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Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation

박정호|김명후|김창한
대한면역학회 (The Korean Association of Immunologists)|2014.12|Immune Network|제14권 제6호|pp. 277-288

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키워드

InflammationColitisTh1IL-10MicrobiotaTh17Short-chain fatty acidsFoxP3Microbial metabolites

초록

T cells are central players in the regulation of adaptive immunityand immune tolerance. In the periphery, T cell differentiationfor maturation and effector function is regulated bya number of factors. Various factors such as antigens,co-stimulation signals, and cytokines regulate T cell differentiationinto functionally specialized effector and regulatoryT cells. Other factors such as nutrients, micronutrients, nuclearhormones and microbial products provide important environmentalcues for T cell differentiation. A mounting bodyof evidence indicates that the microbial metabolites shortchainfatty acids (SCFAs) have profound effects on T cellsand directly and indirectly regulate their differentiation. Wereview the current status of our understanding of SCFA functionsin regulation of peripheral T cell activity and discusstheir impact on tissue inflammation.

Abstract

T cells are central players in the regulation of adaptive immunityand immune tolerance. In the periphery, T cell differentiationfor maturation and effector function is regulated bya number of factors. Various factors such as antigens,co-stimulation signals, and cytokines regulate T cell differentiationinto functionally specialized effector and regulatoryT cells. Other factors such as nutrients, micronutrients, nuclearhormones and microbial products provide important environmentalcues for T cell differentiation. A mounting bodyof evidence indicates that the microbial metabolites shortchainfatty acids (SCFAs) have profound effects on T cellsand directly and indirectly regulate their differentiation. Wereview the current status of our understanding of SCFA functionsin regulation of peripheral T cell activity and discusstheir impact on tissue inflammation.

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