한국 성인의 혈청 잔류성 유기오염물질 농도와 연령 및 체질량지수와의 관련성
Association of Persistent Organic Pollutants (POPs) with Age and Body Mass Index in Korean Adults
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Objectives: Persistent organic pollutants (POPs) are known to be the detrimental chemicals in the body, even at lowlevels, and are stored in adipose tissue. Recently, POPs have been reported to be associated with chronic diseases,including cancer and cardiovascular disease, and aging and obesity are reported as common factors in chronicdisease. However, there have been only a few studies on the associations of POPs with age and body mass index(BMI) in Korea. Therefore, we analyzed the associations of serum POPs levels with age and BMI in Korea. Methods: This cross-sectional study includes 444 subjects (253 men and 191 women) from the Korean CancerPrevention Study-II (2004-2011). Serum levels of 33 polychlorinated biphenyls (PCBs) and 19 organochlorinepesticides (OCPs) were measured by a gas chromatographer (Agilent 6890) coupled to high resolution massspectrometer (JEOL JMS-800D). Results: Concentrations of PCB 153 (men: 12.26 ng/g lipid, women: 10.50 ng/g lipid) and p,p'-DDE (men:94.66 ng/g lipid, women: 96.66 ng/g lipid) were the highest among serum PCBs and OCPs, respectively. PCBsand OCPs were significantly positively correlated with age in both sexes. After adjustment for age, non-dioxinlike PCBs were significantly negatively correlated with body mass in women. However, cis-heptachlor epoxidewas significantly positively correlated with body mass index in both sexes. When analyzed by sex, strongerassociations were shown between POPs and age in men and POPs and BMI in women. Conclusion: These results may provide baseline data for the study of POPs and for the health management field in Korea.
Abstract
Objectives: Persistent organic pollutants (POPs) are known to be the detrimental chemicals in the body, even at lowlevels, and are stored in adipose tissue. Recently, POPs have been reported to be associated with chronic diseases,including cancer and cardiovascular disease, and aging and obesity are reported as common factors in chronicdisease. However, there have been only a few studies on the associations of POPs with age and body mass index(BMI) in Korea. Therefore, we analyzed the associations of serum POPs levels with age and BMI in Korea. Methods: This cross-sectional study includes 444 subjects (253 men and 191 women) from the Korean CancerPrevention Study-II (2004-2011). Serum levels of 33 polychlorinated biphenyls (PCBs) and 19 organochlorinepesticides (OCPs) were measured by a gas chromatographer (Agilent 6890) coupled to high resolution massspectrometer (JEOL JMS-800D). Results: Concentrations of PCB 153 (men: 12.26 ng/g lipid, women: 10.50 ng/g lipid) and p,p'-DDE (men:94.66 ng/g lipid, women: 96.66 ng/g lipid) were the highest among serum PCBs and OCPs, respectively. PCBsand OCPs were significantly positively correlated with age in both sexes. After adjustment for age, non-dioxinlike PCBs were significantly negatively correlated with body mass in women. However, cis-heptachlor epoxidewas significantly positively correlated with body mass index in both sexes. When analyzed by sex, strongerassociations were shown between POPs and age in men and POPs and BMI in women. Conclusion: These results may provide baseline data for the study of POPs and for the health management field in Korea.
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