Seroepidemiology of Toxocariasis and Its Clinical Implications in Gwangju and Jeonnam-province, Korea
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
We investigated the seroepidemiological, clinical, and laboratory characteristics of patients suspected to have toxocariasis in Gwangju and Jeonnam-province, Korea. In total, 228 specimens were analyzed for anti-Toxocara canis IgG at two university hospitals from 2010 to 2012. The overall seropositive rate was 67.1%, and the seropositive rates among the eosinophilic and non-eosinophilic groups were 76.1% (105/138) and 53.3% (48/90), respectively. Risk factors for eosinophilia and toxocariasis were male sex (odds ratios [OR]=2.632 and 3.477, respectively) and a history of ingesting raw meat (OR=2.884 and 3.274, respectively), especially raw cow liver (OR=2.089 and 10.038, respectively). T. canis seropositivity (OR=5.807, P=0.004) and a history of consuming raw cow liver (OR=2.766, P=0.052) were risk factors for organ involvement. The anti-T. canis IgG level showed weakly positive correlations with eosinophil counts (r=0.234, P<0.001) and the duration of eosinophilia (r=0.155, P=0.019). Although limited to the regions of Gwangju and Jeonnam-province, this study supports the opinion that toxocariasis is a reasonable focus as a cause of eosinophilia and that it is also associated with organ involvement.
Abstract
We investigated the seroepidemiological, clinical, and laboratory characteristics of patients suspected to have toxocariasis in Gwangju and Jeonnam-province, Korea. In total, 228 specimens were analyzed for anti-Toxocara canis IgG at two university hospitals from 2010 to 2012. The overall seropositive rate was 67.1%, and the seropositive rates among the eosinophilic and non-eosinophilic groups were 76.1% (105/138) and 53.3% (48/90), respectively. Risk factors for eosinophilia and toxocariasis were male sex (odds ratios [OR]=2.632 and 3.477, respectively) and a history of ingesting raw meat (OR=2.884 and 3.274, respectively), especially raw cow liver (OR=2.089 and 10.038, respectively). T. canis seropositivity (OR=5.807, P=0.004) and a history of consuming raw cow liver (OR=2.766, P=0.052) were risk factors for organ involvement. The anti-T. canis IgG level showed weakly positive correlations with eosinophil counts (r=0.234, P<0.001) and the duration of eosinophilia (r=0.155, P=0.019). Although limited to the regions of Gwangju and Jeonnam-province, this study supports the opinion that toxocariasis is a reasonable focus as a cause of eosinophilia and that it is also associated with organ involvement.
참고문헌 (20)
- Rothenberg ME, "Eosinophilia", N Engl J Med, 338, pp.1592~1600 (1998)
- 서민, "A Seroepidemiological Survey of Toxocariasis among Eosinophilia Patients in Chungcheongnam-do", The Korean Journal of Parasitology, 50(3), pp.249~251 (2012), 대한기생충학ㆍ열대의학회
- Macpherson CN, "The epidemiology and public health importance of toxocariasis : a zoonosis of global importance", Int J Parasitol, 43, pp.999~1008 (2013)
- Mendonça LR, "Seroprevalence and risk factors for Toxocara infection in children from an urban large setting in Northeast Brazil", Acta Trop, 128, pp.90~95 (2013)
- Romero Núñez C, "Prevalence and risk factors associated with Toxocara canis infection in children", ScientificWorldJournal, 2013, pp.572089~ (2013)
- Maraghi S, "Seroprevalence of toxocariasis in hypereosinophilic individuals in Ahwaz, south-western Iran", J Helminthol, 86, pp.241~244 (2012)
- Woodhall DM, "Neglected parasitic infections in the United States: toxocariasis", Am J Trop Med Hyg, 90, pp.810~813 (2014)
- 류병한, "포항 지역의 톡소카라증의 임상적, 혈청학적 특징에 관한 연구: 포항의 톡소카라증의 특징", 대한내과학회지, 84(2), pp.203~210 (2013), 대한내과학회[DOI]
- 최동일, "Toxocariasis and Ingestion of Raw Cow Liver in Patients with Eosinophilia", The Korean Journal of Parasitology, 46(3), pp.139~143 (2008), 대한기생충학ㆍ열대의학회
- Jacquier P, "Immunodiagnosis of toxocarosis in humans: evaluation of a new enzyme-linked immunosorbent assay kit", J Clin Microbiol, 29, pp.1831~1835 (1991)
- Dancey C, "Statistics without maths for psychology : using SPSS for Windows" (2004), Prentice Hall
- Hotez PJ, "Toxocariasis: America’s most common neglected infection of poverty and a helminthiasis of global importance?", PLoS Negl Trop Dis, 3, pp.e400~ (2009)
- Kwon NH, "The prevalence and diagnostic value of toxocariasis in unknown eosinophilia", Ann Hematol, 85, pp.233~238 (2006)
- Hyun-YoungPARK, "A seroepidemiological survey for toxocariasis in apparently healthy residents in Gangwon-do, Korea", The Korean Journal of Parasitology, 40(3), pp.113~117 (2002), 대한기생충학ㆍ열대의학회
- 박한정, "호산구증가증 환자에서 Toxocara canis에 대한 특이 IgE 항체의 진단적 의의", 천식 및 알레르기, 29(2), pp.105~111 (2009), 대한천식알레르기학회
- 전형일, "Successful Control of Lymphatic Filariasis in the Republic of Korea", The Korean Journal of Parasitology, 47(4), pp.323~335 (2009), 대한기생충학ㆍ열대의학회
- 임재훈, "Foodborne Eosinophilia due to Visceral Larva Migrans: A Disease Abandoned", Journal of Korean Medical Science, 27(1), pp.1~2 (2012), 대한의학회
- Li L, "Asthma and toxocariasis", Ann Allergy Asthma Immunol, 113, pp.187~192 (2014)
- Kang YR, "Toxocariasis as a cause of new pulmonary infiltrates", Int J Tuberc Lung Dis, 17, pp.412~417 (2013)
- Magnaval JF, "Eosinophil cationic protein as a possible marker of active human Toxocara infection", Allergy, 56, pp.1096~1099 (2001)