본문 바로가기
KERD
논문KCI 등재

Protective effect of dietary chitosan on cadmium accumulation in rats

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

BACKGROUND/OBJECTIVES: Cadmium is a toxic metal that is an occupational and environmental concern especially becauseof its human carcinogenicity; it induces serious adverse effects in various organs and tissues. Even low levels of exposureto cadmium could be harmful owing to its extremely long half-life in the body. Cadmium intoxication may be preventedby the consumption of dietary components that potentially reduce its accumulation in the body. Dietary chitosan is a polysaccharidederived from animal sources; it has been known for its ability to bind to divalent cations including cadmium, in additionto other beneficial effects including hypocholesterolemic and anticancer effects. Therefore, we aimed to investigate the roleof dietary chitosan in reducing cadmium accumulation using an in vivo system. MATERIALS/METHODS: Cadmium was administered orally at 2 mg (three times per week) to three groups of Sprague-Dawleyrats: control, low-dose, and high-dose (0, 3, and 5%, respectively) chitosan diet groups for eight weeks. Cadmium accumulation,as well as tissue functional and histological changes, was determined. RESULTS: Compared to the control group, rats fed the chitosan diet showed significantly lower levels of cadmium in bloodand tissues including the kidneys, liver, and femur. Biochemical analysis of liver function including the determination of aspartateaminotransferase and total bilirubin levels showed that dietary chitosan reduced hepatic tissue damage caused by cadmiumintoxication and prevented the associated bone disorder. CONCLUSIONS: These results suggest that dietary chitosan has the potential to reduce cadmium accumulation in the bodyas well as protect liver function and bone health against cadmium intoxication.

Abstract

BACKGROUND/OBJECTIVES: Cadmium is a toxic metal that is an occupational and environmental concern especially becauseof its human carcinogenicity; it induces serious adverse effects in various organs and tissues. Even low levels of exposureto cadmium could be harmful owing to its extremely long half-life in the body. Cadmium intoxication may be preventedby the consumption of dietary components that potentially reduce its accumulation in the body. Dietary chitosan is a polysaccharidederived from animal sources; it has been known for its ability to bind to divalent cations including cadmium, in additionto other beneficial effects including hypocholesterolemic and anticancer effects. Therefore, we aimed to investigate the roleof dietary chitosan in reducing cadmium accumulation using an in vivo system. MATERIALS/METHODS: Cadmium was administered orally at 2 mg (three times per week) to three groups of Sprague-Dawleyrats: control, low-dose, and high-dose (0, 3, and 5%, respectively) chitosan diet groups for eight weeks. Cadmium accumulation,as well as tissue functional and histological changes, was determined. RESULTS: Compared to the control group, rats fed the chitosan diet showed significantly lower levels of cadmium in bloodand tissues including the kidneys, liver, and femur. Biochemical analysis of liver function including the determination of aspartateaminotransferase and total bilirubin levels showed that dietary chitosan reduced hepatic tissue damage caused by cadmiumintoxication and prevented the associated bone disorder. CONCLUSIONS: These results suggest that dietary chitosan has the potential to reduce cadmium accumulation in the bodyas well as protect liver function and bone health against cadmium intoxication.

참고문헌 (51)

  1. Järup L, "Current status of cadmium as an environmental health problem", Toxicol Appl Pharmacol, 238, pp.201~208 (2009)
  2. Clemens S, "Plant science: the key to preventing slow cadmium poisoning", Trends Plant Sci, 18, pp.92~99 (2013)
  3. European Food Safety Authority, "Cadmium dietary exposure in the European population", EFSA J, 10, pp.2551~ (2012)
  4. Sharma A., "Evaluation of certain food additives and contaminants, Seventy-third report of the Joint FAO", WHO Expert Committee on Food Additives, 2012, pp.135, 446~447
  5. Olsson IM, "Cadmium in blood and urine--impact of sex, age, dietary intake, iron status, and former smoking--association of renal effects", Environ Health Perspect, 110, pp.1185~1190 (2002)
  6. Järup L, "Biological half-time of cadmium in the blood of workers after cessation of exposure", Scand J Work Environ Health, 9, pp.327~331 (1983)
  7. Adams SV, "Cadmium exposure and cancer mortality in the Third National Health and Nutrition Examination Survey cohort", Occup Environ Med, 69, pp.153~156 (2012)
  8. Engström A, "Associations between dietary cadmium exposure and bone mineral density and risk of osteoporosis and fractures among women", Bone, 50, pp.1372~1378 (2012)
  9. Nordberg G, "Kidney dysfunction and cadmium exposure--factors influencing dose-response relationships", J Trace Elem Med Biol, 26, pp.197~200 (2012)
  10. Wu KC, "Nrf2 activation prevents cadmiuminduced acute liver injury", Toxicol Appl Pharmacol, 263, pp.14~20 (2012)
  11. Satarug S, "Cadmium, environmental exposure, and health outcomes", Cien Saude Colet, 16, pp.2587~2602 (2011)
  12. Amamou F, "Protective effect of olive oil and colocynth oil against cadmiuminduced oxidative stress in the liver of Wistar rats", Food Chem Toxicol, 78, pp.177~184 (2015)
  13. Thomas LD, "Early kidney damage in a population exposed to cadmium and other heavy metals", Environ Health Perspect, 117, pp.181~184 (2009)
  14. Noonan CW, "Effects of exposure to low levels of environmental cadmium on renal biomarkers", Environ Health Perspect, 110, pp.151~155 (2002)
  15. de Burbure C, "Renal and neurologic effects of cadmium, lead, mercury, and arsenic in children: evidence of early effects and multiple interactions at environmental exposure levels", Environ Health Perspect, 114, pp.584~590 (2006)
  16. Kobayashi E, "Estimation of benchmark doses as threshold levels of urinary cadmium, based on excretion of β2-microglobulin in cadmium-polluted and non-polluted regions in Japan", Toxicol Lett, 179, pp.108~112 (2008)
  17. Inaba T, "Estimation of cumulative cadmium intake causing Itai-itai disease", Toxicol Lett, 159, pp.192~201 (2005)
  18. Gallagher CM, "Urinary cadmium and osteoporosis in U.S. Women >or= 50 years of age: NHANES 1988-1994and 1999-2004", Environ Health Perspect, 116, pp.1338~1343 (2008)
  19. Schutte R, "Bone resorption and environmental exposure to cadmium in women: a population study", Environ Health Perspect, 116, pp.777~783 (2008)
  20. Yuan G, "Toxicological assessment of combined lead and cadmium: acute and sub-chronic toxicity study in rats", Food Chem Toxicol, 65, pp.260~268 (2014)
  21. Eriksen KT, "Dietary cadmium intake and risk of breast, endometrial and ovarian cancer in Danish postmenopausal women: a prospective cohort study", PLoS One, 9, pp.e100815~ (2014)
  22. Harish Prashanth KV, "Chitin", chitosan: modifications and their unlimited application potential--an overview, 2007, pp.18, 117~131
  23. Samarasinghe RM, "The effect of oral administration of iron saturated-bovine lactoferrin encapsulated chitosan-nanocarriers on osteoarthritis", Biomaterials, 35, pp.7522~7534 (2014)
  24. Zhang J, "Dietary chitosan improves hypercholesterolemia in rats fed high-fat diets", Nutr Res, 28, pp.383~390 (2008)
  25. Yamada S, "Chitosan monomer accelerates alkaline phosphatase activity on human osteoblastic cells under hypofunctional conditions", J Biomed Mater Res A, 83, pp.290~295
  26. Liao FH, "Chitosan supplementation lowers serum lipids and maintains normal calcium, magnesium, and iron status in hyperlipidemic patients", Nutr Res, 27, pp.146~151 (2007)
  27. Qin C, "Enzymic preparation of watersoluble chitosan and their antitumor activity", Int J Biol Macromol, 31, pp.111~117 (2002)
  28. Gallaher DD, "A glucomannan and chitosan fiber supplement decreases plasma cholesterol and increases cholesterol excretion in overweight normocholesterolemic humans", J Am Coll Nutr, 21, pp.428~433 (2002)
  29. Meininger CJ, "Glucosamine inhibits inducible nitric oxide synthesis", Biochem Biophys Res Commun, 279, pp.234~239 (2000)
  30. Shen KT, "Inhibitory effects of chitooligosaccharides on tumor growth and metastasis", Food Chem Toxicol, 47, pp.1864~1871 (2009)
  31. Renault F, "Chitosan for coagulation", flocculation processes-an eco-friendly approach, 2009, pp.45, 1337~1348
  32. Gamage A, "Use of chitosan for the removal of metal ion contaminants and proteins from water", Food Chem, 104, pp.989~996 (2007)
  33. Bravo-Osuna I, "In vitro evaluation of calcium binding capacity of chitosan and thiolated chitosan poly (isobutyl cyanoacrylate) core-shell nanoparticles", Int J Pharm, 338, pp.284~290 (2007)
  34. Lima IS, "Interaction of copper with chitosan and succinic anhydride derivative-a factorial design evaluation of the chemi sorption process", Colloids Surf A Physicochem Eng Asp, 229, pp.129~136 (2003)
  35. Crini G, "Application of chitosan, a natural aminopolysaccharide, for dye removal from aqueous solutions by adsorption processes using batch studies: a review of recent literature", Prog Polym Sci, 33, pp.399~447 (2008)
  36. Waalkes MP., "Cadmium carcinogenesis", Mutat Res, 533, pp.107~120 (2003)
  37. Reeves PG, "AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet", J Nutr, 123, pp.1939~1951 (1993)
  38. Klaassen CD, "Metallothionein: an intracellular protein to protect against cadmium toxicity", Annu Rev Pharmacol Toxicol, 39, pp.267~294 (1999)
  39. Bikle DD., "Biochemical markers in the assessment of bone disease", Am J Med, 103, pp.427~436 (1997)
  40. Nordberg GF, "Handbook on the Toxicology of Metals", pp.446~486 (2007), Academic Press
  41. Leazer TM, "Cadmium absorption and its relationship to divalent metal transporter-1 in the pregnant rat", Toxicol Appl Pharmacol, 185, pp.18~24 (2002)
  42. Alfvén T, "Low-level cadmium exposure and osteoporosis", J Bone Miner Res, 15, pp.1579~1586 (2000)
  43. Staessen JA, "Environmental exposure to cadmium, forearm bone density, and risk of fractures: prospective population study", Lancet, 353, pp.1140~1144 (1999), Public Health and Environmental Exposure to Cadmium (PheeCad) Study Group
  44. Choi JH, "Action of green tea catechin on bone metabolic disorder in chronic cadmiumpoisoned rats", Life Sci, 73, pp.1479~1489 (2003)
  45. Chan EL, "Calcium metabolism and bone calcium content in normal and oophorectomized rats consuming various levels of saline for 12 months", J Nutr, 128, pp.633~639 (1998)
  46. Sims NA, "Parathyroidectomy does not prevent bone loss in the oophorectomized rat", J Bone Miner Res, 9, pp.1859~1863 (1994)
  47. 심지애, "Effect of Chlorella intake on Cadmium metabolism in rats", Nutrition Research and Practice, 3(1), pp.15~22 (2009), 한국영양학회
  48. 김유진, "Effect of Chlorella vulgaris intake on cadmium detoxification in rats fed cadmium", Nutrition Research and Practice, 3(2), pp.89~94 (2009), 한국영양학회
  49. Je JY, "Reactive oxygen species scavenging activity of aminoderivatized chitosan with different degree of deacetylation", Bioorg Med Chem, 14, pp.5989~5994 (2006)
  50. Mendis E, "An in vitro cellular analysis of the radical scavenging efficacy of chitooligosaccharides", Life Sci, 80, pp.2118~2127 (2007)
  51. Seo JW, "Trend of blood lead, mercury, and cadmium levels in Korean population: data analysis of the Korea National Health and Nutrition Examination Survey", Environ Monit Assess, 187, pp.146~ (2015)

관련 논문AI추천

이 간행물의 다른 논문 (14건)