Circulating 25-hydroxyvitamin D levels and hypertension risk after adjusting for publication bias
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Previous systematic reviews reported that serum vitamin D deficiency was associated with risk of hypertension. The aim was to conduct a meta-epidemiological analysis for evaluating the potential effects of publication bias. Methods: The selection criterion was defined as a follow-up study for evaluating the association between circulating 25-hydroxyvitam D level and hypertension risk in adults. A funnel plot and Egger's test were used to detect a publication bias. If a publication bias was identified, trim-and-fill analysis (TFA) with linear estimator was performed to estimate a summary relative risk (sRR). Results: The meta-analysis of 13 cohorts resulted in the lower the vitamin D, the higher the risk of hypertension statistically significant (sRR, 1.22; 95% confidence interval [CI], 1.05 to 1.41). But The P-value of Egger's test (=0.015) and asymmetry of the funnel plot showed that there was a publication bias. TFA resulted in that statistical significance disappeared in the association between vitamin D level and hypertension risk in total cohorts (filled sRR, 1.03; 95% CI, 0.89 to 1.18) as well as men and women cohorts. Conclusions: The publication bias-adjusted results by TFA had no statistically significant association between vitamin D levels and the risk of hypertension. The significant results in previous systematic reviews might be interpreted as due to publication bias.
Abstract
Background: Previous systematic reviews reported that serum vitamin D deficiency was associated with risk of hypertension. The aim was to conduct a meta-epidemiological analysis for evaluating the potential effects of publication bias. Methods: The selection criterion was defined as a follow-up study for evaluating the association between circulating 25-hydroxyvitam D level and hypertension risk in adults. A funnel plot and Egger's test were used to detect a publication bias. If a publication bias was identified, trim-and-fill analysis (TFA) with linear estimator was performed to estimate a summary relative risk (sRR). Results: The meta-analysis of 13 cohorts resulted in the lower the vitamin D, the higher the risk of hypertension statistically significant (sRR, 1.22; 95% confidence interval [CI], 1.05 to 1.41). But The P-value of Egger's test (=0.015) and asymmetry of the funnel plot showed that there was a publication bias. TFA resulted in that statistical significance disappeared in the association between vitamin D level and hypertension risk in total cohorts (filled sRR, 1.03; 95% CI, 0.89 to 1.18) as well as men and women cohorts. Conclusions: The publication bias-adjusted results by TFA had no statistically significant association between vitamin D levels and the risk of hypertension. The significant results in previous systematic reviews might be interpreted as due to publication bias.
참고문헌 (36)
- Wang L, "Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease : a meta-analysis of prospective studies", Circ Cardiovasc Qual Outcomes, 5, pp.819~829 (2012)
- Pilz S, "Vitamin D and cardiovascular disease prevention", Nat Rev Cardiol, 13, pp.404~417 (2016)
- Al Mheid I, "Vitamin D and cardiovascular disease : controversy unresolved", J Am Coll Cardiol, 70, pp.89~100 (2017)
- Holick MF, "Vitamin D deficiency", N Engl J Med, 357, pp.266~281 (2007)
- 정혜윤, "Vitamin D and Hypertension", Electrolytes & Blood Pressure, 15(1), pp.1~11 (2017), 전해질고혈압연구회[DOI]
- Pittas AG, "Systematic review : vitamin D and cardiometabolic outcomes", Ann Intern Med, 152, pp.307~314 (2010)
- Burgaz A, "Blood 25-hydroxyvitamin D concentration and hypertension : a meta-analysis", J Hypertens, 29, pp.636~645 (2011)
- Kunutsor SK, "Vitamin D and risk of future hypertension : meta-analysis of 283, 537 participants", Eur J Epidemiol, 28, pp.205~221 (2013)
- Qi D, "Vitamin D and hypertension : prospective study and meta-analysis", PLoS One, 12, pp.e0174298~ (2017)
- Chen CH, "Associations between vitamin D deficiency, musculoskeletal health, and cardiometabolic risk among community-living people in Taiwan : Age and sex-specific relationship", Medicine(Baltimore), 97, pp.e13886~ (2018)
- Murad MH, "Guidelines for reporting meta-epidemiological methodology research", Evid Based Med, 22, pp.139~142 (2017)
- Forman JP, "Plasma 25-hydroxyvitamin D levels and risk of incident hypertension", Hypertension, 49, pp.1063~1069 (2007)
- Forman JP, "Plasma 25-hydroxyvitamin D levels and risk of incident hypertension among young women", Hypertension, 52, pp.828~832 (2008)
- Anderson JL, "Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population", Am J Cardiol, 106, pp.963~968 (2010)
- Jorde R, "Serum 25-hydroxyvitamin D levels are strongly related to systolic blood pressure but do not predict future hypertension", Hypertension, 55, pp.792~798 (2010)
- Griffin FC, "Vitamin D and subsequent systolic hypertension among women", Am J Hypertens, 24, pp.316~321 (2011)
- Margolis KL, "A prospective study of serum 25-hydroxyvitamin D levels, blood pressure, and incident hypertension in postmenopausal women", Am J Epidemiol, 175, pp.22~32 (2012)
- Skaaby T, "Vitamin D status and changes in cardiovascular risk factors : a prospective study of a general population", Cardiology, 123, pp.62~70 (2012)
- Wang L, "A prospective study of plasma vitamin D metabolites, vitamin D receptor gene polymorphisms, and risk of hypertension in men", Eur J Nutr, 52, pp.1771~1779 (2013)
- van Ballegooijen AJ, "Association of 25-hydroxyvitamin D and parathyroid hormone with incident hypertension : MESA(Multi-Ethnic Study of Atherosclerosis)", J Am Coll Cardiol, 63, pp.1214~1222 (2014)
- Ke L, "Hypertension, pulse, and other cardiovascular risk factors and vitamin D status in Finnish men", Am J Hypertens, 26, pp.951~956 (2013)
- 배종면, "Citation Discovery Tools for Conducting Adaptive Meta-analyses to Update Systematic Reviews", 예방의학회지, 49(2), pp.129~133 (2016), 대한예방의학회
- Harris RJ, "metan : Fixed-and random-effects meta-analysis", Stata J, 8, pp.3~28 (2008)
- Song F, "Dissemination and publication of research findings : an updated review of related biases", Health Technol Assess, 14, pp.1~193 (2010)
- Moreno SG, "Assessment of regression-based methods to adjust for publication bias through a comprehensive simulation study", BMC Med Res Methodol, 9, pp.2~ (2009)
- Duval S, "Trim and fill : a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis", Biometrics, 56, pp.455~463 (2000)
- Peters JL, "Performance of the trim and fill method in the presence of publication bias and between-study heterogeneity", Stat Med, 26, pp.4544~4562 (2007)
- Peng M, "Dissociation between low vitamin D level and hypertension in coal mine workers : evidence from the Kailuan study", Intern Med, 55, pp.1255~1260 (2016)
- Mirhosseini N, "The association between serum 25(OH)D status and blood pressure in participants of a community-based program taking vitamin D supplements", Nutrients, 9, pp.1244~ (2017)
- van Ballegooijen AJ, "Plasma 1, 25-dihydroxyvitamin D and the risk of developing hypertension : the prevention of renal and vascular end-stage disease study", Hypertension, 66, pp.563~570 (2015)
- Zhang D, "Effect of vitamin D on blood pressure and hypertension in the general population : an update meta-analysis of cohort studies and randomized controlled trials", Prev Chronic Dis, 17, pp.E03~ (2020)
- Hayashino Y, "Systematic evaluation and comparison of statistical tests for publication bias", J Epidemiol, 15, pp.235~243 (2005)
- Terrin N, "In an empirical evaluation of the funnel plot, researchers cound not visually identify publication bias", J Clin Epidemiol, 58, pp.894~901 (2005)
- Ioannidis JP, "The appropriateness of asymmetry tests for publication bias in meta-analyses : a large survey", CMAJ, 176, pp.1091~1096 (2007)
- Murad MH, "The effect of publication bias magnitude and direction on the certainty in evidence", BMJ Evid Based Med, 23, pp.84~86 (2018)
- Mavridis D, "Exploring and accounting for publication bias in mental health : a brief overview of methods", Evid Based Ment Health, 17, pp.11~15 (2014)