머위(Petasites japonicus) 추출물의 항산화와 항암활성 효과
The Antioxidant and Anticancer Effects of Butterbur (Petasites japonicus) Extracts
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초록
The antioxidant activities of the extracts of butterbur (Petasites japonicus) derived from different extraction methods were investigated. SOD (superoxide dismutase)-like activity differed according to the extraction solvents, showing a greater antioxidant effect with ethanol solvent than that of water. Ethanol extracts of butterbur leaves showed higher SOD-like activity of 96.7% than those of water extracts. The contents of polyphenolic compounds were higher in water extracts than those in ethanol extracts. The highest content of polyphenolic compounds was 223mg/g dry weight for butterbur leaves. EDA of butterbur roots was 61.5% in the water extract and EDA in butterbur leaves was 34.9% in the ethanol extract. The anticancer effects with the extracts of butterbur were experimented by fractionations with different solvents. 41.9% of the growth of stomach cancer cells, SNU-719, were inhibited and also 72.7% of the growth of liver cancer cells, Hep3B, were inhibited by the butanol fractions of butterbur, while not affecting the growth of normal cell, DC 2.4.
Abstract
The antioxidant activities of the extracts of butterbur (Petasites japonicus) derived from different extraction methods were investigated. SOD (superoxide dismutase)-like activity differed according to the extraction solvents, showing a greater antioxidant effect with ethanol solvent than that of water. Ethanol extracts of butterbur leaves showed higher SOD-like activity of 96.7% than those of water extracts. The contents of polyphenolic compounds were higher in water extracts than those in ethanol extracts. The highest content of polyphenolic compounds was 223mg/g dry weight for butterbur leaves. EDA of butterbur roots was 61.5% in the water extract and EDA in butterbur leaves was 34.9% in the ethanol extract. The anticancer effects with the extracts of butterbur were experimented by fractionations with different solvents. 41.9% of the growth of stomach cancer cells, SNU-719, were inhibited and also 72.7% of the growth of liver cancer cells, Hep3B, were inhibited by the butanol fractions of butterbur, while not affecting the growth of normal cell, DC 2.4.
참고문헌 (18)
- Blois,M.S., "Antioxidant determination by the use of a stable free radical", Nature, 26, pp.1198~1202 (1958)
- Brattstrom,A., "A newly developed extract (Ze 339) from butterbur (Petasites hybridus L.) is clinically efficient in allergic rhinitis (hay fever)", Phytomedicine, 10, pp.50~52 (2003)
- 이명렬, "머위 (Petasites japonicus S. et Z. Max.)의 이화학적 성분", 한국식품저장유통학회지, 13(5), pp.661~667 (2006), 한국식품저장유통학회
- Cho,S.Y., "Screening for antioxidant activity of edible plants", J. Korean Soc. Food Sci. Nutr, 30(1), pp.133~137 (2001)
- 최옥범, "머위(Petasites japonicum) 추출물의 항알레르기 효과", 한국식품영양학회지, 15(4), pp.382~385 (2002), 한국식품영양학회
- Jee,Y.H., "Pathological changes on rats and mice fed with Petasites japonicus Maxim", Korean J. Vet. Res, 36(2), pp.417~428 (1996)
- Kikuchi,M., "Studies on the constituents of the flower stalk of Petasites japonicus Maxim VII. on the components of the volatile oil", Yakugaku Zasshi, 93, pp.123~126 (1973)
- Lee,C.H., "An apoptosis regulator isolated from Petasites japonicus", Korean J. Food Sci. Technol, 32(2), pp.448~453 (2000)
- 이기영, "연잎 에탄올 추출물의 항산화 효과", 한국식품영양과학회지, 35(2), pp.182~186 (2006), 한국식품영양과학회지
- 이준설, "고구마 끝순 추출물의 항산화 및 생리활성", 한국작물학회지, 52(2), pp.228~238 (2007), 한국작물학회
- Marklund,S., "Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase", Eur. J. Biochem, 47, pp.469~474 (1974)
- 오상희, "머위(Petasites japonicus Maxim) 첨가 식이가 마우스 혈장 지질 수준 및 항산화 지표에 미치는 영향", 동아시아식생활학회지, 16(4), pp.399~407 (2006), 동아시아식생활학회
- Slinkard,K., "Total phenol analysis: automation and comparison with manual method", Am. J. Ecol. Vitic, 28(1), pp.49~56 (1977)
- Wang,G.J., "Calcium channel blockade in vasscular smooth muscle cell is major hypotensive mechanism of S-petasin, a hypotensive sequiterpene from Petasites formosanus", J. Pharmacol. Exp. Ther, 297, pp.240~246 (2001)
- Yaoita,Y., "Eremopetasidione a Norsesquiterpenoid form the rhizomes of Petasites japonicus", Phytochem, 37, pp.1765~1766 (1994)
- Yaoita,Y., "Petasiphenone a phenolic compound form rhizomes of Petasites Japonicus", Phytochem, 37, pp.1773~1774 (1994)
- Yaoita,Y., "Structures of six new eremophilenolides from the rhizomes of Petasites Japonicus", Pharm. Bull, 42, pp.1944~1947 (1994)
- Yoo,J.S., "Studies on the antioxidant effects of Carthami Flos extract", J. Korean Oriental Med, 28(1), pp.137~147 (2007)