뇌졸중 쥐모델에서 비침습적뇌자극치료 이후신경생리학적 검사에서 나타난 뇌가소성과 연관된 변화
Plasticity Associated Changes in Neurophysiological Tests Following Non Invasive Brain Stimulation in Stroke Rat Model
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Neuromodulation therapy has been used to an adjunctive treatment promoting motor recovery in strokepatients. The objective of the study was to determine the effect of repetitive transcranial magnetic stimulation (rTMS)on neurobehavioral recovery and evoked potentials in rats with middle cerebral artery occlusion. Methods: SeventySprague-Daley rats were induced permanent middle cerebral artery occlusion (MCAO) stroke model and successfulstroke rats (n=56) assigned to the rTMS (n=28) and sham (n=28) group. The 10 Hz, high frequency rTMS gave onipsilesional forepaw motor cortex during 2 weeks in rTMS group. The somatosensory evoked potential (SSEP) and motorevoked potential (MEP) were used to evaluate the electrophysiological changes. Behavioral function of the strokerat was evaluated by the Rota rod and Garcia test. Results: Forty rats (NrTMS=20; Nsham=20) completed all experimentalcourse. The rTMS group showed better performance than sham group in Rota rod test and Garcia test at day 11(p<0.05) but not day 18 (p>0.05). The amplitude of MEP and SSEP in rTMS group was larger than sham group atday 18 (p<0.05). Conclusions: These data confirm that the high frequency rTMS on ipsilesional cerebral motor cortexcan help the early recovery of motor performance in permanent middle cerebral artery stroke model and it may simultaneouslyassociate with changes in neurophysiological activity in brain.(Korean J Clin Neurophysiol 2014;16:62-69)
Abstract
Background: Neuromodulation therapy has been used to an adjunctive treatment promoting motor recovery in strokepatients. The objective of the study was to determine the effect of repetitive transcranial magnetic stimulation (rTMS)on neurobehavioral recovery and evoked potentials in rats with middle cerebral artery occlusion. Methods: SeventySprague-Daley rats were induced permanent middle cerebral artery occlusion (MCAO) stroke model and successfulstroke rats (n=56) assigned to the rTMS (n=28) and sham (n=28) group. The 10 Hz, high frequency rTMS gave onipsilesional forepaw motor cortex during 2 weeks in rTMS group. The somatosensory evoked potential (SSEP) and motorevoked potential (MEP) were used to evaluate the electrophysiological changes. Behavioral function of the strokerat was evaluated by the Rota rod and Garcia test. Results: Forty rats (NrTMS=20; Nsham=20) completed all experimentalcourse. The rTMS group showed better performance than sham group in Rota rod test and Garcia test at day 11(p<0.05) but not day 18 (p>0.05). The amplitude of MEP and SSEP in rTMS group was larger than sham group atday 18 (p<0.05). Conclusions: These data confirm that the high frequency rTMS on ipsilesional cerebral motor cortexcan help the early recovery of motor performance in permanent middle cerebral artery stroke model and it may simultaneouslyassociate with changes in neurophysiological activity in brain.(Korean J Clin Neurophysiol 2014;16:62-69)
참고문헌 (28)
- Walsh V, "Manipulating brains", Behav Neurol, 17, pp.131~134 (2006)
- Alonso-Alonso M, "Brain stimulation in poststroke rehabilitation", Cerebrovasc Dis, 24, pp.157~166 (2007)
- Harvey RL, "Cortical brain stimulation: a potential therapeutic agent for upper limb motor recovery following stroke", TopStroke Rehabil, 14, pp.54~67 (2007)
- Minhas AS, "Magnetic flux density measurement with balanced steady state free precession pulse sequence for MREIT: a simulation study", Conf Proc IEEE Eng Med Biol Soc, 2009, pp.2276~2278 (2009)
- Barker AT, "Non-invasive magnetic stimulation of human motor cortex", Lancet, 1, pp.1106~1107 (1985)
- Kobayashi M, "Transcranial magnetic stimulation in neurology", Lancet Neurol, 2, pp.145~156 (2003)
- Sokhadze EM, "rTMS neuromodulation improves electrocortical functional measures of information processing and behavioral responses in autism", Front Syst Neurosci, 8, pp.134~ (2014)
- Maeda F, "Interindividual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability", Exp Brain Res, 133, pp.425~430 (2000)
- Martin PI, "Transcranial magnetic stimulation as a complementary treatment for aphasia", Semin Speech Lang, 25, pp.181~191 (2004)
- Kim YH, "Repetitive transcranial magnetic stimulation-induced corticomotor excitability and associated motor skill acquisition in chronic stroke", Stroke, 37, pp.1471~1476 (2006)
- Yue L, "The effects of chronic repetitive transcranial magnetic stimulation on glutamate and gamma-aminobutyric acid in rat brain", Brain Res, 1260, pp.94~99 (2009)
- Muller MB, "Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain", Neuropsychopharmacology, 23, pp.205~215 (2000)
- Kole MH, "Changes in 5-HT1A and NMDA binding sites by a single rapid transcranial magnetic stimulation procedure in rats", Brain Res, 826, pp.309~312 (1999)
- Antonsson B, "Bax and other pro-apoptotic Bcl-2 family “killer-proteins” and their victim the mitochondrion", Cell Tissue Res, 306, pp.347~361 (2001)
- Fujiki M, "Repetitive transcranial magnetic stimulation for protection against delayed neuronal death induced by transient ischemia", J Neurosurg, 99, pp.1063~1069 (2003)
- Longa EZ, "Reversible middle cerebral artery occlusion without craniectomy in rats", Stroke, 20, pp.84~91 (1989)
- Lee SU, "Mild to moderate early exercise promotes recovery from cerebral ischemia in rats", Can J Neurol Sci, 36, pp.443~449 (2009)
- Chen J, "Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats", Stroke, 32, pp.1005~1011 (2001)
- Hamm RJ, "The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury", J Neurotrauma, 11, pp.187~196 (1994)
- Garcia JH, "Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation", Stroke, 26, pp.627~634 (1995)
- Bazley FA, "Plasticity associated changes in cortical somatosensory evoked potentials following spinal cord injury in rats", Conf Proc IEEE Eng Med Biol Soc, pp.2005~2008 (2011)
- Agrawal G, "Evoked potential versus behavior to detect minor insult to the spinal cord in a rat model", J Clin Neurosci, 16, pp.1052~1055 (2009)
- Agrawal G, "Characterization of graded multicenter animal spinal cord injury study contusion spinal cord injury using somatosensory-evoked potentials", Spine, 35, pp.1122~1127 (2010)
- All AH, "Evoked potential and behavioral outcomes for experimental autoimmune encephalomyelitis in Lewis rats", Neurol Sci, 31, pp.595~601 (2010)
- Rotenberg A, "Lateralization of forelimb motor evoked potentials by transcranial magnetic stimulation in rats", Clin Neurophysiol, 121, pp.104~108 (2010)
- Yoon KJ, "Mechanism of functional recovery after repetitive transcranial magnetic stimulation (rTMS) in the subacute cerebral ischemic rat model: neural plasticity or anti-apoptosis?", Exp Brain Res, 214, pp.549~556 (2011)
- 김상준, "Functional and Histologic Changes After Repeated Transcranial Direct Current Stimulation in Rat Stroke Model", Journal of Korean Medical Science, 25(10), pp.1499~1505 (2010), 대한의학회
- Nitsche MA, "Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans", Neurology, 57, pp.1899~1901 (2001)