Control of Innate and Adaptive Lymphocytes by the RAR-Retinoic Acid Axis
2
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
Lymphocytes, such as T cells, B cells, and innate lymphoid cells (ILCs), play central roles in regulating immune responses. Retinoic acids (RAs) are vitamin A metabolites, produced and metabolized by certain tissue cells and myeloid cells in a tissue-specific manner. It has been established that RAs induce gut-homing receptors on T cells, B cells, and ILCs. A mounting body of evidence indicates that RAs exert far-reaching effects on functional differentiation and fate of these lymphocytes. For example, RAs promote effector T cell maintenance, generation of induced gut-homing regulatory and effector T cell subsets, antibody production by B cells, and functional maturation of ILCs. Key functions of RAs in regulating major groups of innate and adaptive lymphocytes are highlighted in this article.
Abstract
Lymphocytes, such as T cells, B cells, and innate lymphoid cells (ILCs), play central roles in regulating immune responses. Retinoic acids (RAs) are vitamin A metabolites, produced and metabolized by certain tissue cells and myeloid cells in a tissue-specific manner. It has been established that RAs induce gut-homing receptors on T cells, B cells, and ILCs. A mounting body of evidence indicates that RAs exert far-reaching effects on functional differentiation and fate of these lymphocytes. For example, RAs promote effector T cell maintenance, generation of induced gut-homing regulatory and effector T cell subsets, antibody production by B cells, and functional maturation of ILCs. Key functions of RAs in regulating major groups of innate and adaptive lymphocytes are highlighted in this article.
참고문헌 (93)
- Fan X, "Hallmarks of tissue-resident lymphocytes", Cell, 164, pp.1198~1211 (2016)[DOI]
- Masopust D, "The integration of T cell migration, differentiation and function", Nat Rev Immunol, 13, pp.309~320 (2013)[DOI]
- Carbone FR, "Tissue-resident memory T cells and fixed immune surveillance in nonlymphoid organs", J Immunol, 195, pp.17~22 (2015)[DOI]
- Hardy RR, "Perspectives on fetal derived CD5+ B1 B cells", Eur J Immunol, 45, pp.2978~2984 (2015)[DOI]
- Clark MR, "Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling", Nat Rev Immunol, 14, pp.69~80 (2014)[DOI]
- Walker JA, "Innate lymphoid cells--how did we miss them?", Nat Rev Immunol, 13, pp.75~87 (2013)[DOI]
- Tait Wojno ED, "Emerging concepts and future challenges in innate lymphoid cell biology", J Exp Med, 213, pp.2229~2248 (2016)[DOI]
- Robinette ML, "Immune modules shared by innate lymphoid cells and T cells", J Allergy Clin Immunol, 138, pp.1243~1251 (2016)[DOI]
- Ransom J, "The rhythm of retinoids in the brain", J Neurochem, 129, pp.366~376 (2014)[DOI]
- Raverdeau M, "Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis", Proc Natl Acad Sci U S A, 109, pp.16582~16587 (2012)[DOI]
- Tulachan SS, "All-trans retinoic acid induces differentiation of ducts and endocrine cells by mesenchymal", epithelial interactions in embryonic pancreas, 2003, pp.52, 76~84
- Erkelens MN, "Retinoic acid and immune homeostasis: a balancing act", Trends Immunol, 38, pp.168~180 (2017)[DOI]
- Raverdeau M, "Modulation of T cell and innate immune responses by retinoic acid", J Immunol, 192, pp.2953~2958 (2014)[DOI]
- Kim CH, "Host and microbial factors in regulation of T cells in the intestine", Front Immunol, 4, pp.141~ (2013)
- Hashimoto-Hill S, "Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7", Mucosal Immunol, 10, pp.912~923 (2017)[DOI]
- Cunningham TJ, "Mechanisms of retinoic acid signalling and its roles in organ and limb development", Nat Rev Mol Cell Biol, 16, pp.110~123 (2015)[DOI]
- Vermot J, "Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo", Science, 308, pp.563~566 (2005)[DOI]
- Kawaguchi R, "A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A", Science, 315, pp.820~825 (2007)[DOI]
- Goverse G, "Diet-derived short chain fatty acids stimulate intestinal epithelial cells to induce mucosal tolerogenic dendritic cells", J Immunol, 198, pp.2172~2181 (2017)[DOI]
- Szatmari I, "PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells", J Exp Med, 203, pp.2351~2362 (2006)[DOI]
- Broadhurst MJ, "Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice", PLoS Pathog, 8, pp.e1002883~ (2012)[DOI]
- Hess DA, "Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells", Blood, 107, pp.2162~2169 (2006)[DOI]
- Vicente-Suarez I, "Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells", Mucosal Immunol, 8, pp.141~151 (2015)[DOI]
- Topletz AR, "Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases", Biochem Pharmacol, 83, pp.149~163 (2012)[DOI]
- Yamamoto Y, "Regulation of CYP26 (cytochrome P450RAI) mRNA expression and retinoic acid metabolism by retinoids and dietary vitamin A in liver of mice and rats", FASEB J, 14, pp.2119~2127 (2000)[DOI]
- Moulas AN, "Serum retinoic acid, retinol and retinyl palmitate levels in patients with lung cancer", Respirology, 11, pp.169~174 (2006)[DOI]
- Wang C, "Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine", J Immunol, 184, pp.5519~5526 (2010)[DOI]
- Shaw N, "Retinoic acid is a high affinity selective ligand for the peroxisome proliferator-activated receptor beta", delta, 2003, pp.278, 41589~41592
- Huo L, "All-trans retinoic acid modulates mitogen-activated protein kinase pathway activation in human scleral fibroblasts through retinoic acid receptor beta", Mol Vis, 19, pp.1795~1803 (2013)
- Masia S, "Rapid, nongenomic actions of retinoic acid on phosphatidylinositol-3-kinase signaling pathway mediated by the retinoic acid receptor", Mol Endocrinol, 21, pp.2391~2402 (2007)[DOI]
- Wu H, "Retinoic acid-induced upregulation of miR-219 promotes the differentiation of embryonic stem cells into neural cells", Cell Death Dis, 8, pp.e2953~ (2017)[DOI]
- Kiss I, "Retinoid receptor-activating ligands are produced within the mouse thymus during postnatal development", Eur J Immunol, 38, pp.147~155 (2008)[DOI]
- Szondy Z, "All-trans retinoic acid inhibition of anti-CD3-induced T cell apoptosis in human immunodeficiency virus infection mostly concerns CD4 T lymphocytes and is mediated via regulation of CD95 ligand expression", J Infect Dis, 178, pp.1288~1298 (1998)[DOI]
- Szondy Z, "Inhibition of activation-induced apoptosis of thymocytes by all-trans- and 9-cis-retinoic acid is mediated via retinoic acid receptor alpha", Biochem J, 331, pp.767~774 (1998)[DOI]
- Cantorna MT, "Vitamin A deficiency results in a priming environment conducive for Th1 cell development", Eur J Immunol, 25, pp.1673~1679 (1995)[DOI]
- Hoag KA, "Retinoic acid enhances the T helper 2 cell development that is essential for robust antibody responses through its action on antigen-presenting cells", J Nutr, 132, pp.3736~3739 (2002)[DOI]
- Iwata M, "Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors", Int Immunol, 15, pp.1017~1025 (2003)[DOI]
- Stephensen CB, "Vitamin A deficiency increases the in vivo development of IL-10-positive Th2 cells and decreases development of Th1 cells in mice", J Nutr, 134, pp.2660~2666 (2004)[DOI]
- Kang SG, "High and low vitamin A therapies induce distinct FoxP3+ T-cell subsets and effectively control intestinal inflammation", Gastroenterology, 137, pp.1391~1402 (2009)[DOI]
- Hall JA, "Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha", Immunity, 34, pp.435~447 (2011)[DOI]
- Brown CC, "Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program", Immunity, 42, pp.499~511 (2015)[DOI]
- Coombes JL, "A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism", J Exp Med, 204, pp.1757~1764 (2007)[DOI]
- Elias KM, "Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3", Stat-5 independent signaling pathway, 2008, pp.111, 1013~1020
- Hill JA, "Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells", Immunity, 29, pp.758~770 (2008)[DOI]
- Kang SG, "Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells", J Immunol, 179, pp.3724~3733 (2007)[DOI]
- Urvalek A, "The roles of retinoic acid and retinoic acid receptors in inducing epigenetic changes", Subcell Biochem, 70, pp.129~149 (2014)
- Iwata M, "Retinoic acid imprints gut-homing specificity on T cells", Immunity, 21, pp.527~538 (2004)[DOI]
- Edele F, "Cutting edge: instructive role of peripheral tissue cells in the imprinting of T cell homing receptor patterns", J Immunol, 181, pp.3745~3749 (2008)[DOI]
- Johansson-Lindbom B, "Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant", J Exp Med, 198, pp.963~969 (2003)[DOI]
- Mora JR, "Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells", Nature, 424, pp.88~93 (2003)[DOI]
- Kang SG, "Complementary roles of retinoic acid and TGF-<TEX>${\beta}1$<", TEX> in coordinated expression of mucosal integrins by T cells, 2011, pp.4, 66~82
- Bartlett R, "The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease", Pharmacol Rev, 66, pp.638~675 (2014)[DOI]
- Di Virgilio F, "The P2X7 Receptor in Infection and Inflammation", Immunity, 47, pp.15~31 (2017)[DOI]
- Chen Q, "Retinoic acid regulates CD1d gene expression at the transcriptional level in human and rodent monocytic cells", Exp Biol Med (Maywood), 232, pp.488~494 (2007)
- Allan LL, "CD1d and CD1c expression in human B cells is regulated by activation and retinoic acid receptor signaling", J Immunol, 186, pp.5261~5272 (2011)[DOI]
- Chang HK, "Retinoic acid modulates interferon-<TEX>${\gamma}$<", TEX> production by hepatic natural killer T cells via phosphatase 2A and the extracellular signal-regulated kinase pathway, 2015, pp.35, 200~212
- Lee KA, "Retinoic acid alleviates Con A-induced hepatitis and differentially regulates effector production in NKT cells", Eur J Immunol, 42, pp.1685~1694 (2012)[DOI]
- Mielke LA, "Retinoic acid expression associates with enhanced IL-22 production by <TEX>${\gamma}{\delta}$<", TEX> T cells and innate lymphoid cells and attenuation of intestinal inflammation, 2013, pp.210, 1117~1124
- Buck J, "Retinol is essential for growth of activated human B cells", J Exp Med, 171, pp.1613~1624 (1990)[DOI]
- Chen X, "Retinoids accelerate B lineage lymphoid differentiation", J Immunol, 180, pp.138~145 (2008)[DOI]
- Morikawa K, "All-trans-retinoic acid accelerates the differentiation of human B lymphocytes maturing into plasma cells", Int Immunopharmacol, 5, pp.1830~1838 (2005)[DOI]
- Chen Q, "Retinoic acid promotes mouse splenic B cell surface IgG expression and maturation stimulated by CD40 and IL-4", Cell Immunol, 249, pp.37~45 (2007)[DOI]
- Indrev©¡r RL, "IRF4 is a critical gene in retinoic acid-mediated plasma cell formation and is deregulated in common variable immunodeficiency-derived B cells", J Immunol, 195, pp.2601~2611 (2015)[DOI]
- Chun TY, "Retinoid repletion of vitamin A-deficient mice restores IgG responses", J Nutr, 122, pp.1062~1069 (1992)[DOI]
- DeCicco KL, "All-trans-retinoic acid and polyriboinosinic: polyribocytidylic acid in combination potentiate specific antibody production and cell-mediated immunity", Immunology, 104, pp.341~348 (2001)[DOI]
- Mora JR, "Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells", Science, 314, pp.1157~1160 (2006)[DOI]
- Hammerschmidt SI, "Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice", J Clin Invest, 121, pp.3051~3061 (2011)[DOI]
- Suzuki K, "The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut", Immunity, 33, pp.71~83 (2010)[DOI]
- Watanabe K, "Requirement for Runx proteins in IgA class switching acting downstream of TGF-beta 1 and retinoic acid signaling", J Immunol, 184, pp.2785~2792 (2010)[DOI]
- Scheffel F, "Retinoic acid inhibits CD40 plus IL-4 mediated IgE production through alterations of sCD23, sCD54 and IL-6 production", Inflamm Res, 54, pp.113~118 (2005)[DOI]
- Tokuyama H, "The regulatory effects of all-trans-retinoic acid on isotype switching: retinoic acid induces IgA switch rearrangement in cooperation with IL-5 and inhibits IgG1 switching", Cell Immunol, 192, pp.41~47 (1999)[DOI]
- Eriksen AB, "Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing-remitting multiple sclerosis", J Neuroimmunol, 278, pp.11~18 (2015)[DOI]
- Rudraraju R, "Respiratory tract epithelial cells express retinaldehyde dehydrogenase ALDH1A and enhance IgA production by stimulated B cells in the presence of vitamin A", PLoS One, 9, pp.e86554~ (2014)[DOI]
- Conway KL, "ATG5 regulates plasma cell differentiation", Autophagy, 9, pp.528~537 (2013)[DOI]
- Pengo N, "Plasma cells require autophagy for sustainable immunoglobulin production", Nat Immunol, 14, pp.298~305 (2013)[DOI]
- Eriksen AB, "Retinoic acid-induced IgG production in TLR-activated human primary B cells involves ULK1-mediated autophagy", Autophagy, 11, pp.460~471 (2015)[DOI]
- Pantazi E, "Cutting edge: retinoic acid signaling in B cells is essential for oral immunization and microflora composition", J Immunol, 195, pp.1368~1371 (2015)[DOI]
- Palm NW, "Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease", Cell, 158, pp.1000~1010 (2014)[DOI]
- 강성호, "Lactoferrin Combined with Retinoic Acid Stimulates B1 Cells to Express IgA Isotype and Gut-homing Molecules", Immune Network, 15(1), pp.37~43 (2015), 대한면역학회[DOI]
- Roy B, "An intrinsic propensity of murine peritoneal B1b cells to switch to IgA in presence of TGF-<TEX>${\beta}$<", TEX> and retinoic acid, 2013, pp.8, e82121~
- Marks E, "Retinoic acid signaling in B cells is required for the generation of an effective T-independent immune response", Front Immunol, 7, pp.643~ (2016)
- Guido Heine, "9-cis retinoic acid modulates the type I allergic immune response", Journal of Allergy and Clinical Immunology, 141(2), pp.650~658.e5 (2018), Elsevier BV[DOI]
- Abb J, "Effect of retinoic acid on the spontaneous and interferon-induced activity of human natural killer cells", Int J Cancer, 30, pp.307~310 (1982)[DOI]
- Eremin O, "Inhibition of antibody-dependent cellular cytotoxicity and natural cytotoxicity by retinoic acid", Int Arch Allergy Appl Immunol, 75, pp.2~7 (1984)[DOI]
- Konjevic G, "In vitro increased natural killer cell activity of metastatic melanoma patients with interferon-<TEX>${\alpha}$<", TEX> alone as opposed to its combination with 13-cis retinoic acid is associated with modulation of NKG2D and CD161 activating receptor expression, 2012, pp.17, 761~769
- Li A, "All-trans retinoic acid negatively regulates cytotoxic activities of nature killer cell line 92", Biochem Biophys Res Commun, 352, pp.42~47 (2007)[DOI]
- Sanchez-Martinez D, "All-trans retinoic acid (ATRA) induces miR-23a expression, decreases CTSC expression and granzyme B activity leading to impaired NK cell cytotoxicity", Int J Biochem Cell Biol, 49, pp.42~52 (2014)[DOI]
- Jinushi M, "Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid", Int J Cancer, 104, pp.354~361 (2003)[DOI]
- van de Pavert SA, "Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity", Nature, 508, pp.123~127 (2014)[DOI]
- Goverse G, "Vitamin A controls the presence of <TEX>$ROR{\gamma}+$<", TEX> innate lymphoid cells and lymphoid tissue in the small intestine, 2016, pp.196, 5148~5155
- Kim MH, "Retinoic acid differentially regulates the migration of innate lymphoid cell subsets to the gut", Immunity, 43, pp.107~119 (2015)[DOI]
- Spencer SP, "Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity", Science, 343, pp.432~437 (2014)[DOI]
- Ruiter B, "Vitamins A and D have antagonistic effects on expression of effector cytokines and gut-homing integrin in human innate lymphoid cells", Clin Exp Allergy, 45, pp.1214~1225 (2015)[DOI]
