Differences of Aortic Stiffness and Aortic Intima-Media Thickness According to the Type of Initial Presentation in Patients with Ischemic Stroke
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Background: Aortic stiffness and intima-media thickness (IMT) are known to be associated with ischemic stroke. The aim of the present study was to investigate the differences of aortic stiffness and IMT between cerebral infarction (CI) and transient ischemic attack (TIA). Methods: A total of 500 patients with acute stroke were divided into 2 groups: the TIA group (n = 230, 62.4 ± 12 years, 144males) versus CI group (n = 270, 63.4 ± 11 years, 181 males). Aortic stiffness index and IMT, as well as conventional cardiovascular risk factors, were compared. Results: The prevalence of hypertension, diabetes, and dyslipidemia were significantly higher, and left atrial volume and E/E’were significantly elevated in the CI group than in the TIA group. Carotid IMT was significantly thicker in the CI group than in the TIA group. Aortic stiffness index β was significantly higher (7.99 ± 2.70 vs. 7.02 ± 4.30, p = 0.043) and aortic IMT was significantly thicker (1.53 ± 0.41 vs. 1.45 ± 0.39 mm, p = 0.040) in the CI group than in the TIA group. Aortic stiffness index β was significantly correlated with the IMT of the aorta (r = 0.279, p = 0.014), right (r = 412, p < 0.001) and left carotid artery (r =441, p < 0.001). Conclusion: Aortic stiffness index β and IMT were significantly higher in patients with CI than TIA. The result of the present study suggested that CI is associated with more advanced degree of atherosclerotic and arteriosclerotic process than TIA.
Abstract
Background: Aortic stiffness and intima-media thickness (IMT) are known to be associated with ischemic stroke. The aim of the present study was to investigate the differences of aortic stiffness and IMT between cerebral infarction (CI) and transient ischemic attack (TIA). Methods: A total of 500 patients with acute stroke were divided into 2 groups: the TIA group (n = 230, 62.4 ± 12 years, 144males) versus CI group (n = 270, 63.4 ± 11 years, 181 males). Aortic stiffness index and IMT, as well as conventional cardiovascular risk factors, were compared. Results: The prevalence of hypertension, diabetes, and dyslipidemia were significantly higher, and left atrial volume and E/E’were significantly elevated in the CI group than in the TIA group. Carotid IMT was significantly thicker in the CI group than in the TIA group. Aortic stiffness index β was significantly higher (7.99 ± 2.70 vs. 7.02 ± 4.30, p = 0.043) and aortic IMT was significantly thicker (1.53 ± 0.41 vs. 1.45 ± 0.39 mm, p = 0.040) in the CI group than in the TIA group. Aortic stiffness index β was significantly correlated with the IMT of the aorta (r = 0.279, p = 0.014), right (r = 412, p < 0.001) and left carotid artery (r =441, p < 0.001). Conclusion: Aortic stiffness index β and IMT were significantly higher in patients with CI than TIA. The result of the present study suggested that CI is associated with more advanced degree of atherosclerotic and arteriosclerotic process than TIA.
참고문헌 (21)
- Arnett DK, "Arterial stiffness: a new cardiovascular risk factor?", Am J Epidemiol, 140, pp.669~682 (1994)
- Mattace-Raso FU, "Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study", Circulation, 113, pp.657~663 (2006)
- Tuttolomondo A, "Arterial stiffness indexes in acute ischemic stroke: relationship with stroke subtype", Atherosclerosis, 211, pp.187~194 (2010)
- Blankenhorn DH, "Noninvasive assessment of atherosclerosis", Prog Cardiovasc Dis, 26, pp.295~307 (1984)
- Pignoli P, "Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging", Circulation, 74, pp.1399~1406 (1986)
- Bots ML, "Carotid intima-media thickness as a surrogate marker for cardiovascular disease in intervention studies", Curr Med Res Opin, 22, pp.2181~2190 (2006)
- Nemes A, "Increased aortic stiffness in glycogenosis type 2 (Pompe’s disease)", Int J Cardiol, 120, pp.138~141 (2007)
- Geroulakos G, "The carotid intima-media thickness as a marker of the presence of severe symptomatic coronary artery disease", Eur Heart J, 15, pp.781~785 (1994)
- Asmar R, "Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies", Hypertension, 26, pp.485~490 (1995)
- Lehmann ED, "Validation and reproducibility of pressure-corrected aortic distensibility measurements using pulse-wave-velocity Doppler ultrasound", J Biomed Eng, 15, pp.221~228 (1993)
- Young W, "The quantitation of atherosclerosis: III. The extent of correlation of degrees of atherosclerosis within and between the coronary and cerebral vascular beds", Am J Cardiol, 6, pp.300~308 (1960)
- Dijk JM, "SMART Study Group. Carotid stiffness indicates risk of ischemic stroke and TIA in patients with internal carotid artery stenosis: the SMART study", Stroke, 35, pp.2258~2262 (2004)
- Sugioka K, "Impact of aortic stiffness on ischemic stroke in elderly patients", Stroke, 33, pp.2077~2081 (2002)
- Heiss G, "Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study", Am J Epidemiol, 134, pp.250~256 (1991)
- Eren M, "Relation between aortic stiffness and left ventricular diastolic function in patients with hypertension, diabetes, or both", Heart, 90, pp.37~43 (2004)
- Geroulakos G, "Carotid intima-media thickness: correlation with the British Regional Heart Study risk score", J Intern Med, 235, pp.431~433 (1994)
- Stefanadis C, "Aortic distensibility abnormalities in coronary artery disease", Am J Cardiol, 59, pp.1300~1304 (1987)
- Mitchell JR, "Relationship between arterial disease in different sites. A study of the aorta and coronary, carotid, and iliac arteries", Br Med J, 1, pp.1293~1301 (1962)
- Abhayaratna WP, "Relation of arterial stiffness to left ventricular diastolic function and cardiovascular risk prediction in patients > or =65 years of age", Am J Cardiol, 98, pp.1387~1392 (2006)
- Hertzer NR, "Coronary angiography in 506 patients with extracranial cerebrovascular disease", Arch Intern, 145, pp.849~852 (1985)
- 윤현주, "관상동맥 질환 환자에서 하행 흉부대동맥 내중막 두께의 임상적 의의", Korean Circulation Journal, 37(8), pp.365~372 (2007), 대한심장학회