Aging Index using Photoplethysmography for a Healthcare Device: Comparison with Brachial-Ankle Pulse Wave Velocity
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Objectives: Recent studies have emphasized the potential information embedded in peripheral fingertip photoplethysmogram(PPG) signals for the assessment of arterial wall stiffening during aging. For the discrimination of arterial stiffness withage, the brachial-ankle pulse wave velocity (baPWV) has been widely used in clinical applications. The second derivative ofthe PPG (acceleration photoplethysmogram [APG]) has been reported to correlate with the presence of atherosclerotic disorders. In this study, we investigated the association among age, the baPWV, and the APG and found a new aging index reflectingarterial stiffness for a healthcare device. Methods: The APG and the baPWV were simultaneously applied to assess theaccuracy of the APG in measuring arterial stiffness in association with age. A preamplifier and motion artifact removal algorithmwere newly developed to obtain a high quality PPG signal. In total, 168 subjects with a mean ± SD age of 58.1 ± 12.6years were followed for two months to obtain a set of complete data using baPWV and APG analysis. Results: The baPWVand the B ratio of the APG indices were correlated significantly with age (r = 0.6685, p < 0.0001 and r = –0.4025, p < 0.0001,respectively). A regression analysis revealed that the c and d peaks were independent of age (r = –0.3553, p < 0.0001 and r =–0.3191, p < 0.0001, respectively). Conclusions: We determined the B ratio, which represents an improved aging index andsuggest that the APG may provide qualitatively similar information for arterial stiffness.
Abstract
Objectives: Recent studies have emphasized the potential information embedded in peripheral fingertip photoplethysmogram(PPG) signals for the assessment of arterial wall stiffening during aging. For the discrimination of arterial stiffness withage, the brachial-ankle pulse wave velocity (baPWV) has been widely used in clinical applications. The second derivative ofthe PPG (acceleration photoplethysmogram [APG]) has been reported to correlate with the presence of atherosclerotic disorders. In this study, we investigated the association among age, the baPWV, and the APG and found a new aging index reflectingarterial stiffness for a healthcare device. Methods: The APG and the baPWV were simultaneously applied to assess theaccuracy of the APG in measuring arterial stiffness in association with age. A preamplifier and motion artifact removal algorithmwere newly developed to obtain a high quality PPG signal. In total, 168 subjects with a mean ± SD age of 58.1 ± 12.6years were followed for two months to obtain a set of complete data using baPWV and APG analysis. Results: The baPWVand the B ratio of the APG indices were correlated significantly with age (r = 0.6685, p < 0.0001 and r = –0.4025, p < 0.0001,respectively). A regression analysis revealed that the c and d peaks were independent of age (r = –0.3553, p < 0.0001 and r =–0.3191, p < 0.0001, respectively). Conclusions: We determined the B ratio, which represents an improved aging index andsuggest that the APG may provide qualitatively similar information for arterial stiffness.
참고문헌 (9)
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