Association between food consumption and serum aryl hydrocarbon receptor ligand activity among middle-aged Korean adults
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BACKGROUND/OBJECTIVES: The diet is an important route of exposure to endocrine- disrupting chemicals (EDCs). However, few studies have investigated the association between dietar y intake and EDC exposure levels among Koreans. In an earlier study, we showed that the bioactivity of serum ar yl hydrocarbon receptor ligands (AhRLs) could bea surrogate biomarker to indicate exposure to EDCs and that they inhibit mitochondrial function. We also found that the mitochondria-inhibiting substances (MIS) in serum ascertained by intracellular adenosine triphosphate (MIS-ATP) and reactive oxygen species (MIS-ROS) levels could be biomarkers of exposure to EDCs, as they showed a strong correlation with AhRL and the levels of EDCs in the blood. Here, we investigated the association between the consumption of specific foods and surrogate serum biomarkers for EDCs, namely AhRL, MIS-ATP, and MIS-ROS, among middle-aged Korean adults. SUBJECTS/METHODS: A total of 1,466 participants aged 45–76 yrs from the Ansung cohort of the Korean Genome and Epidemiology Study were included. Food consumption, including that of meat, fish, vegetables, and fruits, was measured using a semiquantitative food frequency questionnaire. RESULTS: Fish intake was positively associated with AhRL (β = 0.0035, P = 0.0166), whereas cruciferous vegetable intake was negatively associated with AhRL (β = −0.0007, P = 0.0488). Cruciferous vegetable intake was positively associated with the MIS-ATP levels (β = 0.0051, P = 0.0420). A higher intake of fish was significantly associated with an increased risk of high AhRL (tertile: odds ratio [OR], 1.49; 95% confidence inter vals (CIs), 1.08–2.06; P for trend = 0.0305). In addition, the second-highest tertile of cruciferous vegetable intake had lower odds of high AhRL than the lowest tertile (OR, 0.73; 95% CIs, 0.54–0.97), although no significant linear trend was obser ved. CONCLUSION: Consumption of different types of foods may be differentially associated with EDC exposure in middle-aged Korean adults.
Abstract
BACKGROUND/OBJECTIVES: The diet is an important route of exposure to endocrine- disrupting chemicals (EDCs). However, few studies have investigated the association between dietar y intake and EDC exposure levels among Koreans. In an earlier study, we showed that the bioactivity of serum ar yl hydrocarbon receptor ligands (AhRLs) could bea surrogate biomarker to indicate exposure to EDCs and that they inhibit mitochondrial function. We also found that the mitochondria-inhibiting substances (MIS) in serum ascertained by intracellular adenosine triphosphate (MIS-ATP) and reactive oxygen species (MIS-ROS) levels could be biomarkers of exposure to EDCs, as they showed a strong correlation with AhRL and the levels of EDCs in the blood. Here, we investigated the association between the consumption of specific foods and surrogate serum biomarkers for EDCs, namely AhRL, MIS-ATP, and MIS-ROS, among middle-aged Korean adults. SUBJECTS/METHODS: A total of 1,466 participants aged 45–76 yrs from the Ansung cohort of the Korean Genome and Epidemiology Study were included. Food consumption, including that of meat, fish, vegetables, and fruits, was measured using a semiquantitative food frequency questionnaire. RESULTS: Fish intake was positively associated with AhRL (β = 0.0035, P = 0.0166), whereas cruciferous vegetable intake was negatively associated with AhRL (β = −0.0007, P = 0.0488). Cruciferous vegetable intake was positively associated with the MIS-ATP levels (β = 0.0051, P = 0.0420). A higher intake of fish was significantly associated with an increased risk of high AhRL (tertile: odds ratio [OR], 1.49; 95% confidence inter vals (CIs), 1.08–2.06; P for trend = 0.0305). In addition, the second-highest tertile of cruciferous vegetable intake had lower odds of high AhRL than the lowest tertile (OR, 0.73; 95% CIs, 0.54–0.97), although no significant linear trend was obser ved. CONCLUSION: Consumption of different types of foods may be differentially associated with EDC exposure in middle-aged Korean adults.
참고문헌 (38)
- Song Y, "Endocrine-disrupting chemicals, risk of type 2 diabetes, and diabetes-related metabolic traits : a systematic review and meta-analysis", J Diabetes, 8, pp.516~532 (2016)
- Heindel JJ, "Metabolism disrupting chemicals and metabolic disorders", Reprod Toxicol, 68, pp.3~33 (2017)
- Le Magueresse-Battistoni B, "Environmental pollutants and metabolic disorders: the multi-exposure scenario of life", Front Endocrinol(Lausanne), 9, pp.582~ (2018)
- Ribeiro CM, "Exposure to endocrine-disrupting chemicals and anthropometric measures of obesity : a systematic review and meta-analysis", BMJ Open, 10, pp.e033509~ (2020)
- Windal I, "Chemically activated luciferase gene expression(CALUX)cell bioassay analysis for the estimation of dioxin-like activity : critical parameters of the CALUX procedure that impact assay results", Environ Sci Technol, 39, pp.7357~7364 (2005)
- Murray IA, "Aryl hydrocarbon receptor ligands in cancer : friend and foe", Nat Rev Cancer, 14, pp.801~814 (2014)
- Park WH, "Novel cell-based assay reveals associations of circulating serum AhR-ligands with metabolic syndrome and mitochondrial dysfunction", Biofactors, 39, pp.494~504 (2013)
- Lee HK, "Serum biomarkers from cell-based assays for AhRL and MIS strongly predicted the future development of diabetes in a large community-based prospective study in Korea", Sci Rep, 10, pp.6339~ (2020)
- Park WH, "Relationships between serum-induced AhR bioactivity or mitochondrial inhibition and circulating polychlorinated biphenyls(PCBs)", Sci Rep, 7, pp.9383~ (2017)
- Park S, "Association of aryl hydrocarbon receptor transactivating activity, a potential biomarker for persistent organic pollutants, with the risk of gestational diabetes mellitus", Sci Rep, 11, pp.3185~ (2021)
- Guo W, "Persistent organic pollutants in food : contamination sources, health effects and detection methods", Int J Environ Res Public Health, 16, pp.4361~ (2019)
- Mukherjee R, "Endocrine disruptors–‘food’ for thought", Proc Zool Soc, 74, pp.432~442 (2021)
- Li Y, "Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation", Cell, 147, pp.629~640 (2011)
- Hooper LV, "You AhR what you eat : linking diet and immunity", Cell, 147, pp.489~491 (2011)
- Donovan MG, "Aryl hydrocarbon receptor diet and breast cancer risk", Yale J Biol Med, 91, pp.105~127 (2018)
- Kim Y, "Cohort profile : the Korean Genome and Epidemiology Study(KoGES)consortium", Int J Epidemiol, 46, pp.1350~ (2017)
- The Korean Nutrition Society, "Recommended Dietary Allowances for Koreans" (2000), Korean Nutrition Society
- Kim JT, "Metabolic syndrome and the environmental pollutants from mitochondrial perspectives", Rev Endocr Metab Disord, 15, pp.253~262 (2014)
- Korashy HM, "Differential effects of mercury, lead and copper on the constitutive and inducible expression of aryl hydrocarbon receptor(AHR)-regulated genes in cultured hepatoma Hepa 1c1c7 cells", Toxicology, 201, pp.153~172 (2004)
- Amara IE, "Effect of mercury on aryl hydrocarbon receptor-regulated genes in the extrahepatic tissues of C57BL", 6 mice, 2012, pp.50, 2325~2334
- Kulas J, "Aryl hydrocarbon receptor is involved in the proinflammatory cytokine response to cadmium", Biomed Environ Sci, 34, pp.192~202 (2021)
- De Juan A, "Modulation of immune responses by nutritional ligands of aryl hydrocarbon receptor", Front Immunol, 12, pp.645168~ (2021)
- Rimm EB, "American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health Seafood long-chain n-3 polyunsaturated fatty acids and cardiovascular disease: a science advisory from the American Heart Association", Circulation, 138, pp.e35~47 (2018)
- Dietary Reference Intakes for Koreans 2020, "Ministry of Health and Welfare (KR)", ~ (2020)
- Dietary Guidelines for Americans; 2020–2025, "US Department of Agriculture", US Department of Agriculture, ~ (2020)
- Schecter A, "Polybrominated diphenyl ether(PBDE)levels in an expanded market basket survey of U. S. food and estimated PBDE dietary intake by age and sex", Environ Health Perspect, 114, pp.1515~1520 (2006)
- "Advice about eating fish" (2021)[URL]
- Li A, "Persistent and toxic chemical pollutants in fish consumed by Asians in Chicago, United States", Sci Total Environ, 811, pp.152214~ (2022)
- Pironti C, "Endocrine-disrupting compounds : an overview on their occurrence in the aquatic environment and human exposure", Water, 13, pp.1347~ (2021)
- Jeong Y, "Accumulation and time trends(2003-2015)of persistent organic pollutants(POPs)in blubber of finless porpoises(Neophocaena asiaeorientalis)from Korean coastal waters", J Hazard Mater, 385, pp.121598~ (2020)
- Riaz R, "Persistent organic pollutants(POPs)in fish species from different lakes of the lesser Himalayan region(LHR), Pakistan : the influence of proximal sources in distribution of POPs", Sci Total Environ, 760, pp.143351~ (2021)
- Awata H, "Association of dietary intake and biomarker levels of arsenic, cadmium, lead, and mercury among Asian populations in the United States : NHANES 2011–2012", Environ Health Perspect, 125, pp.314~323 (2017)
- Terry AL, "Seafood consumption in the United States, 2013-2016", NCHS Data Brief, 321, pp.1~8 (2018)
- Jeon HL, "First nationwide exposure profile of major persistent organic pollutants among Korean adults and their determinants : Korean National Environmental Health Survey Cycle 3(2015-2017)", Int J Hyg Environ Health, 236, pp.113779~ (2021)
- Kodavanti PR, "Reference Module in Biomedical Science" (2014), Elsevier
- Vaccher V, "Levels of persistent organic pollutants(POPs)in foods from the first regional Sub-Saharan Africa Total Diet Study", Environ Int, 135, pp.105413~ (2020)
- Domingo JL, "Concentrations of environmental organic contaminants in meat and meat products and human dietary exposure : a review", Food Chem Toxicol, 107, pp.20~26 (2017)
- Ha K, "Inadequate fat or carbohydrate intake was associated with an increased incidence of type 2 diabetes mellitus in Korean adults : a 12-year community-based prospective cohort study", Diabetes Res Clin Pract, 148, pp.254~261 (2019)