Associations among Body Mass Index, Insulin Resistance, and Pancreatic ß-Cell Function in Korean Patients with New-Onset Type 2 Diabetes
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Background/Aims: We investigated the associations among body mass index (BMI), insulin resistance, and β-cell function in Korean patients newly presenting with type 2 diabetes. Methods: In total, 132 patients with new-onset type 2 diabetes mellitus were investigated. A standard 75-g oral glucose tolerance test was performed, and the indices of insulin secretion and insulin resistance were calculated. Results: A higher BMI was associated with higher homeostasis model assessment values for insulin resistance (HOMAIR), homeostasis model assessment of β-cell function (HOMA-β), and insulinogenic index as well as lower levels of insulin sensitivity index composite (ISIcomp) and disposition index (DI). In multiple regression models, BMI had independent positive associations with HOMA-IR, ISIcomp, and HOMA-β and inverse associations with the DI. Conclusions: Our results showed that BMI had independent positive associations with indices of insulin resistance and an inverse association with β-cell function adjusted for insulin resistance in Korean patients newly presenting with type 2 diabetes.
Abstract
Background/Aims: We investigated the associations among body mass index (BMI), insulin resistance, and β-cell function in Korean patients newly presenting with type 2 diabetes. Methods: In total, 132 patients with new-onset type 2 diabetes mellitus were investigated. A standard 75-g oral glucose tolerance test was performed, and the indices of insulin secretion and insulin resistance were calculated. Results: A higher BMI was associated with higher homeostasis model assessment values for insulin resistance (HOMAIR), homeostasis model assessment of β-cell function (HOMA-β), and insulinogenic index as well as lower levels of insulin sensitivity index composite (ISIcomp) and disposition index (DI). In multiple regression models, BMI had independent positive associations with HOMA-IR, ISIcomp, and HOMA-β and inverse associations with the DI. Conclusions: Our results showed that BMI had independent positive associations with indices of insulin resistance and an inverse association with β-cell function adjusted for insulin resistance in Korean patients newly presenting with type 2 diabetes.
참고문헌 (25)
- Ferrannini E, "Insulin resistance versus insulin deficiency in non-insulin-dependent diabetes mellitus: problems and prospects", Endocr Rev, 19, pp.477~490 (1998)
- DeFronzo RA, "Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM", Diabetes, 37, pp.667~687 (1988)
- 이기업, "Past and current obesity in Koreans with non-insulin-dependent diabetes mellitus", DIABETES RESEARCH AND CLINICAL PRACTICE, 35(1), pp.49~56, ELSEVIER SCI IRELAND LTD
- 이상열, "The Changes in Early Phase Insulin Secretion in Newly Diagnosed, Drug Naive Korean Prediabetes Subjects", Diabetes and Metabolism Journal, 34(3), pp.157~165 (2010), 대한당뇨병학회
- Kim DJ, "Insulin secretory dysfunction and insulin resistance in the pathogenesis of Korean type 2 diabetes mellitus", Metabolism, 50, pp.590~593 (2001)
- Funakoshi S, "Analysis of factors influencing pancreatic beta-cell function in Japanese patients with type 2 diabetes: association with body mass index and duration of diabetic exposure", Diabetes Res Clin Pract, 82, pp.353~358 (2008)
- Juang JH, "C-peptide response to glucagon in patients with non-insulin-dependent diabetes mellitus", J Formos Med Assoc, 91, pp.491~496 (1992)
- Chang SA, "Body mass index is the most important determining factor for the degree of insulin resistance in non-obese type 2 diabetic patients in Korea", Metabolism, 53, pp.142~146 (2004)
- American Diabetes Association, "Diagnosis and classification of diabetes mellitus", Diabetes Care, 31(Suppl 1), pp.S55~S60 (2008)
- Matthews DR, "Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man", Diabetologia, 28, pp.412~419 (1985)
- Matsuda M, "Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp", Diabetes Care, 22, pp.1462~1470 (1999)
- Seltzer HS, "Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus", J Clin Invest, 46, pp.323~335 (1967)
- Kahn SE, "Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects: evidence for a hyperbolic function", Diabetes, 42, pp.1663~1672 (1993)
- Bergman RN, "Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose", J Clin Invest, 68, pp.1456~1467 (1981)
- Finegood DT, "A modified protocol for estimation of insulin sensitivity with the minimal model of glucose kinetics in patients with insulin-dependent diabetes", J Clin Endocrinol Metab, 70, pp.1538~1549 (1990)
- Hermans MP, "Comparison of tests of beta-cell function across a range of glucose tolerance from normal to diabetes", Diabetes, 48, pp.1779~1786 (1999)
- Kim SM, "Prevalence of diabetes and impaired fasting glucose in Korea", DIABETES CARE, 29(2), pp.226~231, AMER DIABETES ASSOC
- Qiao Q, "Is the association of type II diabetes with waist circumference or waist-to-hip ratio stronger than that with body mass index?", Eur J Clin Nutr, 64, pp.30~34 (2010)
- Sung EJ, "Obesity as a risk factor for non-insulin-dependent diabetes mellitus in Korea", J Korean Med Sci, 16, pp.391~396 (2001)
- Campbell PJ, "Impact of obesity on insulin action in NIDDM", Diabetes, 42, pp.405~410 (1993)
- Butler AE, "Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes", Diabetes, 52, pp.102~110 (2003)
- Yoon KH, "Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea", J Clin Endocrinol Metab, 88, pp.2300~2308 (2003)
- Pontiroli AE, "Secondary failure to oral hypoglycaemic agents in non-obese patients with non-insulin- dependent diabetes is related to reduced insulin release", Diabete Metab, 15, pp.79~84 (1989)
- Arner P, "Different aetiologies of type 2(non-insulin-dependent) diabetes mellitus in obese and nonobesesubjects", Diabetologia, 34, pp.483~487 (1991)
- Roy MN, "Determinants of insulin secretion and sensitivity in Bangladeshi type 2 diabetic subjects", Metab Syndr Relat Disord, 5, pp.275~281 (2007)