Association between knee osteoarthritis and mortality: a serial propensity score-matched cohort study
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background/Aims: The association between symptomatic knee osteoarthritis (OA) and higher cardiovascular disease (CVD) mortality is established; however, findings from studies that utilized regression analysis were limited, attributed to the strong association between OA and metabolic risk factors. This study aimed to evaluate the association between knee OA and mortality through propensity score matching. Methods: This was a cohort study including Korean National Health and Nutrition Examination Survey (2010–2013) participants aged ≥ 50 years. By linking the survey data to cause of death data (through 2019) from Statistics Korea, mortality and cause-specific mortality data were obtained. Radiographic knee OA (ROA) was defined as bilateral Kellgren–Lawrence grade ≥ 2. Propensity score matching (1:1) was conducted between asymptomatic ROA, knee pain, and symptomatic ROA groups and normal groups, balancing the confounding factors. Time to death was analyzed using Cox proportional hazard modeling. Results: A higher CVD mortality was observed in the symptomatic ROA group, but not in others; the risk estimates were asymptomatic ROA (hazard ratio [HR] 1.12; 95% confidence interval [CI] 0.77–1.65), knee pain (HR 0.61; 95% CI 0.27–1.38), and symptomatic ROA (HR 1.39; 95% CI 0.89–2.17). No association was found between the all-cause/cancer mortality and other groups. Conclusions: When propensity score matching controls metabolic risk factor imbalances, the association between symptomatic knee OA and higher CVD mortality was weaker compared to results of prior studies that used regression adjustment. The results may be more precise estimates of the total risk of knee OA for mortality in Koreans.
Abstract
Background/Aims: The association between symptomatic knee osteoarthritis (OA) and higher cardiovascular disease (CVD) mortality is established; however, findings from studies that utilized regression analysis were limited, attributed to the strong association between OA and metabolic risk factors. This study aimed to evaluate the association between knee OA and mortality through propensity score matching. Methods: This was a cohort study including Korean National Health and Nutrition Examination Survey (2010–2013) participants aged ≥ 50 years. By linking the survey data to cause of death data (through 2019) from Statistics Korea, mortality and cause-specific mortality data were obtained. Radiographic knee OA (ROA) was defined as bilateral Kellgren–Lawrence grade ≥ 2. Propensity score matching (1:1) was conducted between asymptomatic ROA, knee pain, and symptomatic ROA groups and normal groups, balancing the confounding factors. Time to death was analyzed using Cox proportional hazard modeling. Results: A higher CVD mortality was observed in the symptomatic ROA group, but not in others; the risk estimates were asymptomatic ROA (hazard ratio [HR] 1.12; 95% confidence interval [CI] 0.77–1.65), knee pain (HR 0.61; 95% CI 0.27–1.38), and symptomatic ROA (HR 1.39; 95% CI 0.89–2.17). No association was found between the all-cause/cancer mortality and other groups. Conclusions: When propensity score matching controls metabolic risk factor imbalances, the association between symptomatic knee OA and higher CVD mortality was weaker compared to results of prior studies that used regression adjustment. The results may be more precise estimates of the total risk of knee OA for mortality in Koreans.
참고문헌 (34)
- Lee S, "Prevalence of knee osteoarthritis, risk factors, and quality of life : the Fifth Korean National Health And Nutrition Examination Survey", Int J Rheum Dis, 20, pp.809~817 (2017)
- Dillon CF, "Prevalence of knee osteoarthritis in the United States : arthritis data from the Third National Health and Nutrition Examination Survey 1991-94", J Rheumatol, 33, pp.2271~2279 (2006)
- Spitaels D, "Epidemiology of knee osteoarthritis in general practice : a registry-based study", BMJ Open, 10, pp.e031734~ (2020)
- Nüesch E, "All cause and disease specific mortality in patients with knee or hip osteoarthritis : population based cohort study", BMJ, 342, pp.d1165~ (2011)
- Mendy A, "Osteoarthritis and risk of mortality in the USA : a population-based cohort study", Int J Epidemiol, 47, pp.1821~1829 (2018)
- Kluzek S, "Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23 years follow-up of a population-based cohort of middle-aged women", Ann Rheum Dis, 75, pp.1749~1756 (2016)
- Cleveland RJ, "The impact of painful knee osteoarthritis on mortality : a community-based cohort study with over 24 years of follow-up", Osteoarthritis Cartilage, 27, pp.593~602 (2019)
- Liu Q, "Knee osteoarthritis and all-cause mortality : the Wuchuan Osteoarthritis Study", Osteoarthritis Cartilage, 23, pp.1154~1157 (2015)
- Leyland KM, "Knee osteoarthritis and time-to all-cause mortality in six community-based cohorts: an international meta-analysis of individual participant-level data", Aging Clin Exp Res, 33, pp.529~545 (2021)
- Zhuo Q, "Metabolic syndrome meets osteoarthritis", Nat Rev Rheumatol, 8, pp.729~737 (2012)
- Rubin DB, "Using Propensity scores to help design observational studies : application to the tobacco litigation", Health Serv Outcomes Res Methodol, 2, pp.169~188 (2001)
- Choi HK, "Selection bias in rheumatic disease research", Nat Rev Rheumatol, 10, pp.403~412 (2014)
- Dahabreh IJ, "Index event bias as an explanation for the paradoxes of recurrence risk research", JAMA, 305, pp.822~823 (2011)
- Adamopoulos C, "Absence of obesity paradox in patients with chronic heart failure and diabetes mellitus : a propensity-matched study", Eur J Heart Fail, 13, pp.200~206 (2011)
- Lipsitch M, "Negative controls : a tool for detecting confounding and bias in observational studies", Epidemiology, 21, pp.383~388 (2010)
- Craig CL, "International physical activity questionnaire : 12-country reliability and validity", Med Sci Sports Exerc, 35, pp.1381~1395 (2003)
- Rabin R, "EQ-5D : a measure of health status from the EuroQol Group", Ann Med, 33, pp.337~343 (2001)
- "Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults--the evidence report. National Institutes of Health", Obes Res, 2(Suppl 2), pp.51S~209S (1998)
- Chobanian AV, "The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report", JAMA, 289, pp.2560~2572 (2003)
- American Diabetes Association, "2. Classification and diagnosis of diabetes : standards of medical care in diabetes-2018", Diabetes Care, 41(Suppl 1), pp.S13~S27 (2018)
- Kellgren JH, "Radiological assessment of osteo-arthrosis", Ann Rheum Dis, 16, pp.494~502 (1957)
- Atiquzzaman M, "Role of nonsteroidal antiinflammatory drugs in the association between osteoarthritis and cardiovascular diseases : a longitudinal study", Arthritis Rheumatol, 71, pp.1835~1843 (2019)
- Klimek M, "Long-term mortality of patients with osteoarthritis after joint replacement: prognostic value of preoperative and postoperative pain and function", Arthritis Care Res(Hoboken), 75, pp.869~875 (2023)
- Yapp LZ, "Long-term mortality rates and associated risk factors following primary and revision knee arthroplasty :107,121 patients from the Scottish Arthroplasty Project", Bone Joint J, 104-B, pp.45~52 (2022)
- Yeh HW, "Total knee replacement in osteoarthritis patients on reducing the risk of major adverse cardiac events : a 18-year retrospective cohort study", Osteoarthritis Cartilage, 30, pp.416~425 (2022)
- Myers J, "Physical activity, cardiorespiratory fitness, and the metabolic syndrome", Nutrients, 11, pp.1652~ (2019)
- American Heart Association, "Diagnosis and management of the metabolic syndrome. An American Heart Association", National Heart, Lung, and Blood Institute Scientific Statement. Executive summary, 2005, pp.13, 322~327
- White DK, "Do radiographic disease and pain account for why people with or at high risk of knee osteoarthritis do not meet physical activity guidelines?", Arthritis Rheum, 65, pp.139~147 (2013)
- Fransen M, "Exercise for osteoarthritis of the knee", Cochrane Database Syst Rev, 1, pp.CD004376~ (2015)
- Kolasinski SL, "2019 American College of Rheumatology", Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee, 2020, pp.72, 149~162
- Bannuru RR, "OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis", Osteoarthritis Cartilage, 27, pp.1578~1589 (2019)
- Greenland S, "Causal diagrams for epidemiologic research", Epidemiology, 10, pp.37~48 (1999)
- Robinson PC, "Insight into rheumatological cause and effect through the use of Mendelian randomization", Nat Rev Rheumatol, 12, pp.486~496 (2016)
- Roos EM, "Strategies for the prevention of knee osteoarthritis", Nat Rev Rheumatol, 12, pp.92~101 (2016)