Relationship Between MicroRNA Signature and Arterial Stiffness in Patients With Ischemic Stroke
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Background and Purpose We investigated whether circulating microRNAs (miRNAs) is associated with arterial stiffness in patients with acute ischemic stroke. Methods We recruited patients with acute ischemic stroke who were admitted to a university hospital stroke center and underwent carotid-femoral pulse wave velocity (cfPWV) measurement using SphygmoCor (AtCor Medical, Sydney, Australia) and brachial-ankle PWV using a volume-plethysmography device (VP-1000, Omron Colin, Komaki, Japan). Circulating miRNAs were measured in venous blood samples stored in EDTA. We selected five miRNAs (miR-17, miR-93, miR-450, miR-629, and let-7i) related to atherosclerosis based on a literature review. Pearson’s correlation analysis was applied to the correlations between miRNAs and arterial stiffness parameters. Finally, multivariable linear regression analysis was performed to identify the independent factors for cfPWV. Results This study included 70 patients (age=71.1±10.3 years [mean±SD], 29 females). The expression levels of miR-93 (r=-0.27, p=0.049) and let-7i (r=-0.27, p=0.039) were inversely correlated with cfPWV. Multivariable linear regression analysis including age, hypertension, and estimated glomerular filtration rate showed that let-7i was independently related with cfPWV (standardized coefficient=-0.262, p=0.036). Correlation analysis indicated that let-7i was positively associated with visceral muscle Hounsfield units on computed tomography (r=0.264, p=0.043). Conclusions The expression level of let-7i was independently related to arterial stiffness in patients with cerebral infarction, suggesting that it plays a pathophysiological role in atherosclerosis.
Abstract
Background and Purpose We investigated whether circulating microRNAs (miRNAs) is associated with arterial stiffness in patients with acute ischemic stroke. Methods We recruited patients with acute ischemic stroke who were admitted to a university hospital stroke center and underwent carotid-femoral pulse wave velocity (cfPWV) measurement using SphygmoCor (AtCor Medical, Sydney, Australia) and brachial-ankle PWV using a volume-plethysmography device (VP-1000, Omron Colin, Komaki, Japan). Circulating miRNAs were measured in venous blood samples stored in EDTA. We selected five miRNAs (miR-17, miR-93, miR-450, miR-629, and let-7i) related to atherosclerosis based on a literature review. Pearson’s correlation analysis was applied to the correlations between miRNAs and arterial stiffness parameters. Finally, multivariable linear regression analysis was performed to identify the independent factors for cfPWV. Results This study included 70 patients (age=71.1±10.3 years [mean±SD], 29 females). The expression levels of miR-93 (r=-0.27, p=0.049) and let-7i (r=-0.27, p=0.039) were inversely correlated with cfPWV. Multivariable linear regression analysis including age, hypertension, and estimated glomerular filtration rate showed that let-7i was independently related with cfPWV (standardized coefficient=-0.262, p=0.036). Correlation analysis indicated that let-7i was positively associated with visceral muscle Hounsfield units on computed tomography (r=0.264, p=0.043). Conclusions The expression level of let-7i was independently related to arterial stiffness in patients with cerebral infarction, suggesting that it plays a pathophysiological role in atherosclerosis.
참고문헌 (44)
- Virani SS, "Heart disease and stroke statistics—2020 update : a report from the American Heart Association", Circulation, 141, pp.e139~e596 (2020)
- Vasan RS, "Biomarkers of cardiovascular disease : molecular basis and practical considerations", Circulation, 113, pp.2335~2362 (2006)
- Shirwany NA, "Arterial stiffness : a brief review", Acta Pharmacol Sin, 31, pp.1267~1276 (2010)
- Franklin SS, "Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study", Circulation, 96, pp.308~315 (1997)
- Chae CU, "Increased pulse pressure and risk of heart failure in the elderly", JAMA, 281, pp.634~639 (1999)
- Sutton-Tyrrell K, "Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults", Circulation, 111, pp.3384~3390 (2005)
- Mitchell GF, "Pulse pressure and risk of new-onset atrial fibrillation", JAMA, 297, pp.709~715 (2007)
- Mattace-Raso FU, "Arterial stiffness and risk of coronary heart disease and stroke : the Rotterdam Study", Circulation, 113, pp.657~663 (2006)
- Gasecki D, "Aortic stiffness predicts functional outcome in patients after ischemic stroke", Stroke, 43, pp.543~544 (2012)
- Tuttolomondo A, "Arterial stiffness indexes in acute ischemic stroke : relationship with stroke subtype", Atherosclerosis, 211, pp.187~194 (2010)
- Kim VN, "Biogenesis of small RNAs in animals", Nat Rev Mol Cell Biol, 10, pp.126~139 (2009)
- Tiedt S, "Role of non-coding RNAs in stroke", Stroke, 49, pp.3098~3106 (2018)
- Liu DZ, "Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures", J Cereb Blood Flow Metab, 30, pp.92~101 (2010)
- Kim JM, "Atherosclerosis-related circulating microRNAs as a predictor of stroke recurrence", Transl Stroke Res, 6, pp.191~197 (2015)
- Jickling GC, "Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke", Neurology, 87, pp.2198~2205 (2016)
- Long J, "Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions", J Biol Chem, 285, pp.23457~23465 (2010)
- Pérez LM, "Metabolic rescue of obese adipose-derived stem cells by Lin28", Let7 pathway, 2013, pp.62, 2368~2379
- Frost RJ, "Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs", Proc Natl Acad Sci U S A, 108, pp.21075~21080 (2011)
- Kim J, "Association of muscle and visceral adipose tissues with the probability of Alzheimer’s disease in healthy subjects", Sci Rep, 9, pp.949~ (2019)
- Kim J, "18F-FDG PET", CT imaging factors that predict ischaemic stroke in cancer patients, 2016, pp.43, 2228~2235
- Van Bortel LM, "Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity", J Hypertens, 30, pp.445~448 (2012)
- Tanaka H, "Comparison between carotid-femoral and brachial-ankle pulse wave velocity as measures of arterial stiffness", J Hypertens, 27, pp.2022~2027 (2009)
- Taverner D, "Assessment of arterial stiffness variables in patients with rheumatoid arthritis : a mediation analysis", Sci Rep, 9, pp.4543~ (2019)
- Lee HY, "Aging and arterial stiffness", Circ J, 74, pp.2257~2262 (2010)
- Cavalcante JL, "Aortic stiffness : current understanding and future directions", J Am Coll Cardiol, 57, pp.1511~1522 (2011)
- Ito N, "Clinical usefulness and limitations of brachial-ankle pulse wave velocity in the evaluation of cardiovascular complications in hypertensive patients", Hypertens Res, 29, pp.989~995 (2006)
- Mitchell GF, "Arterial stiffness, pressure and flow pulsatility and brain structure and function : the age, gene", environment susceptibility--Reykjavik study, 2011, pp.134(Pt 11), 3398~3407
- Dart AM, "Pulse pressure--a review of mechanisms and clinical relevance", J Am Coll Cardiol, 37, pp.975~984 (2001)
- Kandula NR, "Association of 10-year and lifetime predicted cardiovascular disease risk with subclinical atherosclerosis in South Asians : findings from the Mediators of Atherosclerosis in South Asians Living in America(MASALA)study", J Am Heart Assoc, 3, pp.e001117~ (2014)
- Reinhart BJ, "The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans", Nature, 403, pp.901~906 (2000)
- Boyerinas B, "The role of let-7 in cell differentiation and cancer", Endocr Relat Cancer, 17, pp.F19~F36 (2010)
- Roush S, "The let-7 family of microRNAs", Trends Cell Biol, 18, pp.505~516 (2008)
- Brennan E, "Protective effect of let-7 miRNA family in regulating inflammation in diabetes-associated atherosclerosis", Diabetes, 66, pp.2266~2277 (2017)
- Satoh M, "Activated toll-like receptor 4 in monocytes is associated with heart failure after acute myocardial infarction", Int J Cardiol, 109, pp.226~234 (2006)
- Aubrey J, "Measurement of skeletal muscle radiation attenuation and basis of its biological variation", Acta Physiol(Oxf), 210, pp.489~497 (2014)
- Fiuza-Luces C, "Exercise benefits in cardiovascular disease : beyond attenuation of traditional risk factors", Nat Rev Cardiol, 15, pp.731~743 (2018)
- Madden KM, "Short-term aerobic exercise reduces arterial stiffness in older adults with type 2diabetes, hypertension, and hypercholesterolemia", Diabetes Care, 32, pp.1531~1535 (2009)
- Deiuliis JA, "MicroRNAs as regulators of metabolic disease: pathophysiologic significance and emerging role as biomarkers and therapeutics", Int J Obes(Lond), 40, pp.88~101 (2016)
- Fabbri E, "MicroRNA miR-93-5p regulates expression of IL-8 and VEGF in neuroblastoma SK-N-AS cells", Oncol Rep, 35, pp.2866~2872 (2016)
- Singh B, "MicroRNA-93regulates NRF2 expression and is associated with breast carcinogenesis", Carcinogenesis, 34, pp.1165~1172 (2013)
- He Y, "Up-regulated miR-93 contributes to coronary atherosclerosis pathogenesis through targeting ABCA1", Int J Clin Exp Med, 8, pp.674~681 (2015)
- Kim JM, "Analysis of microRNA signatures in ischemic stroke thrombus", J Neurointerv Surg, 14, pp.469~474 (2022)
- Luo X, "Plasma exosomal miR-450b-5p as a possible biomarker and therapeutic target for transient ischaemic attacks in rats", J Mol Neurosci, 69, pp.516~526 (2019)
- Li Y, "MiR-629-5p promotes the invasion of lung adenocarcinoma via increasing both tumor cell invasion and endothelial cell permeability", Oncogene, 39, pp.3473~3488 (2020)