본문 바로가기
KERD
논문KCI 등재

Serum vitamin D status and metabolic syndrome: a systematic review and dose-response meta-analysis

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

BACKGROUD/OBJECTIVES: Evidence has suggested an association between serum vitamin D and metabolic syndrome (MetS), but prospective studies are very limited. The objective was to assess the dose-response association between serum vitamin D concentration and MetS risk using a systematic review and meta-analysis of updated observational studies. MATERIALS/METHODS: Using MEDLINE, PubMed, and Embase, a systematic literature search was conducted through February 2020 and the references of relevant articles were reviewed. A random-effects model was used to estimate the summary odds ratio/relative risk and 95% confidence interval (CI). Heterogeneity among studies was evaluated with I2 statistic. In total, 23 observational studies (19 cross-sectional studies, and four cohort studies) were included in the meta-analysis. RESULTS: The pooled estimates (95% CI) for MetS per 25-nmol/L increment in serum vitamin D concentration were 0.80 (95% CI, 0.76–0.84; I2 = 53.5) in cross-sectional studies, and 0.85 (95% CI, 0.72–0.98; I2 = 85.8) in cohort studies. Similar results were observed, irrespectively of age of study population, study location, MetS criteria, and adjustment factors. There was no publication bias for the dose-response meta-analysis of serum vitamin D concentrations and MetS. CONCLUSIONS: Dose-response meta-analysis demonstrated that a 25-nmol/L increment in the serum vitamin D concentration was associated with 20% and 15% lower risks of MetS in cross-sectional studies and cohort studies, respectively.

Abstract

BACKGROUD/OBJECTIVES: Evidence has suggested an association between serum vitamin D and metabolic syndrome (MetS), but prospective studies are very limited. The objective was to assess the dose-response association between serum vitamin D concentration and MetS risk using a systematic review and meta-analysis of updated observational studies. MATERIALS/METHODS: Using MEDLINE, PubMed, and Embase, a systematic literature search was conducted through February 2020 and the references of relevant articles were reviewed. A random-effects model was used to estimate the summary odds ratio/relative risk and 95% confidence interval (CI). Heterogeneity among studies was evaluated with I2 statistic. In total, 23 observational studies (19 cross-sectional studies, and four cohort studies) were included in the meta-analysis. RESULTS: The pooled estimates (95% CI) for MetS per 25-nmol/L increment in serum vitamin D concentration were 0.80 (95% CI, 0.76–0.84; I2 = 53.5) in cross-sectional studies, and 0.85 (95% CI, 0.72–0.98; I2 = 85.8) in cohort studies. Similar results were observed, irrespectively of age of study population, study location, MetS criteria, and adjustment factors. There was no publication bias for the dose-response meta-analysis of serum vitamin D concentrations and MetS. CONCLUSIONS: Dose-response meta-analysis demonstrated that a 25-nmol/L increment in the serum vitamin D concentration was associated with 20% and 15% lower risks of MetS in cross-sectional studies and cohort studies, respectively.

참고문헌 (63)

  1. Holick MF, "Vitamin D deficiency : a worldwide problem with health consequences", Am J Clin Nutr, 87, pp.1080S~1086S (2008)
  2. Mithal A, "IOF Committee of Scientific Advisors (CSA) Nutrition Working Group. Global vitamin D status and determinants of hypovitaminosis D", Osteoporos Int, 20, pp.1807~1820 (2009)
  3. Wahl DA, "A global representation of vitamin D status in healthy populations", Arch Osteoporos, 7, pp.155~172 (2012)
  4. Palacios C, "Is vitamin D deficiency a major global public health problem?", J Steroid Biochem Mol Biol., 144(Pt A), pp.138~145 (2014)
  5. Kim M, "Correlation between vitamin D and cardiovascular disease predictors in overweight and obese Koreans", J Clin Biochem Nutr, 52, pp.167~171 (2013)
  6. Anderson JL, "Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population", Am J Cardiol, 106, pp.963~968 (2010)
  7. Botella-Carretero JI, "Vitamin D deficiency is associated with the metabolic syndrome in morbid obesity", Clin Nutr, 26, pp.573~580 (2007)
  8. Wilson PW, "Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus", Circulation, 112, pp.3066~3072 (2005)
  9. Wu SH, "Metabolic syndrome and all-cause mortality : a meta-analysis of prospective cohort studies", Eur J Epidemiol, 25, pp.375~384 (2010)
  10. Borch-Johnsen K., "The metabolic syndrome in a global perspective. The public health impact--secondary publication", Dan Med Bull, 54, pp.157~159 (2007)
  11. Lee SE, "Taskforce Team of Diabetes Fact Sheet of the Korean Diabetes Association. Trends in the prevalence of metabolic syndrome and its components in South Korea: findings from the Korean National Health Insurance Service Database (2009–2013)", PLoS One, 13, pp.e0194490~ (2018)
  12. Lu Y, "Low levels of serum 25-hydroxyvitamin D and risk of metabolic syndrome in China", Int J Clin Exp Med, 8, pp.13790~13796 (2015)
  13. Pannu PK, "The associations of vitamin D status and dietary calcium with the metabolic syndrome : an analysis of the Victorian Health Monitor survey", Public Health Nutr, 20, pp.1785~1796 (2017)
  14. Ju SY, "Blood vitamin D status and metabolic syndrome in the general adult population : a dose-response meta-analysis", J Clin Endocrinol Metab, 99, pp.1053~1063 (2014)
  15. Parker J, "Levels of vitamin D and cardiometabolic disorders : systematic review and meta-analysis", Maturitas, 65, pp.225~236 (2010)
  16. Pham TM, "The effect of changing serum 25-hydroxyvitamin D concentrations on metabolic syndrome : a longitudinal analysis of participants of a preventive health program", Nutrients, 7, pp.7271~7284 (2015)
  17. Modesti PA, "ESH Working Group on CV Risk in Low Resource Settings. Panethnic differences in blood pressure in Europe: a systematic review and meta-analysis", PLoS One, 11, pp.e0147601~ (2016)
  18. Greenland S, "Methods for trend estimation from summarized dose-response data, with applications to meta-analysis", Am J Epidemiol, 135, pp.1301~1309 (1992)
  19. Gao Y, "Relationship between vitamin D level and the incidence of metabolic syndrome in adults in Chengdu city : a prospective cohort study", Chin J Evid-Based Med, 17, pp.1121~1126 (2017)
  20. Majumdar V, "Vitamin D status and metabolic syndrome in Asian Indians", Int J Obes, 35, pp.1131~1134 (2011)
  21. Reis JP, "Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults", Diabetes Care, 30, pp.1549~1555 (2007)
  22. Orsini N, "Generalized least squares for trend estimation of summarized dose-response data", Stata J, 6, pp.40~57 (2006)
  23. Higgins JP, "Quantifying heterogeneity in a meta-analysis", Stat Med, 21, pp.1539~1558 (2002)
  24. Higgins JP, "Measuring inconsistency in meta-analyses", BMJ, 327, pp.557~560 (2003)
  25. Egger M, "Bias in meta-analysis detected by a simple, graphical test", BMJ, 315, pp.629~634 (1997)
  26. Begg CB, "Operating characteristics of a rank correlation test for publication bias", Biometrics, 50, pp.1088~1101 (1994)
  27. Furuya-Kanamori L, "A new improved graphical and quantitative method for detecting bias in meta-analysis", Int J Evid-Based Healthc, 16, pp.195~203 (2018)
  28. Akter S, "Serum 25-hydroxyvitamin D and metabolic syndrome in a Japanese working population : the Furukawa Nutrition and Health Study", Nutrition, 36, pp.26~32 (2017)
  29. Amirbaigloo A, "Absence of association between vitamin D deficiency and incident metabolic syndrome : Tehran Lipid and Glucose Study", Metab Syndr Relat Disord, 11, pp.236~242 (2013)
  30. Bea JW, "Concentrations of the vitamin D metabolite 1, 25(OH)2D and odds of metabolic syndrome and its components", Metabolism, 64, pp.447~459 (2015)
  31. Chacko SA, "Serum 25-hydroxyvitamin D concentrations in relation to cardiometabolic risk factors and metabolic syndrome in postmenopausal women", Am J Clin Nutr, 94, pp.209~217 (2011)
  32. Ford ES, "Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults", Diabetes Care, 28, pp.1228~1230 (2005)
  33. Huang CY, "Vitamin D status and risk of metabolic syndrome among non-diabetic young adults", Clin Nutr, 34, pp.484~489 (2015)
  34. Hyppönen E, "25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age : a cross-sectional study in the 1958 British Birth Cohort", Diabetes, 57, pp.298~305 (2008)
  35. Kim MK, "The association of serum vitamin D level with presence of metabolic syndrome and hypertension in middle-aged Korean subjects", Clin Endocrinol(Oxf), 73, pp.330~338 (2010)
  36. Lee DM, "Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men", Eur J Endocrinol, 161, pp.947~954 (2009)
  37. Lu L, "Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals", Diabetes Care, 32, pp.1278~1283 (2009)
  38. Maki KC, "Vitamin D intake and status are associated with lower prevalence of metabolic syndrome in U.S. adults: National Health and Nutrition Examination Surveys 2003–2006", Metab Syndr Relat Disord, 10, pp.363~372 (2012)
  39. Gagnon C, "Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years : results from a national, population-based prospective study(the Australian Diabetes, Obesity and Lifestyle Study : AusDiab)", J Clin Endocrinol Metab, 97, pp.1953~1961 (2012)
  40. Vitezova A, "Vitamin D status and metabolic syndrome in the elderly : the Rotterdam Study", Eur J Endocrinol, 172, pp.327~335 (2015)
  41. Huang H, "The synergistic effects of vitamin D and estradiol deficiency on metabolic syndrome in Chinese postmenopausal women", Menopause, 26, pp.1171~1177 (2019)
  42. Yeap BB, "U-shaped association of vigorous physical activity with risk of metabolic syndrome in men with low lean mass, and no interaction of physical activity and serum 25-hydroxyvitamin D with metabolic syndrome risk", Intern Med J, 50, pp.460~469 (2020)
  43. Ganji V, "Serum vitamin D concentrations are inversely related to prevalence of metabolic syndrome in Qatari women", Biofactors, 46, pp.180~186 (2020)
  44. Weldegiorgis TZ, "Association between serum 25-hydroxyvitamin D concentrations and metabolic syndrome in the middle-aged and elderly Chinese population in Dalian, northeast China : a cross-sectional study", J Diabetes Investig, 11, pp.184~191 (2020)
  45. Khan H, "Vitamin D, type 2 diabetes and other metabolic outcomes : a systematic review and meta-analysis of prospective studies", Proc Nutr Soc, 72, pp.89~97 (2013)
  46. Khosravi ZS, "Effect of vitamin D supplementation on weight loss, glycemic indices, and lipid profile in obese and overweight women : a clinical trial study", Int J Prev Med, 9, pp.63~ (2018)
  47. Salekzamani S, "Effect of high-dose vitamin D supplementation on cardiometabolic risk factors in subjects with metabolic syndrome : a randomized controlled double-blind clinical trial", J Endocrinol Invest, 39, pp.1303~1313 (2016)
  48. Talaei A, "The effect of vitamin D on insulin resistance in patients with type 2 diabetes", Diabetol Metab Syndr, 5, pp.8~ (2013)
  49. Griffin FC, "Vitamin D and subsequent systolic hypertension among women", Am J Hypertens, 24, pp.316~321 (2011)
  50. Chiu KC, "Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction", Am J Clin Nutr, 79, pp.820~825 (2004)
  51. Liu HX, "Adipocyte differentiation is regulated by mitochondrial trifunctional protein α-subunit via sirtuin 1", Exp Cell Res, 357, pp.271~281 (2017)
  52. Ye X, "Sirtuins in glucose and lipid metabolism", Oncotarget, 8, pp.1845~1859 (2017)
  53. Chang E, "Vitamin D decreases adipocyte lipid storage and increases NAD-SIRT1 pathway in 3T3-L1 adipocytes", Nutrition, 32, pp.702~708 (2016)
  54. Vaidya A, "The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes", Metabolism, 61, pp.450~458 (2012)
  55. Li YC, "Vitamin D regulation of the renin-angiotensin system", J Cell Biochem, 88, pp.327~331 (2003)
  56. Pilz S, "Vitamin D, cardiovascular disease and mortality", Clin Endocrinol(Oxf), 75, pp.575~584 (2011)
  57. Pilz S, "Parathyroid hormone level is associated with mortality and cardiovascular events in patients undergoing coronary angiography", Eur Heart J, 31, pp.1591~1598 (2010)
  58. Snijder MB, "Vitamin D status and parathyroid hormone levels in relation to blood pressure : a population-based study in older men and women", J Intern Med, 261, pp.558~565 (2007)
  59. Ahlström T, "Correlation between plasma calcium, parathyroid hormone(PTH)and the metabolic syndrome(MetS)in a community-based cohort of men and women", Clin Endocrinol(Oxf), 71, pp.673~678 (2009)
  60. Garbossa SG, "A window on a potential role for the interaction between bone and glucose metabolism", Rev Endocr Metab Disord, 18, pp.243~258 (2017)
  61. Neve A, "Immunomodulatory effects of vitamin D in peripheral blood monocyte-derived macrophages from patients with rheumatoid arthritis", Clin Exp Med, 14, pp.275~283 (2014)
  62. Giulietti A, "Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1,25-dihydroxyvitamin D(3) works as anti-inflammatory", Diabetes Res Clin Pract, 77, pp.47~57 (2007)
  63. VanderWeele TJ, "Sensitivity analysis in observational research : introducing the E-value", Ann Intern Med, 167, pp.268~274 (2017)

관련 논문AI추천

이 간행물의 다른 논문 (9건)