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Analgesic Effects of Transcranial Direct Current Stimulation on Central Neuropathic Pain in Spinal Cord Contusive Rat Model

최완석|김기도|김경윤|심기철|Hyun-Seung Kim
한국콘텐츠학회 (The Korea Contents Association)|2012.03|International Journal of Contents|제8권 제1호|pp. 74-81

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참고문헌

키워드

tDCSContusive Spinal Cord InjuryCentral Neuropathic PainAnagesic Effectc-fos.
주제분류컴퓨터학

초록

The aim is to investigate the analgesic effect of transcranial direct current stimulation(tDCS) on central neuropathic pain(CNP) in spinal cord contusive rat model. Twenty Sprague-Dawley rats($250{\pm}50$ g, male) were used. Thoracic spinal cord(T10) was contused using New York University(NYU) spinal cord impactor. The animals were randomly assigned to two groups; GroupI: Non-treatment after SCI induction(n=10), GroupII: application of tDCS(0.1 mA, 20 min/time, 2 times/day, 5 days/6week) after SCI induction(n=10). Assess the effect of tDCS using the Basso Beattie Bresnahan(BBB) locomotor rating scales, Touch $test^{TM}$ sensory evaluator(TTSE), Plantar test$^{\circledR}$after contusion at the $2^{nd}$, 3rd, $4^{th}$, $5^{th}$, $6^{th}$ week and the immunohistochemistric response of c-fos in the thalamus, cerebral cortex after contusion at the 3rd, $6^{th}$ week after SCI. The scores of BBB scales were significantly different from 3rdweek. TTSE were different significantly over time, but there were no differences at each evaluation times on between-measure time effects. Plantar test were different significantly over time and there were difference at the $4^{th}$, $6^{th}$ week after SCI on between-measure time effects. Also, immunohistochemistric response of c-fos was reduced significantly from 3rd, $6^{th}$ week after SCI in tDCS group compared with control group in thalamus and cortex. These results identified that tDCS of non-invasive therapeutic method may have beneficial analgesic effect on CNP after SCI with behavioral test and immunohistochemical test.

Abstract

The aim is to investigate the analgesic effect of transcranial direct current stimulation(tDCS) on central neuropathic pain(CNP) in spinal cord contusive rat model. Twenty Sprague-Dawley rats($250{\pm}50$ g, male) were used. Thoracic spinal cord(T10) was contused using New York University(NYU) spinal cord impactor. The animals were randomly assigned to two groups; GroupI: Non-treatment after SCI induction(n=10), GroupII: application of tDCS(0.1 mA, 20 min/time, 2 times/day, 5 days/6week) after SCI induction(n=10). Assess the effect of tDCS using the Basso Beattie Bresnahan(BBB) locomotor rating scales, Touch $test^{TM}$ sensory evaluator(TTSE), Plantar test$^{\circledR}$after contusion at the $2^{nd}$, 3rd, $4^{th}$, $5^{th}$, $6^{th}$ week and the immunohistochemistric response of c-fos in the thalamus, cerebral cortex after contusion at the 3rd, $6^{th}$ week after SCI. The scores of BBB scales were significantly different from 3rdweek. TTSE were different significantly over time, but there were no differences at each evaluation times on between-measure time effects. Plantar test were different significantly over time and there were difference at the $4^{th}$, $6^{th}$ week after SCI on between-measure time effects. Also, immunohistochemistric response of c-fos was reduced significantly from 3rd, $6^{th}$ week after SCI in tDCS group compared with control group in thalamus and cortex. These results identified that tDCS of non-invasive therapeutic method may have beneficial analgesic effect on CNP after SCI with behavioral test and immunohistochemical test.

참고문헌 (48)

  1. G. Davidoff, "Function-Limiting DysestheticPainSyndrome AmongTraumaticSpinal Cord Injury Patients: ACross- Sectional Study", Pain, 29(1), pp.39~48 (1987)
  2. S. B. McMahon, "Mechanism of Sympathetic Pain", Br Med Bull, 47(3), pp.584~600 (1991)
  3. J. Sato, "Adrenergic Excitation of Cutaneous Pain Receptors Induced by Peripheral Nerve Injury", Science, 251(5001), pp.1608~1610 (1991)
  4. Z. Seltzer, "Sympathetically-Maintained CausalgiformDisorders in a Model for Neuropathic Pain: AReview", J Basic ClinPhysiolPharmacol, 2(1), pp.17~61 (1991)
  5. Y. S. Gwak, "The Mechanism of Central Pain Induced by Spinal Cord Injury", 박사, pp.2001
  6. V. Chapman, "A Novel Spinal Action of Mexiletine in Spinal Somatosensory Transmission of Nerve Injured Rats", Pain, 77(3), pp.289~296 (1998)
  7. P. Siddall, "AllodyniaFollowingTraumatic Spinal Cord Injury in the Rat", Neuroreport, 6(9), pp.1241~1244 (1995)
  8. R. P. Yezierski, "Pain Following Spinal Cord Injury: Pathophysiology and Central Mechanisms", Prog Brain Res, 129, pp.429~449 (2000)
  9. T. N. Bryce, "Pain AfterSpinal Cord Injury", Phys Med RehabilClin N Am, 11(1), pp.157~168 (2000)
  10. 배영경, "척수손상 흰쥐의 통증에 대한 지속적인 반복 경두개 자기자극의 효과", Annals of Rehabilitation Medicine, 34(3), pp.259~264 (2010), 대한재활의학회
  11. D. Liebetanz, "Pharmacological Approach to the Mechanisms of Transcranial DC-Stimulation-Induced After-Effects of Human Motor Cortex Excitability", Brain, 125(10), pp.2238~2247 (2002)
  12. M. A. Nitsche, "Excitability Changes Induced in the Human Motor Cortex by Weak TranscranialDirectCurrent Stimulation", J Physiol, 527(3), pp.633~639 (2000)
  13. M.A. Nitsche, "Facilitation of Implicit Motor Learning by Weak TranscranialDirectCurrent Stimulation of the Primary Motor Cortex in the Human", J CognNeurosci, 15(4), pp.619~626 (2003)
  14. M. A. Nitsche, "Pharmacological Modulation of Cortical Excitability Shifts Induced by TranscranialDirectCurrent Stimulation in Humans", J Physiol, 553(1), pp.293~301 (2003)
  15. A. Antal, "Towards UnravellingTask-Related Modulations of NeuroplasticChangesInduced in the Human Motor Cortex", Eur J Neurosci, 26(9), pp.2687~2691 (2007)
  16. B. R. Webster, "Noninvasive Brain Stimulation in Stroke Rehabilitation", NeuroRx, 3(4), pp.474~481 (2006)
  17. P. S. Boggio, "Transcranial DC Stimulation Coupled with TENS for the Treatment of Chronic Pain: APreliminaryStudy", Clin J Pain, 25(8), pp.691~695 (2009)
  18. F. Fregni, "A Sham-Controlled, Phase ⅡTrial of TranscranialDirectCurrent Stimulation for the Treatment of Central Pain in Traumatic Spinal Cord Injury", Pain, 122(1), pp.197~209 (2006)
  19. C. Abbadie, "c-fosExpression in Rat Lumbar Spinal Cord During the Development of Adjuvant-Induced Arthritis", Neuroscience, 48(4), pp.985~993 (1992)
  20. C. B. Hathaway, "Distribution of Fos-Like Immunoreactivity in the Caudal Brainstem of the Rat Following Noxious Chemical Stimulation of the TempomandibularJoint", J Comp Neurol, 356(3), pp.444~456 (1995)
  21. J. A. Harris, "Using c-fos as a Neural Marker of Pain", Brain Res Bull, 45(1), pp.1~8 (1998)
  22. S. J. Kim, "Mechanism of Motor Recovery Induced by Repeated Transcranial Direct Current Stimulation in Stroke Rat Model", 박사, pp.2001
  23. D. M. Basso, "Graded Histological and LocomotorOutcomes after Spinal Cord Contusion Using the NYU Weight-Drop Device Versus Transection", Exp Neurol, 139(2), pp.224~256 (1996)
  24. S. H. Kim, "An Experimental Model for Peripheral Neuropathy Produced by Segmental Spinal Nerve Ligation in the Rat", Pain, 50(3), pp.355~363 (1992)
  25. S. R. Chaplan, "Efficacy of Spinal NMDA Receptor Antagonism in Formalin Hyperalgesia and Nerve Injury Evoked Allodynia in the Rat", J Pharmacol Exp Ther, 280(2), pp.829~838 (1997)
  26. G. Paxinos, "TheRat Brain in Stereotaxic Coordinates", pp.13~38 (2005), Academic Press Inc.
  27. B. D. Nicholson, "Evaluation and Treatment of Central Pain Syndromes", 62(5), pp.S30~S36 (2004)
  28. B. A. Wallace, "Deep Brain Stimulation for the Treatment of Chronic, Intractable Pain", Neurosurg Clin N Am, 15(3), pp.343~357 (2004)
  29. A. Antal, "Direct Current Stimulation Over v5 Enhances VisuomotorCoordination by Improving Motion Perception in Humans", J CognNeurosci, 16(4), pp.521~527 (2004)
  30. S. Hesse, "Combined TranscranialDirectCurrent Stimulation and Robot- Assisted Arm Training in SubacuteStrokePatients: APilotStudy", Restor Neurol Neurosci, 25(1), pp.9~15 (2007)
  31. A. Monti, "Improved Naming after TranscranialDirectCurrent Stimulation in Aphasia", J Neurol Neurosurg Psychiatry, 79(4), pp.451~453 (2008)
  32. A. Antal, "TranscranialDirectCurrent Stimulation Over Somatosensory Cortex Decreases Experimentally Induced Acute Pain Perception", Clin J Pain, 24(1), pp.56~63 (2008)
  33. P. S. Boggio, "Modulatory Effects of Anodal TranscranialDirectCurrent Stimulation on Perception and Pain Thresholds in Healthy Volunteers", Eur J Neurol, 15(10), pp.1124~1130 (2008)
  34. F. Fregni, "Randomized, Sham-Controlled, Proof of Principle Study of TranscranialDirectCurrent Stimulation for the Treatment of Pain in Fibromyalgia", Arthritis Rheum, 54(12), pp.3988~3998 (2006)
  35. C. E. Hulsebosch, "Rodent Model of Chronic Central Pain after Spinal Cord Contusion Injury and Effects of Gabapentin", J Neurotrauma, 17(12), pp.1205~1217 (2000)
  36. C. D. Mills, "Changes in Exploratory Behavior as a Measure of Chronic Central Pain Following Spinal Cord Injury", J Neurotrauma, 18(10), pp.1091~1105 (2001)
  37. D. Wachter, "TranscranialDirectCurrent Stimulation Induces Polarity-Specific Changes of Cortical Blood Perfusion in the Rat", Exp Neurol, 227(2), pp.322~327 (2011)
  38. T. Kamida, "TranscranialDirectCurrent Stimulation Decreases Convulsions and Spatial Memory Deficits Following Pilocarpine-Induced Status Epilepticus in Immature Rats", Behav Brain Res, 217(1), pp.99~103 (2011)
  39. Y. S. Gwak, "Attenuation of Mechanical HyperalgesiaFollowingSpinal Cord Injury by Administration of Antibodies to Nerve Growth Factor in the Rat", Neurosci Lett, 336(2), pp.117~120 (2003)
  40. B. C. Hains, "Changes in Serotonin, Serotonin Transporter Expression and Serotonin Denervation Supersensitivity: Involvement in Chronic Central Pain after Spinal Hemisection in the Rat", Exp Neurol, 175(2), pp.347~362 (2002)
  41. I. Omana-Zapata, "QX-314 Inhibits Ectopic Nerve Activity Associated with Neuropathic Pain", Brain Res, 771(2), pp.228~237 (1997)
  42. M. D. Christensen, "Mechanical and Thermal Allodynia in Chronic Central Pain Following Spinal Cord Injury", Pain, 68(1), pp.97~107 (1996)
  43. R. Rolke, "Quantitative Sensory Testing: AComprehensiveProtocol for Clinical Trials", EurJ Pain, 10(1), pp.77~88 (2006)
  44. C. G. Bachmann, "Thermal Hypoesthesia Differentiates Secondary Restless Legs Syndrome Associated with Small FiberNeuropathy from Primary Restless Legs Syndrome", Brain, 133(3), pp.762~770 (2010)
  45. E. Bullitt, "Expression of c-fos-Like Protein as a Marker for Neuronal Activity Following Noxious Stimulation in the Rat", J Comp Neurol, 296(4), pp.517~530 (1990)
  46. A. M. Strassman, "Somatotopic and Laminar Organization of fos-Like Immunoreactivity in the Medullary and Upper Cervical Dorsal Horn Induced by Noxious Facial Stimulation in the Rat", J Comp Neurol, 331(4), pp.495~516 (1993)
  47. M. A. Nitsche, "ModulatingParameters of Excitability During and after TranscranialDirectCurrent Stimulation of the Human Motor Cortex", J Physiol, 568(1), pp.291~303 (2005)
  48. T. Tsubokawa, "Treatment of Thalamic Pain by Chronic Motor Cortex Stimulation", Pacing ClinElectrophysiol, 14(1), pp.131~134 (1991)

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