The Insertion/Deletion Polymorphism of Angiotensin I Converting Enzyme Gene is Associated With Ossification of the Posterior Longitudinal Ligament in the Korean Population
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Objective To determine whether ACE insertion/deletion (I/D) polymorphism is associated with the ossification of the posterior longitudinal ligament (OPLL) of the spine in the Korean population.Methods A case-control study was conducted to investigate the association between I/D polymorphism of the angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (ACE) gene and OPLL. The 95 OPLL patients and 274 control subjects were recruited. Polymerase chain reaction for the genotyping of ACE I/D polymorphism was performed. The difference between the OPLL patients and the control subjects was compared using the contingency χ2 test and the logistic regression analysis. For statistical analysis, SPSS, SNPStats, SNPAnalyzer, and Helixtree programs were used.Results The genotype and allele frequencies of ACE I/D polymorphism showed significant differences between the OPLL patients and the control subjects (genotype, p<0.001; allele, p=0.009). The frequencies of D/D genotype and D allele in the OPLL group were higher than those in the control group. In logistic regression analysis, ACE I/D polymorphism was associated with OPLL (dominant model; p=0.002; odd ratio, 2.20; 95% confidence interval, 1.33-3.65). Conclusion These results suggest that the deletion polymorphism of the ACE gene may be a risk factor for the development of OPLL in the Korean population.
Abstract
Objective To determine whether ACE insertion/deletion (I/D) polymorphism is associated with the ossification of the posterior longitudinal ligament (OPLL) of the spine in the Korean population.Methods A case-control study was conducted to investigate the association between I/D polymorphism of the angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 (ACE) gene and OPLL. The 95 OPLL patients and 274 control subjects were recruited. Polymerase chain reaction for the genotyping of ACE I/D polymorphism was performed. The difference between the OPLL patients and the control subjects was compared using the contingency χ2 test and the logistic regression analysis. For statistical analysis, SPSS, SNPStats, SNPAnalyzer, and Helixtree programs were used.Results The genotype and allele frequencies of ACE I/D polymorphism showed significant differences between the OPLL patients and the control subjects (genotype, p<0.001; allele, p=0.009). The frequencies of D/D genotype and D allele in the OPLL group were higher than those in the control group. In logistic regression analysis, ACE I/D polymorphism was associated with OPLL (dominant model; p=0.002; odd ratio, 2.20; 95% confidence interval, 1.33-3.65). Conclusion These results suggest that the deletion polymorphism of the ACE gene may be a risk factor for the development of OPLL in the Korean population.
참고문헌 (26)
- Inamasu J, "Ossification of the posterior longitudinal ligament: an update on its biology, epidemiology, and natural history", Neurosurgery, 58, pp.1027~1039 (2006)
- Matsunaga S, "Genetic analysis of ossification of the posterior longitudinal ligament", Spine (Phila Pa 1976), 24, pp.937~938 (1999)
- Mizuno J, "Ossified posterior longitudinal ligament: management strategies and outcomes", Spine J, 6(6 Suppl), pp.282S~288S (2006)
- Koga H, "Genetic mapping of ossification of the posterior longitudinal ligament of the spine", Am J Hum Genet, 62, pp.1460~1467 (1998)
- Sakou T, "Genetic study of ossification of the posterior longitudinal ligament in the cervical spine with human leukocyte antigen haplotype", Spine (Phila Pa 1976), 16, pp.1249~1252 (1991)
- Kong Q, "COL6A1 polymorphisms associated with ossification of the ligamentum flavum and ossification of the posterior longitudinal ligament", Spine (Phila Pa 1976), 32, pp.2834~2838 (2007)
- Koga H, "Restriction fragment length polymorphism of genes of the alpha 2(XI) collagen, bone morphogenetic protein-2, alkaline phosphatase, and tumor necrosis factor-alpha among patients with ossification of posterior longitudinal ligament and controls from the Japanese population", Spine (Phila Pa 1976), 21, pp.469~473 (1996)
- Maeda S, "Gender-specific haplotype association of collagen alpha2 (XI) gene in ossification of the posterior longitudinal ligament of the spine", J Hum Genet, 46, pp.1~4 (2001)
- Maeda S, "Functional impact of human collagen alpha2(XI) gene polymorphism in pathogenesis of ossification of the posterior longitudinal ligament of the spine", J Bone Miner Res, 16, pp.948~957 (2001)
- Horikoshi T, "A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine", Hum Genet, 119, pp.611~616 (2006)
- Furushima K, "Large-scale screening for candidate genes of ossification of the posterior longitudinal ligament of the spine", J Bone Miner Res, 17, pp.128~137 (2002)
- Nakamura I, "Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL)", Hum Genet, 104, pp.492~497 (1999)
- Koshizuka Y, "Nucleotide pyrophosphatase gene polymorphism associated with ossification of the posterior longitudinal ligament of the spine", J Bone Miner Res, 17, pp.138~144 (2002)
- Ogata N, "Association of bone metabolism regulatory factor gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity", Spine (Phila Pa 1976), 27, pp.1765~1771 (2002)
- Tahara M, "The extent of ossification of posterior longitudinal ligament of the spine associated with nucleotide pyrophosphatase gene and leptin receptor gene polymorphisms", Spine (Phila Pa 1976), 30, pp.877~880 (2005)
- Kawaguchi Y, "Association between polymorphism of the transforming growth factor-beta1 gene with the radiologic characteristic and ossification of the posterior longitudinal ligament", Spine (Phila Pa 1976), 28, pp.1424~1426 (2003)
- Viitanen L, "Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease", Atherosclerosis, 157, pp.57~64 (2001)
- Costerousse O, "Genetics of angiotensin I-converting enzyme", Clin Exp Hypertens, 19, pp.659~669 (1997)
- Ban JY, "Promoter polymorphism (rs3755724, -55C", T) of tissue inhibitor of metalloproteinase 4 (TIMP4) as a risk factor for Kawasaki disease with coronary artery lesions in a Korean population, 2009, pp.30, 331~335
- 정미영, "Assessment of Relationship between Fyn-related Kinase Gene Polymorphisms and Overweight", Obesity in Korean Population, 2008, pp.12(2), 83~87[DOI]
- Onji Y, "Posterior paravertebral ossification causing cervical myelopathy: a report of eighteen cases", J Bone Joint Surg Am, 49, pp.1314~1328 (1967)
- Tsuyama N, "Ossification of the posterior longitudinal ligament of the spine", Clin Orthop Relat Res, (184), pp.71~84 (1984)
- Tanaka T, "Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine", Am J Hum Genet, 73, pp.812~822 (2003)
- Rigat B, "An insertion", deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels, 1990, pp.86, 1343~1346
- Rigat B, "PCR detection of the insertion", deletion polymorphism of the human angiotensin converting enzyme gene (DCP1)(dipeptidyl carboxypeptidase 1), 1992, pp.20, 1433~
- Yoshida H, "Role of the deletion of polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy", J Clin Invest, 96, pp.2162~2169 (1995)