뇌졸중 환자에서 맥파전파속도와 동맥경화 위험인자와의 상관관계
The Correlation of Pulse Wave Velocity and Atherosclerotic Risk Factor in Stroke Patients
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초록
Pulse wave velocity (PWV) is used to non-invasively estimate the severity of arteriosclerosis by measuring arterial stiffness. Increased arterial stiffness measured by PWV stands for progressive arteriosclerosis and is caused by atherosclerotic risk factors. This study is focused on how brachial-ankle pulse wave velocity (baPWV) is related to the leading risk factors for arteriosclerosis or atherosclerosis. Subjects were 114, 69 males and 45 females who are in 60's and had baPWV test for acute stroke. The results are as follows: the group with increased arterial stiffness showed significant increase in HbA1c, total cholesterol, BSBP (brachial artery systolic blood pressure), BDBP (brachial artery diastolic blood pressure), CSBP (central artery systolic blood pressure), CDBP (central artery diastolic blood pressure), augmentation index (AIx) and diabetes mellitus. Correlation analysis between baPWV and atherosclerotic risk factor showed significant relationship in age, HbA1c, LDL cholesterol, BSBP, BDBP, CSBP, CDBP and augmentation index. baPWV was independently related to age and BSBP in multiple linear regression analysis. The group with increased arterial stiffness was independently related to BDBP in multiple logistic regression analysis. This study might be meaningful in evaluating the relationship between arterial stiffness and atherosclerotic risk factor in a new way, and be helped to make various studies for cardiovascular disease.
Abstract
Pulse wave velocity (PWV) is used to non-invasively estimate the severity of arteriosclerosis by measuring arterial stiffness. Increased arterial stiffness measured by PWV stands for progressive arteriosclerosis and is caused by atherosclerotic risk factors. This study is focused on how brachial-ankle pulse wave velocity (baPWV) is related to the leading risk factors for arteriosclerosis or atherosclerosis. Subjects were 114, 69 males and 45 females who are in 60's and had baPWV test for acute stroke. The results are as follows: the group with increased arterial stiffness showed significant increase in HbA1c, total cholesterol, BSBP (brachial artery systolic blood pressure), BDBP (brachial artery diastolic blood pressure), CSBP (central artery systolic blood pressure), CDBP (central artery diastolic blood pressure), augmentation index (AIx) and diabetes mellitus. Correlation analysis between baPWV and atherosclerotic risk factor showed significant relationship in age, HbA1c, LDL cholesterol, BSBP, BDBP, CSBP, CDBP and augmentation index. baPWV was independently related to age and BSBP in multiple linear regression analysis. The group with increased arterial stiffness was independently related to BDBP in multiple logistic regression analysis. This study might be meaningful in evaluating the relationship between arterial stiffness and atherosclerotic risk factor in a new way, and be helped to make various studies for cardiovascular disease.
참고문헌 (23)
- Amar J, "Arterial stiffness and cardiovascular risk factors in a population based study", J Hypertens, 19, pp.381~387 (2001)
- Blacher J, "Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients", Hypertension, 33, pp.1111~1117 (1999)
- Boutouyrie P, "Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: A longitudinal study", Hypertension, 39, pp.10~15 (2002)
- Choi JC, "Limitation of brachial-ankle pulse wave velocity in assessing the risk of stroke: Importance of instantaneous blood pressure", Cerebrovasc Dis, 27, pp.417~425 (2009)
- Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, "Report of the expert committee on the diagnosis and classification of diabetes mellitus", Diabetes Care, (26Suppl1), pp.S5~S20 (2003)
- Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, "Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP)Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)", JAMA, 285(19), pp.2486~2497 (2001)
- Franklin SS, "Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham Heart Study", Circulation, 100, pp.354~360 (1999)
- Girerd X, "Arterial distensibility and left ventricular hypertrophy in patients with sustained essential hypertension", Am Heart J, 122, pp.1210~1214 (1991)
- Hamilton PK, "Arterial stiffness:Clinical relevance, measurement and treatment", Clin Sci(Lond), 100, pp.387~393 (2011)
- Izzo JL, "Arterial stiffness and the systolic hypertension syndrome", Curr Opin Cardiol, 19, pp.341~352 (2004)
- 진복희, "뇌졸중 환자의 동맥경직도에 따른 임상검사결과와 유병률의 비교", 대한임상검사과학회지, 46(4), pp.143~149 (2014), 대한임상검사과학회
- Jones DW, "Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure and evidence from new hypertension trials", Hypertension, 43(1), pp.1~3 (2004)
- Kim J, "The association between cerebral atherosclerosis and arterial stiffness in acute ischemic stroke", Atherosclerosis, 219(2), pp.887~891 (2011)
- Koji Y, "Comparison of ankle-brachial pressure index and pulse wave velocity as markers of the presence of coronary artery disease in subjects with a high risk of atherosclerotic cardiovascular disease", Am J Cardiol, 94, pp.868~872 (2004)
- Laurent S, "Aortic stiffness is an independent predictor of fatal stroke in essential hypertension", Sroke, 34, pp.1203~1206 (2003)
- London GM, "Influence of sex on arterial hemodynamics and blood pressure:role of body height", Hypertension, 26, pp.514~519 (1995)
- McLeod AL, "Non-invasive measures of pulse wave velocity correlate with coronary arterial plaque load in humans", J Hypertens, 22, pp.363~368 (2004)
- Motobe K, "Cut-off value of the ankle-brachial pressure index at which the accuracy of brachial-ankle pulse wave velocity measurement is diminished", Circulation Journal : official journal of the Japanese Circulation Society, 69(1), pp.55~60 (2005)
- 박진식, "침습적으로 측정한 대동맥 맥파전파속도와 관상동맥 질환의 관계", Korean Circulation Journal, 35(10), pp.766~772 (2005), 대한심장학회
- Relf IR, "Risk factors for changes in aorto-iliac arterial compliance in healthy men", Atherosclerosis, 6, pp.105~108 (1986)
- Sutton-Tyrrell K, "Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults", Circulation, 111, pp.3384~3390 (2005)
- Zieman Sj, "Mechanisms, pathophysiology, and therapy of arterial stiffness", Arterioscler Thromb Vasc Biol, 25, pp.932~943 (2005)
- 조주희, "맥파전파속도와 경동맥 내막-중막 두께 및 경동맥 확장도와의 상관관계", Journal of Cardiovascular Ultrasound, 14(3), pp.92~97 (2006), 한국심초음파학회