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A Case of Refractory Thrombocytopenia with 5q Deletion: Myelodysplastic Syndrome Mimicking Idiopathic Thrombocytopenic Purpura

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참고문헌

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초록

Refractory thrombocytopenia (RT), classified by the WHO as a subtype of refractory cytopenia with unilineage dysplasia, is an unusual MDS subtype that initially presents as chronic pure thrombocytopenia [1]. RT is often misdiagnosed as idiopathic thrombocytopenic purpura (ITP) becausethe dysplasiain ITP is indistinguishable from that in RT [2].

Abstract

Refractory thrombocytopenia (RT), classified by the WHO as a subtype of refractory cytopenia with unilineage dysplasia, is an unusual MDS subtype that initially presents as chronic pure thrombocytopenia [1]. RT is often misdiagnosed as idiopathic thrombocytopenic purpura (ITP) becausethe dysplasiain ITP is indistinguishable from that in RT [2].

참고문헌 (8)

  1. Vardiman JW, "The World Health Organization (WHO) classification of tumors of the hematopoietic and lymphoid tissues: an overview with emphasis on the myeloid neoplasms", Chem Biol Interact, 184, pp.16~20 (2010)
  2. Cines DB, "Immune thrombocytopenic purpura", N Engl J Med, 346, pp.995~1008 (2002)
  3. Sashida G, "Clinico-hematologic features of myelodysplastic syndrome presenting as isolated thrombocytopenia: an entity with a relatively favorable prognosis", Leuk Lymphoma, 44, pp.653~658 (2003)
  4. Giagounidis AA, "Clinical, morphological, cytogenetic, and prognostic features of patients with myelodysplastic syndromes and del(5q) including band q31", Leukemia, 18, pp.113~119 (2004)
  5. Menke DM, "Refractory thrombocytopenia. A myelodysplastic syndrome that may mimic immune thrombocytopenic purpura", Am J Clin Pathol, 98, pp.502~510 (1992)
  6. Pamuk GE, "Overview of 321 patients with idiopathic thrombocytopenic purpura. Retrospective analysis of the clinical features and response to therapy", Ann Hematol, 81, pp.436~440 (2002)
  7. Germing U, "Prospective validation of the WHO proposals for the classification of myelodysplastic syndromes", Haematologica, 91, pp.1596~1604 (2006)
  8. Sun Y, "Fluorescence in situ hybridization for del(5q) in myelodysplasia", acute myeloid leukemia: comparison of EGR1 vs. CSF1R probes and diagnostic yield over metaphase cytogenetics alone, 2010, pp.34, 340~343

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