Myelodysplastic Syndromes with Bone Marrow Fibrosis: An Update
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Myelodysplastic syndrome (MDS) is a diverse hematological malignancy with a wide spectrum of presentations and implications. Treatment strategies for patients with MDS heavily rely on prognostic scoring systems, such as the revised international prognostic scoring system (IPSS-R). Bone marrow fibrosis (BMF) has been identified as an independent risk factor for poor survival in patients with MDS, irrespective of the IPSS-R risk category. However, BMF is not widely included in scoring systems and is not always considered by clinicians when making treatment decisions for patients. In this review, we discuss the available literature about the presentation and prognosis of patients with MDS and concurrent BMF. The prognostic impact of BMF should be factored in when deciding on transplant candidacy, especially for intermediate-risk patients.
Abstract
Myelodysplastic syndrome (MDS) is a diverse hematological malignancy with a wide spectrum of presentations and implications. Treatment strategies for patients with MDS heavily rely on prognostic scoring systems, such as the revised international prognostic scoring system (IPSS-R). Bone marrow fibrosis (BMF) has been identified as an independent risk factor for poor survival in patients with MDS, irrespective of the IPSS-R risk category. However, BMF is not widely included in scoring systems and is not always considered by clinicians when making treatment decisions for patients. In this review, we discuss the available literature about the presentation and prognosis of patients with MDS and concurrent BMF. The prognostic impact of BMF should be factored in when deciding on transplant candidacy, especially for intermediate-risk patients.
참고문헌 (35)
- Kuter DJ, "Bone marrow fibrosis : pathophysiology and clinical significance of increased bone marrow stromal fibres", Br J Haematol, 139, pp.351~362 (2007)
- Gömöri G, "Silver impregnation of reticulum in paraffin sections", Am J Pathol, 13, pp.993~1002 (1937)
- Kvasnicka HM, "Bone marrow features improve prognostic efficiency in multivariate risk classification of chronic-phase Ph1+ chronic myelogenous leukemia : a multicenter trial", J Clin Oncol, 19, pp.2994~3009 (2001)
- Subramanian R, "Significance of bone marrow fibrosis in multiple myeloma", Pathology, 39, pp.512~515 (2007)
- Vener C, "Prognostic implications of the European consensus for grading of bone marrow fibrosis in chronic idiopathic myelofibrosis", Blood, 111, pp.1862~1865 (2008)
- Campbell PJ, "Reticulin accumulation in essential thrombocythemia : prognostic significance and relationship to therapy", J Clin Oncol, 27, pp.2991~2999 (2009)
- Sultan C, "Acute myelodysplasia with myelofibrosis : a report of eight cases", Br J Haematol, 49, pp.11~16 (1981)
- Arber DA, "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia", Blood, 127, pp.2391~2405 (2016)
- Pagliuca A, "Myelofibrosis in primary myelodysplastic syndromes : a clinico-morphological study of 10 cases", Br J Haematol, 71, pp.499~504 (1989)
- Della Porta MG, "Clinical relevance of bone marrow fibrosis and CD34-positive cell clusters in primary myelodysplastic syndromes", J Clin Oncol, 27, pp.754~762 (2009)
- Buesche G, "Marrow fibrosis predicts early fatal marrow failure in patients with myelodysplastic syndromes", Leukemia, 22, pp.313~322 (2008)
- Fu B, "Bone marrow fibrosis in patients with primary myelodysplastic syndromes has prognostic value using current therapies and new risk stratification systems", Mod Pathol, 27, pp.681~689 (2014)
- Lambertenghi-Deliliers G, "Myelodysplastic syndrome with increased marrow fibrosis : a distinct clinico-pathological entity", Br J Haematol, 78, pp.161~166 (1991)
- Greenberg PL, "Revised international prognostic scoring system for myelodysplastic syndromes", Blood, 120, pp.2454~2465 (2012)
- Vardiman JW, "The 2008 revision of the World Health Organization(WHO)classification of myeloid neoplasms and acute leukemia : rationale and important changes", Blood, 114, pp.937~951 (2009)
- Verhoef GE, "Myelodysplastic syndromes with bone marrow fibrosis : a myelodysplastic disorder with proliferative features", Ann Hematol, 63, pp.235~241 (1991)
- Della Porta MG, "Myelodysplastic syndromes with bone marrow fibrosis", Haematologica, 96, pp.180~183 (2011)
- Kröger N, "Allogeneic stem cell transplantation for myelodysplastic syndromes with bone marrow fibrosis", Haematologica, 96, pp.291~297 (2011)
- Tefferi A, "Pathogenesis of myelofibrosis with myeloid metaplasia", J Clin Oncol, 23, pp.8520~8530 (2005)
- Steensma DP, "Myelodysplasia with fibrosis : a distinct entity?", Leuk Res, 25, pp.829~838 (2001)
- Wang J, "Moderate to severe marrow fibrosis as a more advanced risk factor for MDS and MDS-AML patients with excess of blasts receiving allogeneic hematopoietic stem cell transplantation", Transplant Cell Ther, 27, pp.666~ (2021)
- Manoharan A, "The reticulin content of bone marrow in acute leukaemia in adults", Br J Haematol, 43, pp.185~190 (1979)
- Thiele J, "European consensus on grading bone marrow fibrosis and assessment of cellularity", Haematologica, 90, pp.1128~1132 (2005)
- Fu B, "The clinical importance of moderate", severe bone marrow fibrosis in patients with therapy-related myelodysplastic syndromes, 2013, pp.92, 1335~1343
- Melody M, "Decoding bone marrow fibrosis in myelodysplastic syndromes", Clin Lymphoma Myeloma Leuk, 20, pp.324~328 (2020)
- Ramos F, "Bone marrow fibrosis in myelodysplastic syndromes : a prospective evaluation including mutational analysis", Oncotarget, 7, pp.30492~30503 (2016)
- Marisavljević D, "Myelofibrosis in primary myelodysplastic syndromes : clinical and biological significance", Med Oncol, 21, pp.325~331 (2004)
- Ohyashiki K, "Clinical and cytogenetic characteristics of myelodysplastic syndromes developing myelofibrosis", Cancer, 68, pp.178~183 (1991)
- Allen EF, "A case of acute myelofibrosis with complex karyotypic changes : a type of myelodysplastic syndrome", Cancer Genet Cytogenet, 90, pp.24~28 (1996)
- Reilly JT, "Proposed classification for the myelodysplasia", myelofibrosis syndromes, 1991, pp.79, 653~
- Narayanan MN, "Hyperfibrotic myelodysplasia", Br J Haematol, 79, pp.653~655 (1991)
- Maschek H, "Myelofibrosis in primary myelodysplastic syndromes : a retrospective study of 352 patients", Eur J Haematol, 48, pp.208~214 (1992)
- Hussein K, "Profile of fibrosis-related gene transcripts and megakaryocytic changes in the bone marrow of myelodysplastic syndromes with fibrosis", Ann Hematol, 97, pp.2099~2106 (2018)
- Scott BL, "Marrow fibrosis as a risk factor for posttransplantation outcome in patients with advanced myelodysplastic syndrome or acute myeloid leukemia with multilineage dysplasia", Biol Blood Marrow Transplant, 13, pp.345~354 (2007)
- Wang N, "Patients of myelodysplastic syndrome with mild", moderate myelofibrosis and a monosomal karyotype are independently associated with an adverse prognosis : long-term follow-up data, 2020, pp.12, 5881~5891
