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척수손상 모델 흰쥐에서의 기능적 자기자극 치료의 효과

Effects of Functional Magnetic Stimulation on the Functional Recovery in a Rat Model of Spinal Cord Injury

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초록

Objective: To investigate the effects of functional magnetic stimulation (FMS) on the functional recovery in a rat model of spinal cord injury (SCI).Method: Forty-five Sprague-Dawley rats (200∼250 grams, female) were used. Rats were laminectomized and the T9 segment of spinal cord was contused using New York University (NYU) spinal impactor. Ten gram weight rod was dropped from a height of 25 mm to produce moderately contused spinal cord injury model. The animals were randomly assigned to 2 groups: one exposed to FMS (FMS group) and the other not exposed to FMS (non-FMS group). Transcranial functional magnetic stimulation was noninvasively applied for 4 weeks. To compare the results between FMS group and non-FMS group, motor functions were evaluated with the Basso, Beattie, and Bresnahan (BBB) locomtor rating scale and inclined plane test, and somatosensory evoked potentials (SEP) and motor evoked potentials (MEP) were also recorded. Results: There was a significant difference in locomotor recovery between FMS group and non-FMS group (p<0.05). Measurement of MEP was also indicated that amplitude of MEP in FMS group is larger than that in non-FMS group. Conclusion: These results indicate that FMS may have beneficial effects on motor recovery after spinal cord injury and the benefits of FMS could be an additional non-invasive therapeutic method for clinical trials in patients with spinal cord injury.

Abstract

Objective: To investigate the effects of functional magnetic stimulation (FMS) on the functional recovery in a rat model of spinal cord injury (SCI).Method: Forty-five Sprague-Dawley rats (200∼250 grams, female) were used. Rats were laminectomized and the T9 segment of spinal cord was contused using New York University (NYU) spinal impactor. Ten gram weight rod was dropped from a height of 25 mm to produce moderately contused spinal cord injury model. The animals were randomly assigned to 2 groups: one exposed to FMS (FMS group) and the other not exposed to FMS (non-FMS group). Transcranial functional magnetic stimulation was noninvasively applied for 4 weeks. To compare the results between FMS group and non-FMS group, motor functions were evaluated with the Basso, Beattie, and Bresnahan (BBB) locomtor rating scale and inclined plane test, and somatosensory evoked potentials (SEP) and motor evoked potentials (MEP) were also recorded. Results: There was a significant difference in locomotor recovery between FMS group and non-FMS group (p<0.05). Measurement of MEP was also indicated that amplitude of MEP in FMS group is larger than that in non-FMS group. Conclusion: These results indicate that FMS may have beneficial effects on motor recovery after spinal cord injury and the benefits of FMS could be an additional non-invasive therapeutic method for clinical trials in patients with spinal cord injury.

참고문헌 (36)

  1. Lim PA, "Recovery and regeneration after spinal cord injury: a review and summary of recent literature", Ann Acad Med Singapore, 36, pp.49~57 (2007)
  2. Lin VW, "Spinal cord medicine, principle and practice", pp.749~763 (2003), Demos
  3. Yamanishi T, "Effect of functional continuous magnetic stimulation on urethral closure in healthy volunteers", Urology, 54, pp.652~655 (1999)
  4. Fitzgerald PB, "Motor cortical excitability and clinical response to rTMS in depression", J Affect Disord, 82, pp.71~76 (2004)
  5. Lefaucheur JP, "Interventional neurophysiology for pain control: duration of pain relief following repetitive transcranial magnetic stimulation of the motor cortex", Neurophysiol Clin, 31, pp.247~252 (2001)
  6. Lefaucheur JP, "Stroke recovery can be enhanced by using repetitive transcranial magnetic stimulation (rTMS)", Neurophysiol Clin, 36, pp.105~115 (2006)
  7. Maeda F, "Interindividual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability", Exp Brain Res, 133, pp.425~430 (2000)
  8. Málly J, "New advances in the rehabilitation of CNS diseases applying rTMS", Expert Rev Neurother, 7, pp.165~177 (2007)
  9. Martin PI, "Transcranial magnetic stimulation as a complementary treatment for aphasia", Semin Speech Lang, 25, pp.181~191 (2004)
  10. Takeuchi N, "Repetitive transcranial magnetic stimulation of contralesional primary motor cortex improves hand function after stroke", Stroke, 36, pp.2681~2686 (2005)
  11. Wu AD, "Functional neuroimaging and repetitive transcranial magnetic stimulation in Parkinson's disease", Rev Neurol Dis, 4, pp.1~9 (2007)
  12. Longo FM, "Electromagnetic fields influence NGF activity and levels following sciatic nerve transection", J Neurosci Res, 55, pp.230~237 (1999)
  13. Macias MY, "Directed and enhanced neurite growth with pulsed magnetic field stimulation", Bioelectromagnetics, 21, pp.272~286 (2000)
  14. Post A, "Repetitive transcranial magnetic stimulation in rats: evidence for a neuroprotective effect in vitro and in vivo", Eur J Neurosci, 11, pp.3247~3254 (1999)
  15. Sisken BF, "Stimulation of rat sciatic nerve regeneration with pulsed electromagnetic fields", Brain Res, 485, pp.309~316 (1989)
  16. Walker JL, "Enhancement of functional recovery following a crush lesion to the rat sciatic nerve by exposure to pulsed electromagnetic fields", Exp Neurol, 125, pp.302~305 (1994)
  17. Young W, "Spinal cord contusion models", Prog Brain Res, 137, pp.231~255 (2002)
  18. Basso DM, "Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection", Exp Neurol, 139, pp.244~256 (1996)
  19. Rivlin AS, "Objective clinical assessment of motor function after experimental spinal cord injury in the rat", J Neurosurg, 47, pp.577~581 (1977)
  20. Bassett CA, "Beneficial effects of electromagnetic fields", J Cell Biochem, 51, pp.387~393 (1993)
  21. Shimada Y, "Effects of therapeutic magnetic stimulation on acute muscle atrophy in rats after hindlimb suspension", Biomed Res, 27, pp.23~27 (2006)
  22. Vallbona C, "Evolution of magnetic therapy from alternative to traditional medicine", Phys Med Rehabil Clin N Am, 10, pp.729~754 (1999)
  23. Kanje M, "Pretreatment of rats with pulsed electromagnetic fields enhances regeneration of the sciatic nerve", Bioelectromagnetics, 14, pp.353~359 (1993)
  24. Orgel MG, "Pulsing electromagnetic field therapy in nerve regeneration: an experimental study in the cat", Plast Reconstr Surg, 73, pp.173~183 (1984)
  25. Raji AR, "Effects of high-peak pulsed electromagnetic field on the degeneration and regeneration of the common peroneal nerve in rats", J Bone Joint Surg Br, 65, pp.478~492 (1983)
  26. Greenebaum B, "Effects of pulsed magnetic fields on neurite outgrowth from chick embryo dorsal root ganglia", Bioelectromagnetics, 17, pp.293~302 (1996)
  27. Crowe MJ, "Expose to Pulsed Magnetic Fields Enhances Motor recovery in cats after spinal cord Injury", Spine, 28, pp.2660~2666 (2003)
  28. Poirrier AL, "Repetitive transcranical magnetic stimulation improves open field locomotor recovery after low but not high thoracic spinal cord compression-injury in adult rats", J Neurosci Res, 75, pp.253~261 (2004)
  29. Belci M, "Magnetic brain stimulation can improve clinical outcome in incomplete spinal cord injured patients", Spinal Cord, 42, pp.417~419 (2004)
  30. Okano H, "Regeneration-based therapies for spinal cord injuries", Neurochem Int, 51, pp.68~73 (2007)
  31. Valero-Cabré A, "Modulation of spinal cord excitability by subthreshold repetitive transcranial magnetic stimulation of the primary motor cortex in humans", Neuroreport, 12, pp.3845~3848 (2001)
  32. Pridmore S, "Transcranial magnetic stimulation applications and potential use in chronic pain: studies in waiting", J Neurol Sci, 182, pp.1~4 (2000)
  33. Romero JR, "Subthreshold low frequency repetitive transcranial magnetic stimulation selectively decreases facilitation in the motor cortex", Clin Neurophysiol, 113, pp.101~107 (2002)
  34. Fehlings MG, "The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury", Exp Neurol, 132, pp.220~228 (1995)
  35. Gruner JA, "Myoelectric evoked potentials versus locomotor recovery in chronic spinal cord injured rats", J Neurotrauma, 10, pp.327~347 (1993)
  36. Nashmi R, "Serial recording of somatosensory and myoelectric motor evoked potentials: role in assessing functional recovery after graded spinal cord injury in the rat", J Neurotrauma, 14, pp.151~159 (1997)

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