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Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need

Kyung-Do Han|Nam Hoon Kim|Tae Seo Sohn|Ye Seul Yang
대한내과학회 (The Korean Association Of Internal Medicine)|2021.09|The Korean Journal of Internal Medicine|제36권 제5호|pp. 1049-1058|DOI https://doi.org/10.3904/kjim.2021.379

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키워드

EpidemiologyDiabetes mellitusYoung adulttype 2Treatment adherence and complianceDiabetes complications
주제분류내과학

초록

The prevalence of young-onset (diagnosis at age < 40 years) type 2 diabetes mellitus (T2DM) is increasing globally. Young-onset T2DM has a common pathophysiology of glucose dysregulation as in late-onset T2DM. However, it presents a greater association with obesity and a more rapid decline in β-cell function than late-onset T2DM. Accumulating evidence indicates that disease progression in young-onset T2DM is rapid, resulting in early and frequent development of microvascular and macrovascular complications, as well as premature death. Improper management and low adherence to medical therapy are important issues in young-onset T2DM. This review discusses the epidemiology, disease entity, and clinical issues associated with young-onset T2DM. We also present the prevalence and clinical characteristics of patients with young-onset T2DM in South Korea.

Abstract

The prevalence of young-onset (diagnosis at age < 40 years) type 2 diabetes mellitus (T2DM) is increasing globally. Young-onset T2DM has a common pathophysiology of glucose dysregulation as in late-onset T2DM. However, it presents a greater association with obesity and a more rapid decline in β-cell function than late-onset T2DM. Accumulating evidence indicates that disease progression in young-onset T2DM is rapid, resulting in early and frequent development of microvascular and macrovascular complications, as well as premature death. Improper management and low adherence to medical therapy are important issues in young-onset T2DM. This review discusses the epidemiology, disease entity, and clinical issues associated with young-onset T2DM. We also present the prevalence and clinical characteristics of patients with young-onset T2DM in South Korea.

참고문헌 (47)

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관련 논문AI추천

Trends in the prevalence and management of diabetes in Korea: 2007-2017신지연한국역학회 · Epidemiology and Health2019 · 제41권 Associations among Body Mass Index, Insulin Resistance, and Pancreatic ß-Cell Function in Korean Patients with New-Onset Type 2 Diabetes정동진, 정민영, 정진욱, 조동혁대한내과학회 · The Korean Journal of Internal Medicine2012 · 제27권 제1호Questionnaire-Based Survey of Diabetes Self-Care Activities and Barriers among Young Korean Adults with Early-Onset Diabetes김상욱, 박지인, 송기호, 유지희, 정지윤, 조은희, 남궁일성연세대학교의과대학 · Yonsei Medical Journal2024 · 제65권 제1호Antihyperglycemic agent therapy for adult patients with type 2 diabetes mellitus 2017: a position statement of the Korean Diabetes Association고승현, 김난희, 김진화, 김현진, 문민경, 박석오, 이병완, 이상열, 최경묵, 허규연, the Committee of Clinical Practice Guideline of KDA대한내과학회 · The Korean Journal of Internal Medicine2017 · 제32권 제6호Analysis of diabetes quality assessment findings and future directions for the appropriate management of diabetes in Korea존석, 김성운, 김유진, 오승준, 우정택, 이상열대한내과학회 · The Korean Journal of Internal Medicine2019 · 제34권 제1호Comprehensive approaches to diabetes in the elderly: adapting to evolving trendsBong-Soo Cha, Chang Oh Kim, Hee-Won Jung, Hun-Sung Kim, Jeongmin Lee, Kwang Joon Kim, Kyeong Hye Park, Yang Sun Park, Yong-ho Lee대한내과학회 · The Korean Journal of Internal Medicine2025 · 제40권 제6호

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