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What Are the Different Phenotypes of Inflammatory Bowel Disease in Asia?

윤진영|차재명|Park Su Bee
거트앤리버 소화기연관학회협의회|2022.09|Gut and Liver|제16권 제5호|pp. 676-685|DOI 10.5009/gnl210385

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키워드

Ulcerative colitisPhenotypeAsiaInflammatory bowel diseaseCrohn disease

초록

The burden of inflammatory bowel disease (IBD) in Asia has been increasing over the past decades. Although patients with IBD show heterogenous phenotypes depending on the individual characteristics, no significant differences have been established in the IBD phenotypes of Western and Asian populations. However, despite the much lower incidence of IBD in Asia than in Western countries, the incidence has been rapidly increasing in Asia while remaining stable in Western countries. The incidence of ulcerative colitis (UC) showed an earlier and a more marked increase than the incidence of Crohn disease (CD), but the UC-to-CD ratio has recently decreased because of a relative increase in the incidence of CD in Asia. While CD shows a significant male predominance, UC only shows a slight male predominance. A recent study reported that the incidence of IBD in Asia showed a bimodal age distribution with increasing IBD prevalence, similar to the findings of Western studies. CD in Asian patients, especially those in East Asia, is characterized by ileocolonic involvement and perianal fistula. The frequency of extraintestinal manifestations, including primary sclerosing cholangitis, appears to be lower in Asia, but this finding should be interpreted with caution due to the transient and nonspecific nature of these manifestations. Although familial aggregation is lower in East Asia, it may also be explained by the low prevalence of IBD in Asia. Thus, more studies should focus on the differences in phenotypes in Asian IBD patients versus Western patients.

Abstract

The burden of inflammatory bowel disease (IBD) in Asia has been increasing over the past decades. Although patients with IBD show heterogenous phenotypes depending on the individual characteristics, no significant differences have been established in the IBD phenotypes of Western and Asian populations. However, despite the much lower incidence of IBD in Asia than in Western countries, the incidence has been rapidly increasing in Asia while remaining stable in Western countries. The incidence of ulcerative colitis (UC) showed an earlier and a more marked increase than the incidence of Crohn disease (CD), but the UC-to-CD ratio has recently decreased because of a relative increase in the incidence of CD in Asia. While CD shows a significant male predominance, UC only shows a slight male predominance. A recent study reported that the incidence of IBD in Asia showed a bimodal age distribution with increasing IBD prevalence, similar to the findings of Western studies. CD in Asian patients, especially those in East Asia, is characterized by ileocolonic involvement and perianal fistula. The frequency of extraintestinal manifestations, including primary sclerosing cholangitis, appears to be lower in Asia, but this finding should be interpreted with caution due to the transient and nonspecific nature of these manifestations. Although familial aggregation is lower in East Asia, it may also be explained by the low prevalence of IBD in Asia. Thus, more studies should focus on the differences in phenotypes in Asian IBD patients versus Western patients.

참고문헌 (92)

  1. Kaplan GG, "The four epidemiological stages in the global evolution of inflammatory bowel disease", Nat Rev Gastroenterol Hepatol, 18, pp.56~66 (2021)
  2. Molodecky NA, "Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review", Gastroenterology, 142, pp.46~54 (2012)
  3. Kaplan GG, "The global burden of IBD : from 2015 to 2025", Nat Rev Gastroenterol Hepatol, 12, pp.720~727 (2015)
  4. Ng SC, "Incidence and phenotype of inflammatory bowel disease based on results from the Asia-Pacific Crohn's and Colitis Epidemiology Study", Gastroenterology, 145, pp.158~165 (2013)
  5. Ng SC, "Population density and risk of inflammatory bowel disease : a prospective population-based study in 13 countries or regions in Asia-pacific", Am J Gastroenterol, 114, pp.107~115 (2019)
  6. Park SH, "A 30-year trend analysis in the epidemiology of inflammatory bowel disease in the Songpa-Kangdong District of Seoul, Korea in 1986-2015", J Crohns Colitis, 13, pp.1410~1417 (2019)
  7. Zhao J, "First prospective, populationbased inflammatory bowel disease incidence study in mainland of China : the emergence of"western"disease", Inflamm Bowel Dis, 19, pp.1839~1845 (2013)
  8. Zeng Z, "Incidence and clinical characteristics of inflammatory bowel disease in a developed region of Guangdong Province, China : a prospective populationbased study", J Gastroenterol Hepatol, 28, pp.1148~1153 (2013)
  9. Jiang XL, "An analysis of 10218 ulcerative colitis cases in China", World J Gastroenterol, 8, pp.158~161 (2002)
  10. Wei SC, "A nationwide populationbased study of the inflammatory bowel diseases between 1998 and 2008 in Taiwan", BMC Gastroenterol, 13, pp.166~ (2013)
  11. Chuang CH, "Increasing incidence and lifetime risk of inflammatory bowel disease in Taiwan : a nationwide study in a low-endemic area 1998-2010", Inflamm Bowel Dis, 19, pp.2815~2819 (2013)
  12. Hsu-Heng Yen, "Epidemiological trend in inflammatory bowel disease in Taiwan from 2001 to 2015: a nationwide population-based study", Intestinal research, 17(1), pp.54~62 (2019), 대한장연구학회[DOI]
  13. Abdul-Baki H, "Clinical epidemiology of inflammatory bowel disease in Lebanon", Inflamm Bowel Dis, 13, pp.475~480 (2007)
  14. Al-Shamali MA, "Ulcerative colitis in Kuwait : a review of 90 cases", Digestion, 67, pp.218~224 (2003)
  15. Niv Y, "Epidemiology of ulcerative colitis in Israel : a survey of Israeli kibbutz settlements", Am J Gastroenterol, 95, pp.693~698 (2000)
  16. Murakami Y, "Estimated prevalence of ulcerative colitis and Crohn's disease in Japan in 2014 : an analysis of a nationwide survey", J Gastroenterol, 54, pp.1070~1077 (2019)
  17. Jamilya Kaibullayeva, "Prevalence and patient awareness of inflammatory bowel disease in Kazakhstan: a cross-sectional study", Intestinal research, 18(4), pp.430~437 (2020), 대한장연구학회[DOI]
  18. Tezel A, "Epidemiological features of ulcerative colitis in Trakya, Turkey", J Int Med Res, 31, pp.141~148 (2003)
  19. Yang SK, "Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986-2005 : a KASID study", Inflamm Bowel Dis, 14, pp.542~549 (2008)
  20. Thia KT, "An update on the epidemiology of inflammatory bowel disease in Asia", Am J Gastroenterol, 103, pp.3167~3182 (2008)
  21. Thia KT, "Crohn's disease runs a more aggressive course in young Asian patients", Inflamm Bowel Dis, 12, pp.57~61 (2006)
  22. Lok KH, "Epidemiology and clinical characteristics of ulcerative colitis in Chinese population : experience from a single center in Hong Kong", J Gastroenterol Hepatol, 23, pp.406~410 (2008)
  23. Kaplan GG, "Understanding and preventing the global increase of inflammatory bowel disease", Gastroenterology, 152, pp.313~321 (2017)
  24. Ng SC, "Environmental risk factors in inflammatory bowel disease : a population-based casecontrol study in Asia-Pacific", Gut, 64, pp.1063~1071 (2015)
  25. Xu L, "Systematic review with meta-analysis : breastfeeding and the risk of Crohn's disease and ulcerative colitis", Aliment Pharmacol Ther, 46, pp.780~789 (2017)
  26. Wang Q, "Association between physical activity and inflammatory bowel disease risk : a meta-analysis", Dig Liver Dis, 48, pp.1425~1431 (2016)
  27. Wee Khoon Ng, "Changing epidemiological trends of inflammatory bowel disease in Asia", Intestinal research, 14(2), pp.111~119 (2016), 대한장연구학회
  28. Kondo K, "The association between environmental factors and the development of Crohn's disease with focusing on passive smoking : a multicenter case-control study in Japan", PLoS One, 14, pp.e0216429~ (2019)
  29. 장재영, "염증성 장질환에서 위험인자로서 흡연의 역할: 단일기관 연구", 대한소화기학회지, 47(3), pp.198~204 (2006), 대한소화기학회
  30. Naganuma M, "Appendectomy protects against the development of ulcerative colitis and reduces its recurrence : results of a multicenter case-controlled study in Japan", Am J Gastroenterol, 96, pp.1123~1126 (2001)
  31. Jiang L, "Risk factors for ulcerative colitis in a Chinese population : an age-matched and sex-matched casecontrol study", J Clin Gastroenterol, 41, pp.280~284 (2007)
  32. Firouzi F, "Appendectomy, tonsillectomy, and risk of inflammatory bowel disease : a case control study in Iran", Int J Colorectal Dis, 21, pp.155~159 (2006)
  33. Mak WY, "The epidemiology of inflammatory bowel disease : East meets West", J Gastroenterol Hepatol, 35, pp.380~389 (2020)
  34. Hou JK, "Dietary intake and risk of developing inflammatory bowel disease : a systematic review of the literature", Am J Gastroenterol, 106, pp.563~573 (2011)
  35. Shoda R, "Epidemiologic analysis of Crohn disease in Japan : increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan", Am J Clin Nutr, 63, pp.741~745 (1996)
  36. Sakamoto N, "Dietary risk factors for inflammatory bowel disease : a multicenter case-control study in Japan", Inflamm Bowel Dis, 11, pp.154~163 (2005)
  37. Rupa Banerjee, "Familial aggregation of inflammatory bowel disease in India: prevalence, risks and impact on disease behavior", Intestinal research, 17(4), pp.486~495 (2019), 대한장연구학회[DOI]
  38. Masoud M Malekzadeh, "Iranian Registry of Crohn’s and Colitis: study profile of first nation-wide inflammatory bowel disease registry in Middle East", Intestinal research, 17(3), pp.330~339 (2019), 대한장연구학회[DOI]
  39. Ajit Sood, "Colitis and Crohn’s Foundation (India): a first nationwide inflammatory bowel disease registry", Intestinal research, 19(2), pp.206~216 (2021), 대한장연구학회[DOI]
  40. Kedia S, "Epidemiology of inflammatory bowel disease in India : the great shift East", Inflamm Intest Dis, 2, pp.102~115 (2017)
  41. Shah SC, "Sex-based differences in the incidence of inflammatory bowel diseases-pooled analysis of population-based studies from the Asia-Pacific region", Aliment Pharmacol Ther, 49, pp.904~911 (2019)
  42. Morita N, "Incidence and prevalence of inflammatory bowel disease in Japan: nationwide epidemiological survey during the year 1991", J Gastroenterol, 30(Suppl 8), pp.1~4 (1995)
  43. Leong RW, "The epidemiology and phenotype of Crohn's disease in the Chinese population", Inflamm Bowel Dis, 10, pp.646~651 (2004)
  44. Jiang L, "Retrospective survey of 452 patients with inflammatory bowel disease in Wuhan city, central China", Inflamm Bowel Dis, 12, pp.212~217 (2006)
  45. Shah SC, "Sex-based differences in incidence of inflammatory bowel diseases-pooled analysis of population-based studies from western countries", Gastroenterology, 155, pp.1079~1089 (2018)
  46. Yang SK, "How does the epidemiology of inflammatory bowel disease differ between East and West? A Korean perspective", Inflamm Intest Dis, 2, pp.95~101 (2017)
  47. Benchimol EI, "Changing age demographics of inflammatory bowel disease in Ontario, Canada : a population-based cohort study of epidemiology trends", Inflamm Bowel Dis, 20, pp.1761~1769 (2014)
  48. Lapidus A, "Incidence of Crohn's disease in Stockholm County 1955-1989", Gut, 41, pp.480~486 (1997)
  49. Jeuring SF, "Epidemiology and long-term outcome of inflammatory bowel disease diagnosed at elderly age-an increasing distinct entity", Inflamm Bowel Dis, 22, pp.1425~1434 (2016)
  50. Sood A, "Incidence and prevalence of ulcerative colitis in Punjab, North India", Gut, 52, pp.1587~1590 (2003)
  51. Takahashi H, "Second peak in the distribution of age at onset of ulcerative colitis in relation to smoking cessation", J Gastroenterol Hepatol, 29, pp.1603~1608 (2014)
  52. Ekbom A, "The epidemiology of inflammatory bowel disease : a large, population-based study in Sweden", Gastroenterology, 100, pp.350~358 (1991)
  53. Loftus CG, "Update on the incidence and prevalence of Crohn's disease and ulcerative colitis in Olmsted County, Minnesota, 1940-2000", Inflamm Bowel Dis, 13, pp.254~261 (2007)
  54. Vind I, "Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003-2005 : a population-based study from the Danish Crohn colitis database", Am J Gastroenterol, 101, pp.1274~1282 (2006)
  55. Moum B, "Incidence of ulcerative colitis and indeterminate colitis in four counties of southeastern Norway, 1990-93 : a prospective population-based study. The Inflammatory Bowel South-Eastern Norway(IBSEN)Study Group of Gastroenterologists", Scand J Gastroenterol, 31, pp.362~366 (1996)
  56. Samuel S, "Cumulative incidence and risk factors for hospitalization and surgery in a population-based cohort of ulcerative colitis", Inflamm Bowel Dis, 19, pp.1858~1866 (2013)
  57. Jacobsen BA, "Increase in incidence and prevalence of inflammatory bowel disease in northern Denmark : a population-based study, 1978-2002", Eur J Gastroenterol Hepatol, 18, pp.601~606 (2006)
  58. Satimai Aniwan, "Temporal trend in the natural history of ulcerative colitis in a country with a low incidence of ulcerative colitis from 2000 through 2018", Intestinal research, 19(2), pp.186~193 (2021), 대한장연구학회[DOI]
  59. Chow DK, "Changes in Crohn's disease phenotype over time in the Chinese population : validation of the Montreal classification system", Inflamm Bowel Dis, 14, pp.536~541 (2008)
  60. Oriuchi T, "Clinical course and longterm prognosis of Japanese patients with Crohn's disease : predictive factors, rates of operation, and mortality", J Gastroenterol, 38, pp.942~953 (2003)
  61. Yapp TR, "Crohn's disease incidence in Cardifffrom 1930 : an update for 1991-1995", Eur J Gastroenterol Hepatol, 12, pp.907~911 (2000)
  62. Moum B, "Incidence of Crohn's disease in four counties in southeastern Norway, 1990-93 : a prospective population-based study. The Inflammatory Bowel South-Eastern Norway(IBSEN)Study Group of Gastroenterologists", Scand J Gastroenterol, 31, pp.355~361 (1996)
  63. Sjöberg D, "Incidence and clinical course of Crohn's disease during the first year : results from the IBD Cohort of the Uppsala Region(ICURE)of Sweden 2005-2009", J Crohns Colitis, 8, pp.215~222 (2014)
  64. Lapidus A, "Crohn's disease in Stockholm County during 1990-2001 : an epidemiological update", World J Gastroenterol, 12, pp.75~81 (2006)
  65. Shi HY, "Ethnicity influences phenotype and outcomes in inflammatory bowel disease : a systematic review and meta-analysis of population-based studies", Clin Gastroenterol Hepatol, 16, pp.190~197 (2018)
  66. Annunziata ML, "Upper gastrointestinal involvement of Crohn's disease : a prospective study on the role of upper endoscopy in the diagnostic work-up", Dig Dis Sci, 57, pp.1618~1623 (2012)
  67. Sato Y, "Long-term course of Crohn's disease in Japan : incidence of complications, cumulative rate of initial surgery, and risk factors at diagnosis for initial surgery", J Gastroenterol Hepatol, 30, pp.1713~1719 (2015)
  68. Thia KT, "Risk factors associated with progression to intestinal complications of Crohn's disease in a population-based cohort", Gastroenterology, 139, pp.1147~1155 (2010)
  69. Cosnes J, "Long-term evolution of disease behavior of Crohn's disease", Inflamm Bowel Dis, 8, pp.244~250 (2002)
  70. Charpentier C, "Natural history of elderly-onset inflammatory bowel disease : a populationbased cohort study", Gut, 63, pp.423~432 (2014)
  71. Gupta N, "Incidence of stricturing and penetrating complications of Crohn's disease diagnosed in pediatric patients", Inflamm Bowel Dis, 16, pp.638~644 (2010)
  72. Park SH, "Long-term prognosis of Crohn's disease and its temporal change between 1981 and 2012 : a hospital-based cohort study from Korea", Inflamm Bowel Dis, 20, pp.488~494 (2014)
  73. Jin Young Yoon, "Effects of Perianal Involvement on Clinical Outcomes in Crohn’s Disease over 10 Years", Gut and Liver, 12(3), pp.297~305 (2018), 거트앤리버 소화기연관학회협의회
  74. American Gastroenterological Association Clinical Practice Committee, "American Gastroenterological Association medical position statement : perianal Crohn's disease", Gastroenterology, 125, pp.1503~1507 (2003)
  75. Park SK, "Extraintestinal manifestation of inflammatory bowel disease in Asian patients : a multinational study", Dig Liver Dis, 53, pp.196~201 (2021)
  76. Ng SC, "Early course of inflammatory bowel disease in a population-based inception cohort study from 8 countries in Asia and Australia", Gastroenterology, 150, pp.86~95 (2016)
  77. Vavricka SR, "Extraintestinal manifestations of inflammatory bowel disease", Inflamm Bowel Dis, 21, pp.1982~1992 (2015)
  78. Wang Y, "Ulcerative colitis in China : retrospective analysis of 3100 hospitalized patients", J Gastroenterol Hepatol, 22, pp.1450~1455 (2007)
  79. Ling KL, "Clinical characteristics of ulcerative colitis in Singapore, a multiracial city-state", J Clin Gastroenterol, 35, pp.144~148 (2002)
  80. Monsén U, "Extracolonic diagnoses in ulcerative colitis : an epidemiological study", Am J Gastroenterol, 85, pp.711~716 (1990)
  81. Ye BD, "Clinical characteristics of ulcerative colitis associated with primary sclerosing cholangitis in Korea", Inflamm Bowel Dis, 17, pp.1901~1906 (2011)
  82. Broomé U, "Liver disease in ulcerative colitis : an epidemiological and follow up study in the county of Stockholm", Gut, 35, pp.84~89 (1994)
  83. Heikius B, "Hepatobiliary and coexisting pancreatic duct abnormalities in patients with inflammatory bowel disease", Scand J Gastroenterol, 32, pp.153~161 (1997)
  84. Vavricka SR, "Frequency and risk factors for extraintestinal manifestations in the Swiss inflammatory bowel disease cohort", Am J Gastroenterol, 106, pp.110~119 (2011)
  85. Rasmussen HH, "Hepatobiliary dysfunction and primary sclerosing cholangitis in patients with Crohn's disease", Scand J Gastroenterol, 32, pp.604~610 (1997)
  86. Chung SH, "Similar clinical characteristics of familial and sporadic inflammatory bowel disease in South Korea", World J Gastroenterol, 20, pp.17120~17126 (2014)
  87. Hwang SW, "Influence of a positive family history on the clinical course of inflammatory bowel disease", J Crohns Colitis, 10, pp.1024~1032 (2016)
  88. Park JB, "Familial occurrence of inflammatory bowel disease in Korea", Inflamm Bowel Dis, 12, pp.1146~1151 (2006)
  89. Kuwahara E, "Effects of family history on inflammatory bowel disease characteristics in Japanese patients", J Gastroenterol, 47, pp.961~968 (2012)
  90. Yang H, "Familial empirical risks for inflammatory bowel disease : differences between Jews and non-Jews", Gut, 34, pp.517~524 (1993)
  91. Peeters M, "Familial aggregation in Crohn's disease : increased age-adjusted risk and concordance in clinical characteristics", Gastroenterology, 111, pp.597~603 (1996)
  92. Orholm M, "Familial occurrence of inflammatory bowel disease", N Engl J Med, 324, pp.84~88 (1991)

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