Inflammatory bowel disease in Korea: epidemiology and pathophysiology
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초록
Inflammatory bowel disease (IBD) refers to a group of disorders, including Crohn’s disease and ulcerative colitis, that exhibit similar but distinct manifestations. These diseases are characterized by refractory and chronic inflammation of the bowel. IBD is usually accompanied by severe symptoms. When a patient presents with suspected IBD, physicians encounter various challenges in terms of diagnosis and treatment. In addition, given such characteristics, the associated medical expenses gradually increase. Although IBD was formerly known as a disease of Western countries, the incidence and prevalence are increasing in Korea. Korean investigators have accumulated a great deal of knowledge about the regional characteristics and epidemiology of the disease, especially via well-organized, joint cohort studies. Against this background, this article describes the epidemiology of IBD in Korea compared to that in the West. In addition, an overview of the pathophysiology of the disease is provided, focusing on the latest results.
Abstract
Inflammatory bowel disease (IBD) refers to a group of disorders, including Crohn’s disease and ulcerative colitis, that exhibit similar but distinct manifestations. These diseases are characterized by refractory and chronic inflammation of the bowel. IBD is usually accompanied by severe symptoms. When a patient presents with suspected IBD, physicians encounter various challenges in terms of diagnosis and treatment. In addition, given such characteristics, the associated medical expenses gradually increase. Although IBD was formerly known as a disease of Western countries, the incidence and prevalence are increasing in Korea. Korean investigators have accumulated a great deal of knowledge about the regional characteristics and epidemiology of the disease, especially via well-organized, joint cohort studies. Against this background, this article describes the epidemiology of IBD in Korea compared to that in the West. In addition, an overview of the pathophysiology of the disease is provided, focusing on the latest results.
참고문헌 (84)
- Jong Pil Im, "Changing treatment paradigms for the management of inflammatory bowel disease", The Korean Journal of Internal Medicine, 33(1), pp.28~35 (2018), 대한내과학회[DOI]
- Hyo Sun Lee, "Novel treatments for inflammatory bowel disease", The Korean Journal of Internal Medicine, 33(1), pp.20~27 (2018), 대한내과학회[DOI]
- Jooyoung Lee, "Changes in Direct Healthcare Costs before and after the Diagnosis of Inflammatory Bowel Disease: A Nationwide Population-Based Study", Gut and Liver, 14(1), pp.89~99 (2020), 거트앤리버 소화기연관학회협의회
- Kim JW, "Trends in health-care costs and utilization for inflammatory bowel disease from 2010 to 2014 in Korea : a nationwide population-based study", J Gastroenterol Hepatol, 33, pp.847~854 (2018)
- Hsu-Heng Yen, "Epidemiological trend in inflammatory bowel disease in Taiwan from 2001 to 2015: a nationwide population-based study", Intestinal research, 17(1), pp.54~62 (2019), 대한장연구학회[DOI]
- Park SH, "A 30-year trend analysis in the epidemiology of inflammatory bowel disease in the Songpa-Kangdong district of Seoul, Korea in 1986-2015", J Crohns Colitis, 13, pp.1410~1417 (2019)
- Cha JM, "Long-term prognosis of ulcerative colitis and its temporal changes between 1986 and 2015 in a population-based cohort in the Songpa-Kangdong district of Seoul, Korea", Gut, 69, pp.1432~1440 (2020)
- 천재희, "Crohn’s Disease Clinical Network and Cohort (CONNECT) Study: The First Step Toward Nationwide Multicenter Research of Crohn’s Disease in Korea", Intestinal research, 12(3), pp.173~175 (2014), 대한장연구학회
- Jung Won Lee, "Inflammatory Bowel Disease Cohort Studies in Korea: Present and Future", Intestinal research, 13(3), pp.213~218 (2015), 대한장연구학회
- Moon CM, "Clinical factors and disease course related to diagnostic delay in Korean Crohn’s disease patients : results from the CONNECT Study", PLoS One, 10, pp.e0144390~ (2015)
- Ye Byong Duk, "Changes in the Long-term Prognosis of Crohn’s Disease between 1986 and 2015: The Population-Based Songpa-Kangdong Inflammatory Bowel Disease Cohort Study", Gut and Liver, 16(2), pp.216~227 (2022), 거트앤리버 소화기연관학회협의회[DOI]
- Yoon JY, "Early course of newly diagnosed moderate-to-severe ulcerative colitis in Korea : results from a hospital-based inception cohort study(MOSAIK)", J Gastroenterol Hepatol, 36, pp.2149~2156 (2021)
- 윤준식, "Quality of information on the Internet for Korean patients with inflammatory bowel disease", The Korean Journal of Internal Medicine, 34(6), pp.1215~1222 (2019), 대한내과학회[DOI]
- 박지혜, "Improving the care of inflammatory bowel disease (IBD) patients: perspectives and strategies for IBD center management", The Korean Journal of Internal Medicine, 36(5), pp.1040~1048 (2021), 대한내과학회[DOI]
- 홍승욱, "The first step to unveil the epidemiology of inflammatory bowel disease in Central Asia", Intestinal research, 18(4), pp.345~346 (2020), 대한장연구학회[DOI]
- 송은미, "Natural history of inflammatory bowel disease: a comparison between the East and the West", Intestinal research, 20(4), pp.418~430 (2022), 대한장연구학회[DOI]
- Kaplan GG, "The four epidemiological stages in the global evolution of inflammatory bowel disease", Nat Rev Gastroenterol Hepatol, 18, pp.56~66 (2021)
- Satimai Aniwan, "Temporal trend in the natural history of ulcerative colitis in a country with a low incidence of ulcerative colitis from 2000 through 2018", Intestinal research, 19(2), pp.186~193 (2021), 대한장연구학회[DOI]
- Jamilya Kaibullayeva, "Prevalence and patient awareness of inflammatory bowel disease in Kazakhstan: a cross-sectional study", Intestinal research, 18(4), pp.430~437 (2020), 대한장연구학회[DOI]
- Ajit Sood, "Colitis and Crohn’s Foundation (India): a first nationwide inflammatory bowel disease registry", Intestinal research, 19(2), pp.206~216 (2021), 대한장연구학회[DOI]
- Kwak MS, "Emerging trends of inflammatory bowel disease in South Korea : a nationwide population-based study", J Gastroenterol Hepatol, 34, pp.1018~1026 (2019)
- "2020Inflammatory bowel disease fact sheet in Korea" (2020)[URL]
- Lee CK, "Nationwide validation study of diagnostic algorithms for inflammatory bowel disease in Korean National Health Insurance Service database", J Gastroenterol Hepatol, 35, pp.760~768 (2020)
- Shah SC, "Sex-based differences in incidence of inflammatory bowel diseases : pooled analysis of population-based studies from Western countries", Gastroenterology, 155, pp.1079~1089 (2018)
- Jeongseok Kim, "Successful transition from pediatric to adult care in inflammatory bowel disease: what is the key?", Intestinal research, 17(1), pp.24~35 (2019), 대한장연구학회[DOI]
- Banerjee Rupa, "Very early onset inflammatory bowel disease in a South Asian country where inflammatory bowel disease is emerging: a distinct clinical phenotype from later onset disease", Intestinal research, 19(4), pp.398~407 (2021), 대한장연구학회[DOI]
- Park SH, "Clinical features and long-term outcomes of paediatric-onset inflammatory bowel disease in a population-based cohort in the Songpa-Kangdong district of Seoul, Korea", J Crohns Colitis, 16, pp.207~215 (2022)
- Singh S, "Management of inflammatory bowel diseases in special populations : obese, old, or obstetric", Clin Gastroenterol Hepatol, 18, pp.1367~1380 (2020)
- Shi HY, "Natural history of elderly-onset ulcerative colitis : results from a Territory-wide Inflammatory Bowel Disease Registry", J Crohns Colitis, 10, pp.176~185 (2016)
- Park Sang Hyoung, "Clinical Characteristics and Long-term Prognosis of Elderly-Onset Ulcerative Colitis in a Population-Based Cohort in the Songpa- Kangdong District of Seoul, Korea", Gut and Liver, 15(5), pp.742~751 (2021), 거트앤리버 소화기연관학회협의회[DOI]
- Song EM, "Clinical characteristics and long-term prognosis of elderly onset ulcerative colitis", J Gastroenterol Hepatol, 33, pp.172~179 (2018)
- Hwang SW, "Influence of a positive family history on the clinical course of inflammatory bowel disease", J Crohns Colitis, 10, pp.1024~1032 (2016)
- Jung YS, "Long-term clinical outcomes of urban versus rural environment in Korean patients with Crohn’s disease : results from the CONNECT study", J Crohns Colitis, 9, pp.246~251 (2015)
- Choe JY, "Incidence and prevalence trends of pediatric inflammatory bowel disease in the Daegu-Kyungpook province from 2017 to 2020", Front Pediatr, 9, pp.810173~ (2022)
- 이은지, "Clinical features of Crohn’s disease in Korean patients residing in Busan and Gyeongnam", Intestinal research, 14(1), pp.30~36 (2016), 대한장연구학회
- Han M, "Regional variations in the use of biologics and immunomodulators among Korean patients with inflammatory bowel diseases", J Gastroenterol Hepatol, 34, pp.1166~1174 (2019)
- Julajak Limsrivilai, "Intestinal tuberculosis or Crohn’s disease: a review of the diagnostic models designed to differentiate between these two gastrointestinal diseases", Intestinal research, 19(1), pp.21~32 (2021), 대한장연구학회[DOI]
- Ho-Su Lee, "Change in the diagnosis of inflammatory bowel disease: a hospital-based cohort study from Korea", Intestinal research, 14(3), pp.258~263 (2016), 대한장연구학회
- Rupa Banerjee, "Biologics for the Management of Inflammatory Bowel Disease: A Review in Tuberculosis-Endemic Countries", Gut and Liver, 14(6), pp.685~698 (2020), 거트앤리버 소화기연관학회협의회[DOI]
- Hee Seung Hong, "Seroprevalence of viral infectious diseases and associated factors in Korean patients with inflammatory bowel diseases", The Korean Journal of Internal Medicine, 37(1), pp.73~84 (2022), 대한내과학회[DOI]
- Park SH, "Clinical courses of chronic hepatitis B virus infection and inflammatory bowel disease in patients with both diseases", Inflamm Bowel Dis, 18, pp.2004~2010 (2012)
- Soo-Kyung Park, "Prevention and management of viral hepatitis in inflammatory bowel disease: a clinical practice guideline by the Korean Association for the Study of Intestinal Diseases", Intestinal research, 18(1), pp.18~33 (2020), 대한장연구학회
- Lee HS, "Risk factors and clinical outcomes associated with cytomegalovirus colitis in patients with acute severe ulcerative colitis", Inflamm Bowel Dis, 22, pp.912~918 (2016)
- Park SH, "Severe disease activity and cytomegalovirus colitis are predictive of a nonresponse to infliximab in patients with ulcerative colitis", Dig Dis Sci, 58, pp.3592~3599 (2013)
- Tsai L, "Epidemiology and natural history of perianal Crohn’s disease : a systematic review and meta-analysis of population-based cohorts", Inflamm Bowel Dis (2021)[DOI]
- Jaeyoung Chun, "Association of Perianal Fistulas with Clinical Features and Prognosis of Crohn’s Disease in Korea: Results from the CONNECT Study", Gut and Liver, 12(5), pp.544~554 (2018), 거트앤리버 소화기연관학회협의회
- Ye BD, "Clinical features and long-term prognosis of Crohn’s disease in Korea", Scand J Gastroenterol, 45, pp.1178~1185 (2010)
- Jin Young Yoon, "Effects of Perianal Involvement on Clinical Outcomes in Crohn’s Disease over 10 Years", Gut and Liver, 12(3), pp.297~305 (2018), 거트앤리버 소화기연관학회협의회
- 김정민, "Pathogenesis and clinical perspectives of extraintestinal manifestations in inflammatory bowel diseases", Intestinal research, 18(3), pp.249~264 (2020), 대한장연구학회[DOI]
- 하유정, "Subclinical sacroiliitis detected by abdominopelvic computed tomography in Korean patients with Crohn’s disease", The Korean Journal of Internal Medicine, 36(4), pp.868~877 (2021), 대한내과학회[DOI]
- Yang BR, "Prevalence of extraintestinal manifestations in Korean inflammatory bowel disease patients", PLoS One, 13, pp.e0200363~ (2018)
- Graham DB, "Pathway paradigms revealed from the genetics of inflammatory bowel disease", Nature, 578, pp.527~539 (2020)
- Chen CJ, "Pathophysiology of inflammatory bowel diseases", N Engl J Med, 384, pp.1376~1377 (2021)
- Mitsialis V, "Single-cell analyses of colon and blood reveal distinct immune cell signatures of ulcerative colitis and Crohn’s disease", Gastroenterology, 159, pp.591~608 (2020)
- Hong SN, "Deep resequencing of 131Crohn’s disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants", Gut, 65, pp.788~796 (2016)
- Cadwell K, "Virus-plus-susceptibility gene interaction determines Crohn’s disease gene Atg16L1phenotypes in intestine", Cell, 141, pp.1135~1145 (2010)
- Liu JZ, "Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations", Nat Genet, 47, pp.979~986 (2015)
- Weiser M, "Molecular classification of Crohn’s disease reveals two clinically relevant subtypes", Gut, 67, pp.36~42 (2018)
- Steven Nicolaides, "The impact of tobacco smoking on treatment choice and efficacy in inflammatory bowel disease", Intestinal research, 19(2), pp.158~170 (2021), 대한장연구학회[DOI]
- Ng SC, "Environmental risk factors in inflammatory bowel disease : a population-based case-control study in Asia-Pacific", Gut, 64, pp.1063~1071 (2015)
- Piovani D, "Environmental risk factors for inflammatory bowel diseases : an umbrella review of meta-analyses", Gastroenterology, 157, pp.647~659 (2019)
- Roncoroni L, "Nutrition in patients with inflammatory bowel diseases : a narrative review", Nutrients, 14, pp.751~ (2022)
- Levine A, "Evolving role of diet in the pathogenesis and treatment of inflammatory bowel diseases", Gut, 67, pp.1726~1738 (2018)
- Nor Hamizah Shafiee, "Anti-inflammatory diet and inflammatory bowel disease: what clinicians and patients should know?", Intestinal research, 19(2), pp.171~185 (2021), 대한장연구학회[DOI]
- Emiko Mizoguchi, "Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models", Intestinal research, 18(2), pp.151~167 (2020), 대한장연구학회[DOI]
- Read E, "The role of oral bacteria in inflammatory bowel disease", Nat Rev Gastroenterol Hepatol, 18, pp.731~742 (2021)
- Leiper K, "Randomised placebo-controlled trial of rituximab(anti-CD20)in active ulcerative colitis", Gut, 60, pp.1520~1526 (2011)
- Park SC, "Anti-integrin therapy for inflammatory bowel disease", World J Gastroenterol, 24, pp.1868~1880 (2018)
- Konstantinos H. Katsanos, "Inflammatory Bowel Disease: Updates on Molecular Targets for Biologics", Gut and Liver, 11(4), pp.455~463 (2017), 거트앤리버 소화기연관학회협의회
- Neurath MF, "Current and emerging therapeutic targets for IBD", Nat Rev Gastroenterol Hepatol, 14, pp.269~278 (2017)
- Salas A, "JAK-STAT pathway targeting for the treatment of inflammatory bowel disease", Nat Rev Gastroenterol Hepatol, 17, pp.323~337 (2020)
- Seung-Joo Nam, "T-cell immune response against cytomegalovirus in peripheral blood and colonic mucosa from ulcerative colitis and Crohn’s disease patients", Intestinal research, 16(1), pp.160~162 (2018), 대한장연구학회
- Chang JT, "Molecular regulation of effector and memory T cell differentiation", Nat Immunol, 15, pp.1104~1115 (2014)
- Ritika Rampal, "Prospective validation of CD4+CD25+FOXP3+ T-regulatory cells as an immunological marker to differentiate intestinal tuberculosis from Crohn’s disease", Intestinal research, 19(2), pp.232~238 (2021), 대한장연구학회[DOI]
- Gaffen SL, "The IL-23-IL-17 immune axis : from mechanisms to therapeutic testing", Nat Rev Immunol, 14, pp.585~600 (2014)
- Lee JW, "Novel histone deacetylase 6inhibitor CKD-506 inhibits NF-κB signaling in intestinal epithelial cells and macrophages and ameliorates acute and chronic murine colitis", Inflamm Bowel Dis, 26, pp.852~862 (2020)
- Caruso R, "Host-microbiota interactions in inflammatory bowel disease", Nat Rev Immunol, 20, pp.411~426 (2020)
- Iliev ID, "Effects of intestinal fungi and viruses on immune responses and inflammatory bowel diseases", Gastroenterology, 160, pp.1050~1066 (2021)
- 박찬혁, "Intestinal microbiota, chronic inflammation, and colorectal cancer", Intestinal research, 16(3), pp.338~345 (2018), 대한장연구학회
- Park SK, "Differentially abundant bacterial taxa associated with prognostic variables of Crohn’s disease : results from the IMPACT Study", J Clin Med, 9, pp.1748~ (2020)
- Kostic AD, "The microbiome in inflammatory bowel disease : current status and the future ahead", Gastroenterology, 146, pp.1489~1499 (2014)
- Stephanie J King, "Epithelial-microbial diplomacy: escalating border tensions drive inflammation in inflammatory bowel disease", Intestinal research, 17(2), pp.177~191 (2019), 대한장연구학회[DOI]
- Schirmer M, "Microbial genes and pathways in inflammatory bowel disease", Nat Rev Microbiol, 17, pp.497~511 (2019)
- Mishima Y, "Manipulating resident microbiota to enhance regulatory immune function to treat inflammatory bowel diseases", J Gastroenterol, 55, pp.4~14 (2020)
