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한국인에서 궤양성 대장염은 증가하는가?

Trends in the incidence of ulcerative colitis in Korea

양동훈|양석균
대한내과학회 (The Korean Association Of Internal Medicine)|2009.06|대한내과학회지 (The Korean Journal of Medicine)|제76권 제6호|pp. 637-642

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참고문헌

키워드

Ulcerative colitis; Incidence; Korea궤양성 대장염; 발병률
주제분류내과학

초록

궤양성 대장염은 대장을 침범하는 만성 염증성 장질환으로 1980년대 이전까지는 국내에서는 매우 드문 질환으로 인식되었으나, 최근 20년간의 보고에 따르면 그 발병률이 급격히 증가하고 있음이 확인되었으며, 현재에는 소화기 분야를 전공하는 의사가 임상에서 드물지 않게 접할 수 있다. 한국의 궤양성 대장염의 진단 시 중간 연령은 35세 정도이며, 남녀 비는 과거 여자에서 조금 더 흔한 것으로 보고되었으나, 최근의 인구 기반 연구에서는 남녀 간의 발병률의 차이는 없는 것으로 보고되었다. 국내 궤양성 대장염 환자에서의 염증성 장질환 가족력은 1.6~2.7%로 서양에 비해 낮은 편이나, 가족력에 따른 염증성 장질환의 발병 위험도는 서양과 비슷한 수준이다. 한국의 궤양성 대장염의 발병률은 서양의 경우와 비교하면 여전히 낮은 편이지만, 발병률이 지속적인 증가 추세를 보이고 있으며 질환의 임상 경과가 만성적이면서 환자의 평균 수명이 정상인과 차이가 없어 향후 국내 궤양성 대장염 환자 수는 가파르게 증가할 것으로 판단된다.

Abstract

Ulcerative colitis is an idiopathic chronic inflammatory disease of the colon that has traditionally been considered rare in Korea. The incidence of ulcerative colitis, however, has increased recently. According to the latest population-based epidemiologic study in Korea, the annual incidence rate of ulcerative colitis has increased from 0.22/100,000 inhabitants in 1886 to 3.62/100,000 inhabitants in 2005. The median age at diagnosis of ulcerative colitis is 35 years and the age-adjusted incidence rate does not differ by sex. Although the incidence of ulcerative colitis is still low in Korea compared to Western countries, it has been increasing rapidly for the past two decades. Moreover, patients with ulcerative colitis usually require lifelong medical management and their life expectancy is similar to that of the general population. Therefore, it is expected that the prevalence of ulcerative colitis in Korea will rise remarkably.

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