pp.105~109 (2003)
  55. Chang YS, "Factors affecting penetration of zona-free hamster ova", Arch Androl, 25, pp.213~224 (1990)[DOI]
  56. Kim SH, "Efficacy of zona-free hamster ova sperm penetration assay (SPA) in evaluation of fertilization capacity of human spermatozoa", Korean J Obstet Gynecol, 41, pp.2401~2410 (1998)
  57. Aitken RJ, "Analysis of sperm function in Kartagener's syndrome", Fertil Steril, 40, pp.696~698 (1983)[DOI]
  58. Kim SH, "Establishment of normal fertile range of sperm zonafree hamster ova penetration assay in Korean male", Korean J Fertil Steril, 18, pp.63~71 (1991)
  59. Oh SA, "The sperm penetration assay predicts the litter size in pigs", Int J Androl, 33, pp.604~612 (2010)
  60. Moon SY, "Comparison of sperm morphology evaluation using strict criteria, acrosome reaction following ionophore challenge and zona-free hamster ova sperm penetration assay as prognostic factors in diagnosis of male infertility and in vitro fertilization", Korean J Fertil Steril, 29, pp.57~66 (2002)
  61. Aitken RJ, "Shedding light on chemiluminescence: the application of chemiluminescence in diagnostic andrology", J Androl, 25, pp.455~465 (2004)[DOI]
  62. Aitken RJ, "Multiple forms of redox activity in populations of human spermatozoa", Mol Hum Reprod, 9, pp.645~661 (2003)[DOI]
  63. Kobayashi H, "Quality control of reactive oxygen species measurement by luminol-dependent chemiluminescence assay", J Androl, 22, pp.568~574 (2001)
  64. Said TM, "Human sperm superoxide anion generation and correlation with semen quality in patients with male infertility", Fertil Steril, 82, pp.871~877 (2004)[DOI]
  65. Agarwal A, "Oxidation-reduction potential of semen: what is its role in the treatment of male infertility", Ther Adv Urol, 8, pp.302~318 (2016)[DOI]
  66. Cho C, "Protamine 2 deficiency leads to sperm DNA damage and embryo death in mice", Biol Reprod, 69, pp.211~217 (2003)[DOI]
  67. Lewis SE, "DNA damage to spermatozoa has impacts on fertilization and pregnancy", Cell Tissue Res, 322, pp.33~41 (2005)[DOI]
  68. Evenson DP, "Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic", Hum Reprod, 14, pp.1039~1049 (1999)[DOI]
  69. Zini A, "Potential adverse effect of sperm DNA damage on embryo quality after ICSI", Hum Reprod, 20, pp.3476~3480 (2005)[DOI]
  70. Gandini L, "Study of apoptotic DNA fragmentation in human spermatozoa", Hum Reprod, 15, pp.830~839 (2000)[DOI]
  71. Host E, "DNA strand breaks in human sperm cells: a comparison between men with normal and oligozoospermic sperm samples", Acta Obstet Gynecol Scand, 78, pp.336~339 (1999)[DOI]
  72. Saleh RA, "Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility", Fertil Steril, 79(Suppl 3), pp.1597~1605 (2003)[DOI]
  73. Bungum M, "Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome", Hum Reprod, 22, pp.174~179 (2007)[DOI]
  74. Benchaib M, "Sperm deoxyribonucleic acid fragmentation as a prognostic indicator of assisted reproductive technology outcome", Fertil Steril, 87, pp.93~100 (2007)[DOI]
  75. Evenson DP, "Relation of mammalian sperm chromatin heterogeneity to fertility", Science, 210, pp.1131~1133 (1980)[DOI]
  76. Evenson D, "Meta-analysis of sperm DNA fragmentation using the sperm chromatin structure assay", Reprod Biomed Online, 12, pp.466~472 (2006)[DOI]
  77. Collins JA, "Do sperm DNA integrity tests predict pregnancy with in vitro fertilization?", Fertil Steril, 89, pp.823~831 (2008)[DOI]
  78. Evenson DP, "Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques", J Androl, 23, pp.25~43 (2002)[DOI]
  79. Liu DY, "Evaluation and assessment of semen for IVF", ICSI, 2002, pp.4, 281~285
  80. Palermo GD, "Intracytoplasmic sperm injection (ICSI) in extreme cases of male infertility", PLoS One, 9, pp.e113671~ (2014)[DOI]
  81. Practice Committees of the American Society for Reproductive Medicine, "Intracytoplasmic sperm injection (ICSI) for non-male factor infertility: a committee opinion", Fertil Steril, 98, pp.1395~1399 (2012)[DOI]
  82. Liu DY, "Tests of human sperm function and fertilization in vitro", Fertil Steril, 58, pp.465~483 (1992)[DOI]
  83. Liu DY, "A human sperm-zona pellucida binding test using oocytes that failed to fertilize in vitro", Fertil Steril, 50, pp.782~788 (1988)[DOI]
  84. Palermo GD, "Biennial review of infertility", pp.277~289 (2011), Springer
  85. Flaherty SP, "Fertilization failures and abnormal fertilization after intracytoplasmic sperm injection", Hum Reprod, 13(Suppl 1), pp.155~164 (1998)[DOI]
  86. Mansour R, "Intracytoplasmic sperm injection: a state of the art technique", Hum Reprod Update, 4, pp.43~56 (1998)[DOI]
  87. Bartoov B, "Real-time fine morphology of motile human sperm cells is associated with IVF-ICSI outcome", J Androl, 23, pp.1~8 (2002)[DOI]
  88. Bartoov B, "Pregnancy rates are higher with intracytoplasmic morphologically selected sperm injection than with conventional intracytoplasmic injection", Fertil Steril, 80, pp.1413~1419 (2003)[DOI]
  89. Perrin A, "Intracytoplasmic morphologically selected sperm injection or intracytoplasmic sperm injection: where are we 12 years later?", Expert Rev Obstet Gynecol, 8, pp.261~270 (2013)[DOI]
  90. Setti AS, "Intracytoplasmic morphologically selected sperm injection results in improved clinical outcomes in couples with previous ICSI failures or male factor infertility: a metaanalysis", Eur J Obstet Gynecol Reprod Biol, 183, pp.96~103 (2014)[DOI]
  91. Teixeira DM, "Regular (ICSI) versus ultra-high magnification (IMSI) sperm selection for assisted reproduction", Cochrane Database Syst Rev, pp.CD010167~ (2013)
  92. Said TM, "Effects of advanced selection methods on sperm quality and ART outcome: a systematic review", Hum Reprod Update, 17, pp.719~733 (2011)[DOI]
  93. Ebner T, "A plea for a more physiological ICSI", Andrologia, 44(Suppl 1), pp.2~19 (2012)[DOI]
  94. Parmegiani L, ""Physiologic ICSI": hyaluronic acid (HA) favors selection of spermatozoa without DNA fragmentation and with normal nucleus, resulting in improvement of embryo quality", Fertil Steril, 93, pp.598~604 (2010)[DOI]
  95. Prinosilova P, "Selectivity of hyaluronic acid binding for spermatozoa with normal Tygerberg strict morphology", Reprod Biomed Online, 18, pp.177~183 (2009)[DOI]
  96. Jakab A, "Intracytoplasmic sperm injection: a novel selection method for sperm with normal frequency of chromosomal aneuploidies", Fertil Steril, 84, pp.1665~1673 (2005)[DOI]
  97. Castillo-Baso J, "Embryo quality and reproductive outcomes of spermatozoa selected by physiologic-ICSI or conventional ICSI in patients with kruger <4% and >4% normomorphology", Fertil Steril, 96, pp.S159~ (2011)
  98. Worrilow KC, "Increased clinical pregnancy rates (CPR) and statistically significant decrease in loss rates using hyaluronan in sperm selection: prospective, multi-center, double-blind, randomized clinical trial", Fertil Steril, 96, pp.S179~ (2011)
  99. World Health Organization, "WHO laboratory manual for the examination and processing of human semen", World Health Organization, ~ (2010)
  100. Lee K, "Incidence of apoptosis in parthenogenetic porcine embryos generated by using protein kinase or protein synthesis inhibitors", Anim Reprod Sci, 112, pp.261~272 (2009)[DOI]
  101. Van Den Bergh MJ, "Pronuclear zygote score following intracytoplasmic injection of hyaluronan-bound spermatozoa: a prospective randomized study", Reprod Biomed Online, 19, pp.796~801 (2009)[DOI]
  102. Menezo Y, "Physiologic (hyaluronic acid-carried) ICSI results in the same embryo quality and pregnancy rates as with the use of potentially toxic polyvinylpyrrolidone (PVP)", Fertil Steril, 94, pp.S232~ (2010)
  103. O'Flynn O'Brien KL, "The genetic causes of male factor infertility: a review", Fertil Steril, 93, pp.1~12 (2010)[DOI]
  104. Ferlin A, "Male infertility: role of genetic background", Reprod Biomed Online, 14, pp.734~745 (2007)[DOI]
  105. In't Veld P, "Sex chromosomal abnormalities and intracytoplasmic sperm injection", Lancet, 346, pp.773~ (1995)[DOI]
  106. Van Opstal D, "Determination of the parent of origin in nine cases of prenatally detected chromosome aberrations found after intracytoplasmic sperm injection", Hum Reprod, 12, pp.682~686 (1997)[DOI]
  107. Pang MG, "Numerical chromosome abnormalities are associated with sperm tail swelling patterns", Fertil Steril, 94, pp.1012~1020 (2010)[DOI]
  108. You YA, "Increased frequency of aneuploidy in long-lived spermatozoa", PLoS One, 9, pp.e114600~ (2014)[DOI]
  109. Drabovich AP, "Seminal plasma as a diagnostic fluid for male reproductive system disorders", Nat Rev Urol, 11, pp.278~288 (2014)[DOI]
  110. Kwon WS, "Discovery of predictive biomarkers for litter size in boar spermatozoa", Mol Cell Proteomics, 14, pp.1230~1240 (2015)[DOI]

관련 논문AI추천

Semen evaluation: methodological advancements in sperm quality-specific fertility assessment — A review방성규, 윤기영, 조종기, FANG XUN, Qamar Ahmad Yar, Raza Sanan, TANGA BEREKET MOLLA아세아·태평양축산학회 · Animal Bioscience2021 · 제34권 제8호Role of antioxidants in fertility preservation of sperm — A narrative review방성규, 조종기, FANG XUN, Lee Sanghoon, Naveed Muhammad Ilyas, Qamar Ahmed Yar, Raza Sanan, Roy Pantu Kumar, Saadeldin Islam M., TANGA BEREKET MOLLA아세아·태평양축산학회 · Animal Bioscience2023 · 제36권 제3호Comparison between density gradient centrifugation method, an extended version of the horizontal swim up method and the combination of both for sperm selectionAmal Kabit, Brahim Saadani, El Mehdi Hissane, Hasnae Debbarh, Ismail Kaarouch, Loic Koumba, Malak Jamil, Mohamed Ennaji, Mohamed Zarqaoui, Nourredine Louanjli, Pierre Vanderzwalmen, Rachida Cadi, Wassim Rhazi Senhaji대한산부인과학회 · Obstetrics & Gynecology Science2023 · 제66권 제3호Effect of Sperm DNA Fragmentation on Embryo Quality in Normal Responder Women in In Vitro Fertilization and Intracytoplasmic Sperm Injection김석현, 김수미, 김슬기, 지병철연세대학교의과대학 · Yonsei Medical Journal2019 · 제60권 제5호Impact of Microbial Infection on Sperm Parameters of Seminal Bacteria in Asymptomatic Subfertile MalesChang Sae Byuk, Cho Sun-Mi, Hong Young Kwon, Kim Tae Heon, Kim Tae Jin, Lee Dong Hyeon, Lee Seung-Ryeol, Park Dong Soo, Yu Young Dong대한요로생식기감염학회 · Urogenital Tract Infection2023 · 제18권 제3호A Simple Confocal Microscopy-based Method for Assessing Sperm Movement김민수, 김성우, 김찬란, 전익수, 황인설한국발생생물학회 · 발생과 생식2017 · 제21권 제3호

이 간행물의 다른 논문 (8건)