Acute Cerebral Infarction as a Rare Thrombotic Event in Myelodysplastic Syndrome: A Case Report
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Myelodysplastic syndrome (MDS) is a bone marrow failure syndrome characterized by cytopenia that results in high risks of infection and bleeding. However, there are few reports of cerebral infarction in MDS. We reported a 72-year-old female with MDS who developed acute cerebral infarction. Clinical history of the patient revealed no definite risk factors for stroke except diabetes mellitus and dyslipidemia that was well controlled. This case represented the rare occurrence of arterial thrombosis causing acute cerebral infarction in MDS, which may be due to complex chromosomal abnormality and inflammatory processes.
Abstract
Myelodysplastic syndrome (MDS) is a bone marrow failure syndrome characterized by cytopenia that results in high risks of infection and bleeding. However, there are few reports of cerebral infarction in MDS. We reported a 72-year-old female with MDS who developed acute cerebral infarction. Clinical history of the patient revealed no definite risk factors for stroke except diabetes mellitus and dyslipidemia that was well controlled. This case represented the rare occurrence of arterial thrombosis causing acute cerebral infarction in MDS, which may be due to complex chromosomal abnormality and inflammatory processes.
참고문헌 (9)
- Bennett JM, "The myelodysplastic syndromes: morphology, risk assessment, and clinical management (2002)", Int J Hematol, 76(Suppl 2), pp.228~238 (2002)
- Yang X, "Venous thromboembolism in myelodysplastic syndrome patients receiving lenalidomide: results from postmarketing surveillance and data mining techniques", Clin Drug Investig, 29, pp.161~171 (2009)
- Smith SW, "Erythropoiesis-stimulating agents are not associated with increased risk of thrombosis in patients with myelodysplastic syndromes", Haematologica, 97, pp.15~20 (2012)
- "VIDAZA: azacitidine injection, powder, lyophilized, for solution"[URL]
- American Diabetes Association, "Older adults", Diabetes Care, 39(Suppl 1), pp.S81~S85 (2016)
- D’Agostino RB, "Stroke risk profile: adjustment for antihypertensive medication. The Framingham Study", Stroke, 25, pp.40~43 (1994)
- Kimura S, "Trisomy 8 involved in myelodysplastic syndromes as a risk factor for intestinal ulcers and thrombosis:Behcet’s syndrome", Leuk Lymphoma, 42, pp.115~121 (2001)
- Hsu HC, "Circulating levels of thrombopoietic and inflammatory cytokines in patients with acute myeloblastic leukemia and myelodysplastic syndrome", Oncology, 63, pp.64~69 (2002)
- Chen G, "Distinctive gene expression profiles of CD34 cells from patients with myelodysplastic syndrome characterized by specific chromosomal abnormalities", Blood, 104, pp.4210~4218 (2004)