Evaluation of the prevalence and clinical impact of toxocariasis in patients with eosinophilia of unknown origin
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Background/Aims: Eosinophilia has numerous diverse causes, and in many patients, it is not possible to establish the cause of eosinophilia. Recently, toxocariasis was introduced as one cause of eosinophilia. The aims of this study were to evaluate the prevalence of toxocariasis and the clinical impact of albendazole treatment for toxocariasis in patients suspected of eosinophilia of unknown origin. Methods: We performed a retrospective chart review. After evaluation of cause of eosinophilia, the patients suspected of eosinophilia of unknown origin performed immunoglobulin G antibody specific assay for the Toxocara canis larval antigen by enzyme-linked immunosorbent assay. Results: This study evaluated 113 patients, 69 patients (61%) were suspected of eosinophilia of unknown origin. Among these 69 patients, the frequency of T. canis infection was very high (45 patients, 65.2%), and albendazole treatment for 45 eosinophilia with toxocariasis was highly effective for a cure of eosinophilia than no albendazole group regardless of steroid (82.3%, p = 0.007). Furthermore, among the nonsteroid treated small group (19 patients), albendazole treatment for eosinophilia were more effective than no albendazole group, too (83.3% vs. 28.6 %, p = 0.045). Conclusions: The prevalence of toxocariasis was high among patients suspected of eosinophilia of unknown origin; therefore, evaluation for T. canis infection is recommended for patients with eosinophilia of unknown origin. Furthermore, for patients suspected of eosinophilia of unknown origin who have positive results for T. canis, albendazole treatment may be considered a valuable treatment option.
Abstract
Background/Aims: Eosinophilia has numerous diverse causes, and in many patients, it is not possible to establish the cause of eosinophilia. Recently, toxocariasis was introduced as one cause of eosinophilia. The aims of this study were to evaluate the prevalence of toxocariasis and the clinical impact of albendazole treatment for toxocariasis in patients suspected of eosinophilia of unknown origin. Methods: We performed a retrospective chart review. After evaluation of cause of eosinophilia, the patients suspected of eosinophilia of unknown origin performed immunoglobulin G antibody specific assay for the Toxocara canis larval antigen by enzyme-linked immunosorbent assay. Results: This study evaluated 113 patients, 69 patients (61%) were suspected of eosinophilia of unknown origin. Among these 69 patients, the frequency of T. canis infection was very high (45 patients, 65.2%), and albendazole treatment for 45 eosinophilia with toxocariasis was highly effective for a cure of eosinophilia than no albendazole group regardless of steroid (82.3%, p = 0.007). Furthermore, among the nonsteroid treated small group (19 patients), albendazole treatment for eosinophilia were more effective than no albendazole group, too (83.3% vs. 28.6 %, p = 0.045). Conclusions: The prevalence of toxocariasis was high among patients suspected of eosinophilia of unknown origin; therefore, evaluation for T. canis infection is recommended for patients with eosinophilia of unknown origin. Furthermore, for patients suspected of eosinophilia of unknown origin who have positive results for T. canis, albendazole treatment may be considered a valuable treatment option.
참고문헌 (20)
- Akao N, "Toxocariasis in Japan", Parasitol Int, 56, pp.87~93 (2007)
- Morris PD, "Human toxocariasis: review with report of a probable case", Postgrad Med, 81, pp.263~267 (1987)
- Despommier D., "Toxocariasis: clinical aspects, epidemiology, medical ecology, and molecular aspects", Clin Microbiol Rev, 16, pp.265~272 (2003)
- Johkoh T, "Eosinophilic lung diseases: diagnostic accuracy of thin-section CT in 111patients", Radiology, 216, pp.773~780 (2000)
- Obwaller A, "Toxocara infestations in humans: symptomatic course of toxocarosis correlates significantly with levels of IgE", anti-IgE immune complexes, 1998, pp.20, 311~317
- Kwon NH, "The prevalence and diagnostic value of toxocariasis in unknown eosinophilia", Ann Hematol, 85, pp.233~238 (2006)
- Arias Irigoyen J, "Toxocariasis: a cause of hyper IgE and eosinophilia", J Investig Allergol Clin Immunol, 5, pp.232~234 (1995)
- van Assendelft OW., "Reference values for the total and differential leukocyte count", Blood Cells, 11, pp.77~96 (1985)
- Roufosse F, "Practical approach to the patient with hypereosinophilia", J Allergy Clin Immunol, 126, pp.39~44 (2010)
- Brito-Babapulle F., "The eosinophilias, including the idiopathic hypereosinophilic syndrome", Br J Haematol, 121, pp.203~223 (2003)
- Roldan W, "Evaluation of the dot enzyme-linked immunosorbent assay in comparison with standard ELISA for the immunodiagnosis of human toxocariasis", Mem Inst Oswaldo Cruz, 101, pp.71~74 (2006)
- 김다운, "일개 대학병원 환자에서 과다호산구증가증의 빈도 및 원인 분석", Annals of Laboratory Medicine, 29(3), pp.185~193 (2009), 대한진단검사의학회
- 임재훈, "Eosinophilic Infiltration in Korea: Idiopathic?", Korean Journal of Radiology, 7(1), pp.4~6 (2006), 대한영상의학회
- Pawlowski Z., "Toxocariasis in humans: clinical expression and treatment dilemma", J Helminthol, 75, pp.299~305 (2001)
- 김용헌, "Seroprevalence of Toxocariasis among Healthy People with Eosinophilia", The Korean Journal of Parasitology, 46(1), pp.29~32 (2008), 대한기생충학ㆍ열대의학회
- Magnaval JF, "Epidemiology of human toxocariasis in La Reunion", Trans R Soc Trop Med Hyg, 88, pp.531~533 (1994)
- Malla N, "A serological study of human toxocariasis in north India", Natl Med J India, 15, pp.145~147 (2002)
- Jernej LOGAR, "Seroprevalence of Toxocara antibodies among patients suspected of ocular toxocariasis in Slovenia (Brief Communication)", The Korean Journal of Parasitology, 42(3), pp.137~140 (2004), 대한기생충학ㆍ열대의학회
- Stensvold CR, "Seroprevalence of human toxocariasis in Denmark", Clin Vaccine Immunol, 16, pp.1372~1373 (2009)
- 윤영순, "Impact of Toxocariasis in Patients with Unexplained Patchy Pulmonary Infiltrate in Korea", Journal of Korean Medical Science, 24(1), pp.40~45 (2009), 대한의학회