차 음료가 카드뮴 섭취 흰쥐의 카드뮴 축적과 배설에 미치는 영향
Effects of Tea Beverages on Cadmium Accumulation and Excretion in Rats Given Cadmium
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
The effects tea beverages (TBs) prepared from powdered green tea (Gt), oolong tea (Ot), black tea (Bt), or pure tea (Pt) with lemon, orange, grenadine etc on cadmium toxicity in rats were investigated. Sensory evaluations of the TBs are better than those of each water extracted teas. Cadmium (50 ppm) was administered to experimental rats fed a basic diet, or a diet with various TBs (15%, w/v), for 5 weeks. Although body weight gains, feed intakes, and fecal weights in all Cd-treated groups were lower than those in the normal control group (NC), feed efficiency ratio, urine volumes, liver weights, and kidney weights did not differ significantly between groups. The serum ALT and AST levels in the Cd-treated control group (Cd-Co) were higher than those in the NC animals. Serum ALT and AST levels in all Cd-treated rats fed TB-supplemented diets were lower than in animals of the Cd-Co group. Tibia and femur weights in Cd-Co animals were lower than those in NC rats. Tibia and femur weights in Cd-treated rats fed TB-supplemented diets were higher than those in Cd-Co animals. There were no between-group differences in tibia lengths; animals in the NC and TB-supplemented diet groups showed femur lengths longer than those of Cd-Co rats. Although the contents of crude ash and cadmium in the femurs of Cd-Co rats was markedly higher than in the femurs of NC animals, the calcium content in femurs of Cd-Co rats was significantly lower than that in the femurs of NC animals. The changes in mineral levels caused by Cd administration were alleviated by every TB-supplemented diet tested. Whereas fecal calcium excretion by Cd-Co animals was significantly higher than that of NC rats, calcium excretion by Cd-treated rats fed TB-supplemented diets was significantly lower than that of Cd-Co animals. Fecal cadmium excretion by all Cd-treated rats fed TB-supplemented diets was significantly higher than that of Cd-Co animals. In conclusion, this study provides experimental evidence that various TBs may regulate cadmium-induced organ toxicity by reducing cadmium accumulation in tissues through the mechanism of increasing the fecal excretion of cadmium.
Abstract
The effects tea beverages (TBs) prepared from powdered green tea (Gt), oolong tea (Ot), black tea (Bt), or pure tea (Pt) with lemon, orange, grenadine etc on cadmium toxicity in rats were investigated. Sensory evaluations of the TBs are better than those of each water extracted teas. Cadmium (50 ppm) was administered to experimental rats fed a basic diet, or a diet with various TBs (15%, w/v), for 5 weeks. Although body weight gains, feed intakes, and fecal weights in all Cd-treated groups were lower than those in the normal control group (NC), feed efficiency ratio, urine volumes, liver weights, and kidney weights did not differ significantly between groups. The serum ALT and AST levels in the Cd-treated control group (Cd-Co) were higher than those in the NC animals. Serum ALT and AST levels in all Cd-treated rats fed TB-supplemented diets were lower than in animals of the Cd-Co group. Tibia and femur weights in Cd-Co animals were lower than those in NC rats. Tibia and femur weights in Cd-treated rats fed TB-supplemented diets were higher than those in Cd-Co animals. There were no between-group differences in tibia lengths; animals in the NC and TB-supplemented diet groups showed femur lengths longer than those of Cd-Co rats. Although the contents of crude ash and cadmium in the femurs of Cd-Co rats was markedly higher than in the femurs of NC animals, the calcium content in femurs of Cd-Co rats was significantly lower than that in the femurs of NC animals. The changes in mineral levels caused by Cd administration were alleviated by every TB-supplemented diet tested. Whereas fecal calcium excretion by Cd-Co animals was significantly higher than that of NC rats, calcium excretion by Cd-treated rats fed TB-supplemented diets was significantly lower than that of Cd-Co animals. Fecal cadmium excretion by all Cd-treated rats fed TB-supplemented diets was significantly higher than that of Cd-Co animals. In conclusion, this study provides experimental evidence that various TBs may regulate cadmium-induced organ toxicity by reducing cadmium accumulation in tissues through the mechanism of increasing the fecal excretion of cadmium.
참고문헌 (41)
- 布目潮渢, "中國茶書全集", pp.97~, 汲古書院
- Trevisanato, S.I., "Tea and health.", Nutr. Rev, 58, pp.1~10 (2000)
- Shin, M.K., "Green tea science", Korean J. Dietary Culture, 9, pp.433~445 (1994)
- Choi, O.J., "The physicochemical properties of Korean wild teas (green tea, semi fermented tea, and black tea) according to degree of fermentation", J. Korean Soc. Food Sci. Nutr, 32, pp.356~362 (2003)
- Chen, Z.Y., "Stabilizing effect of ascorbic acid on green tea catechins", J. Agric. Food Chem, 46, pp.2512~2516 (1998)
- Nagai, K., "(-)-Epigallocatechin gallate protects against NO stress-induced neuronal damage after ischemia by acting as an anti-oxidant", Brain Res, 956, pp.319~322 (2002)
- Chung, F.L., "Tea and cancer prevention: Studies in animals and humans", J. Nutr, 133, pp.3268S~3274S (2003)
- Skrzydlewska, E., "Green tea supplementation in rats of different ages mitigates ethanol-induced changes in brain antioxidant abilities", Alcohol, 37, pp.89~98 (2005)
- Hodgson, J.M., "Effects on blood pressure of drinking green and black tea", J. Hypertension, 17, pp.457~463 (1999)
- Abe, K., "The anti-fibrotic effect of green tea with a high catechin content in the galactosamine- injured rat liver", Biomed. Res, 28, pp.43~48 (2007)
- Won, S.M., "Catechins inhibits angiotensin II-induced cascular smooth muscle cell proliferation via mitogen- activated protein kinase pathway", Exp. Mol. Med, 38, pp.525~534 (2006)
- Yeh, C.W., "Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: A possible mechanism for their hypolipidemic effects", Pharmacogenomics, J3, pp.267~276 (2003)
- Chang, L.K., "Inhibition of Epstein-Barr virus lytic cycle by (-)-epigallocatechin gallate", Biochem. Biophys. Res. Commun, 301, pp.1062~1068 (2003)
- Wolfram, S., "Anti- obesity effects of green tea: from beside to bench", Mol. Nutr. Food Res, 50, pp.176~187 (2006)
- Song, E.K., "Epigallocatechin gallate prevents autoimmune diabetes induced by multiple low doses of streptozotocin in mice", Arch. Pharm. Res, 26, pp.559~563 (2003)
- Hodgson, J.M., "Acute effects of ingestion of black tea on postprandial platelet aggregation in human subjects", Br. J. Nutr, 87, pp.141~145 (2002)
- Feng, Q., "Black tea polyphenols, theaflavins, prevent cellular DNA damage by inhibiting oxidative stress and suppressing cytichrome p450 1A1 in cell cultures", J. Agric. Food Chem, 50, pp.213~220 (2002)
- Sarkar, S., "Effect of black tea on teeth", J. Indian Soc. Pedod. Prev. Dent, 18, pp.139~140 (2000)
- 김미지, "만성 카드뮴 중독 흰쥐에서 카드뮴 축적과 배설에 미치는 Vitamin E의 영향", 한국영양학회지, 36(7), pp.691~698 (2003), 한국영양학회
- 구성자, "보이차(Camellia sinensis LINNE) 추출물이 정상인의 알코올 농도와 숙취에 미치는 효과", 한국식품조리과학회지, 21(5), pp.591~598 (2005), 한국식품조리과학회
- Kim, M.J., "Effect of Korean green tea, oolong tea and black tea beverage on the removal of cadmium in rat", J. Korean Soc. Food Nutr, 23, pp.784~791 (1994)
- Itokawa, Y., "Renal and skeletal lesions in experimental cadmium poisoning: histological and biochemical approaches", Arch. Environ. Health, 28, pp.149~154 (1974)
- Bains, R.J., "Dietary cadmium iron and zinc interaction in the growing rat", Proc. Exp. Biol. Med, 130, pp.802~830 (1969)
- Perry, H.M., "Hypertension and tissue metal levels following intravenous cadmium, mercury and zinc", Am. J. Physiol, 210, pp.755~761 (1970)
- Neathery, M.W., "Metabolism and toxicity of cadmium, mercury and lead in animals", J. Dairy Sci, 58, pp.1767~1781 (1975)
- 김미지, "만성 카드뮴 중독 흰쥐에서 카드뮴 축적과 배설에 미치는 Vitamin E의 영향", 한국영양학회지, 36(7), pp.691~698 (2003), 한국영양학회
- Han, S.H., "Effects of the Omija (Schizandra chinensis Baillon) extract on the metabolism and renal cadmium contents in cadmium administered rats.", J. Korean Soc. Food Sci. Nutr, 31, pp.1102~1106 (2002)
- Kim, M.J., "Effects of Korean green tea, oolong and black tea beverage on the removal of cadmium in rat", J. Korean Soc. Food Nutr, 23, pp.784~791 (1994)
- Meilgaard, M., "Sensory Evaluation Techniques", pp.39~112 (1987), CRC Press, Inc
- A.O.A.C, "Official Methods of Analysis", pp.237~ (1990), Association of Official Analytical Chemists
- Han, S.H., "Effects of the Omija (Schizandra chinensis Baillon) extracts on the metabolism and renal cadmium contents in cadmium administerd rats", J. Korean Soc. Food Sci. Nutr, 31, pp.1102~1106 (2002)
- Jin, H.H., "Hypocholesterolemic effects of green tea in cholesterol fed rats", J. Korean Soc. Food Sci. Nutr, 33, pp.47~51 (2004)
- Bradley, L.B., "Uncoupling of oxidative phosphorylation by cadmium ion", J. Biol. Chem, 223, pp.147~156 (1956)
- Cousins, R.J., "Cadmium toxicity in growing swine", J. Nutr, 964, pp.103~110 (1973)
- Torrason, M., "Interaction between calcium and cadmium in the 1,25-dihydroxy vitamin D3 stimulated rat duodenum", Toxicol. Appl. Pharmacol, 75, pp.98~104 (1984)
- Choi, S.I., "Effect of green tea beverage for the removal of cadmium and lead by animal experiments", Korean J. Food Sci. Technol, 26, pp.745~749 (1994)
- 최서진, "포도의 부위별 섭취가 흰쥐의 노화 과정 중 Cadmium의 대사 및 중독에 미치는 영향", 한국영양학회지, 36(10), pp.997~1012 (2003), 한국영양학회
- Lee, S.K., "Concentration of survey heavy metals in normal Korean tissues", Kor. J. Env. Hlth. Soc, 25, pp.7~14 (1999)
- 한종현, "오리부산물과 한약재를 이용한 추출액의 영양성분 및 중금속 노출에 대한 피해 완화 효과(Ⅱ) 중금속 노출에 대한 오리추출액의 피해 완화 효과", 동아시아식생활학회지, 13(4), pp.293~304 (2003), 동아시아식생활학회
- Yoon, Y.H., "Effects of Korean green tea, oolong tea and black tea beverage on the antioxidative detoxification in rat poisoned with cadmium", Korean J. Nutr, 27, pp.1007~1017 (1994)
- Kim, H.J., "Effect of hesperidin extracted from tangerine peel on Cd and lipid metabolism, and antioxidative capacity in rats", Korean J. Food Nutr, 32, pp.137~149 (1999)