뇌졸중 환자에서 뇌졸중 후 우울증상의 중증도와 인지기능의 상관관계
Relationship between the Severity of Poststroke Depression (PSD) and Cognitive Function in the Patients with Stroke
2
조회
0
다운로드
5
인용
0
참고문헌
키워드
초록
Objective: To investigate the correlation between poststroke depression (PSD) and the cognitive impairment in the patients with subacute stroke. Method: The subjects were 53 patients with cerebral infarction (n=28) and cerebral hemorrhage (n=25). These patients had a mean age of 64.3. The mean onset time was 2.7 months. The location of stroke was in the right hemisphere in 24 subjects, left hemisphere in 23, and bilateral in 6. The severity of PSD was evaluated by Beck Depression Inventory (BDI), Korean Geriatric Depression Scale (KGDS), and Hamilton Rating Scale for Depression (HRS-D) and the evaluation of cognitive impairments was based on Computerized Neuro-psychological Test (CNT), Mini-Mental State Examination (MMSE). The Pearson correlation was used as a measure of the strength of association between cognitive impairments and PSD. Independent t-tests were calculated to compare differences in cognitive functioning according to hemispheric involvement. Results: PSD was diagnosed in 33 of 53 patients by the BDI, in 28 of 43 patients by the KGDS and in 22 of 45 patients by the HRS-D. Scores in the verbal and visual learning domains of the CNT were significantly correlated with scores on the BDI, KGDS, and HRS-D, but scores on the MMSE were unrelated to any of these measures of depression. Conclusion: We suggest the use of the CNT in poststroke depression patients could be a useful tool from the viewpoint of differentiation of PSD patients with or without cognitive impairment and the diagnosis for poststroke depression should be conducted by self rating and objective assessments.
Abstract
Objective: To investigate the correlation between poststroke depression (PSD) and the cognitive impairment in the patients with subacute stroke. Method: The subjects were 53 patients with cerebral infarction (n=28) and cerebral hemorrhage (n=25). These patients had a mean age of 64.3. The mean onset time was 2.7 months. The location of stroke was in the right hemisphere in 24 subjects, left hemisphere in 23, and bilateral in 6. The severity of PSD was evaluated by Beck Depression Inventory (BDI), Korean Geriatric Depression Scale (KGDS), and Hamilton Rating Scale for Depression (HRS-D) and the evaluation of cognitive impairments was based on Computerized Neuro-psychological Test (CNT), Mini-Mental State Examination (MMSE). The Pearson correlation was used as a measure of the strength of association between cognitive impairments and PSD. Independent t-tests were calculated to compare differences in cognitive functioning according to hemispheric involvement. Results: PSD was diagnosed in 33 of 53 patients by the BDI, in 28 of 43 patients by the KGDS and in 22 of 45 patients by the HRS-D. Scores in the verbal and visual learning domains of the CNT were significantly correlated with scores on the BDI, KGDS, and HRS-D, but scores on the MMSE were unrelated to any of these measures of depression. Conclusion: We suggest the use of the CNT in poststroke depression patients could be a useful tool from the viewpoint of differentiation of PSD patients with or without cognitive impairment and the diagnosis for poststroke depression should be conducted by self rating and objective assessments.
참고문헌 (19)
- Gordon WA, "Poststroke depression: an examination of the literature", Arch Phys Med Rehabil, 78, pp.658~663 (1997)
- Shimoda K, "The relationship between poststroke depression and lesion location in long-term follow-up", Biol Psychiatry, 45, pp.187~192 (1999)
- Robinson RG, "Poststroke depression: prevalence, diagnosis, treatment, and disease progression", Biol Psychiatry, 54, pp.376~387 (2003)
- MacHale SM, "Depression and its relation to lesion location after stroke", J Neurol Neurosurg Psychiatry, 64, pp.371~374 (1998)
- Tateno A, "Phenomenological characteristics of poststroke depression: early-versus late- onset", Am J Geriatr Psychiatry, 10, pp.575~582 (2002)
- Whyte EM, "Post stroke depression: epidemiology, pathophysiology, and biological treatment", Biol Psychiatry, 52, pp.253~264 (2002)
- Lee MK, "A Standardization Study of Beck Depression Inventory (I): Korean Version (K-BDI): reliability land Factor Analysis", J Korean Psychopath, 4, pp.77~95 (1995)
- Berg A, "Poststroke depression in acute phase after stroke", Cerebrovasc Dis, 12, pp.14~20 (2001)
- Jung IK, "A preliminary study on standardization of Korean form of geriatric depression scale (KGDS)", J Korean Neuropsychiatr, 37, pp.340~351 (1998)
- Gillen R, "Depressive symptoms and history of depression predict rehabilitation efficiency in stroke patients", Arch Phys Med Rehabil, 82, pp.1645~1649 (2001)
- Paolucci S, "Poststroke depression and its role in rehabilitation of inpatients", Arch Phys Med Rehabil, 80, pp.985~990 (1999)
- Robinson RG, "Mood disorder in stroke patients: importance of location of lesion", Brain, 107, pp.81~93 (1984)
- Gainotti G, "Relation between depression after stroke, antidepressant therapy, and functional recovery", J Neurol Neurosurg Psychiatry, 71, pp.258~261 (2001)
- Angelelli P, "Development of neuropsychiatric symptoms in poststroke patients: a cross-sectional study", Acta Psychiatr Scand, 110, pp.55~63 (2004)
- Morris PL, "Prevalence and course of depressive disorders in hospitalized stroke patients", Int J of Psychiatry Med, 20, pp.349~364 (1990)
- Schramke CJ, "Poststroke depression and anxiety: different assessment methods result in variations in incidence and severity estimates", J Clin Exp Neuropsychol, 20, pp.723~737 (1998)
- Nys GM, "Early depressive symptoms after stroke: neuropsychological correlates and lesion characteristics", J Neurol Sci, 228, pp.27~33 (2005)
- Kase CS, "Intellectual decline after stroke: the Framingham study", Stroke, 29, pp.805~812 (1998)
- Kauhanen M, "Poststroke depression correlates with cognitive impairment and neurological deficits", Stroke, 30, pp.1875~1880 (1999)