자살 시도와 자살 사고 간 반응억제 사건유발전위 비교 연구
Comparison of the Response Inhibitory Event Related Potential between Suicide Attempt and Ideation
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Objective : There have been limited scientific studies differentiating those who attempt suicide f rom those who think about suicide but do not attempt suicide. Altered event-related potential (ERP) performance, such as GoNogo ERP has been regarded as the neurocognitive processes associated with behavioral inhibition and poor impulse control. The purpose of this study was to investigate the association between Nogo ERP and suicide attempt. Methods : A total of 63 participants (33 participants with suicide ideation and 30 with suicide attempt) were recruited, and performed GoNogo tasks during the electroencephalogram measurement. Depression, anxiety, emotional regulation and impulsivity were evaluated by self-rating scales. The clinical measures and Nogo P3 component were compared between the groups. The correlational analyse was conducted to evaluate the relationship between the clinical characteristics and the Nogo P3 component. Results : Participants with suicide attempt significantly decreased the Nogo P3 amplitudes at the frontal- central electrode than participants with suicide ideation (p=0.004, FDR adjusted p=0.032). In the correlation analysis, the Nogo P3 amplitude at frontal-central electrode was correlated with the total score of the Barrett impulsivity scale (r=-0.383, p=0.002), attentional impulsivity (r=-0.365, p=0.003) and motor impulsivity (r=-0.389, p=0.002) subscales of the Barrett impulsivity scale. Conclusion : These findings suggest that the decreased Nogo P3 amplitude may be one of the candidates of biological marker for poor impulse control in those who attempt suicide. (Anxiety and Mood 2020;16(1):41-48)
Abstract
Objective : There have been limited scientific studies differentiating those who attempt suicide f rom those who think about suicide but do not attempt suicide. Altered event-related potential (ERP) performance, such as GoNogo ERP has been regarded as the neurocognitive processes associated with behavioral inhibition and poor impulse control. The purpose of this study was to investigate the association between Nogo ERP and suicide attempt. Methods : A total of 63 participants (33 participants with suicide ideation and 30 with suicide attempt) were recruited, and performed GoNogo tasks during the electroencephalogram measurement. Depression, anxiety, emotional regulation and impulsivity were evaluated by self-rating scales. The clinical measures and Nogo P3 component were compared between the groups. The correlational analyse was conducted to evaluate the relationship between the clinical characteristics and the Nogo P3 component. Results : Participants with suicide attempt significantly decreased the Nogo P3 amplitudes at the frontal- central electrode than participants with suicide ideation (p=0.004, FDR adjusted p=0.032). In the correlation analysis, the Nogo P3 amplitude at frontal-central electrode was correlated with the total score of the Barrett impulsivity scale (r=-0.383, p=0.002), attentional impulsivity (r=-0.365, p=0.003) and motor impulsivity (r=-0.389, p=0.002) subscales of the Barrett impulsivity scale. Conclusion : These findings suggest that the decreased Nogo P3 amplitude may be one of the candidates of biological marker for poor impulse control in those who attempt suicide. (Anxiety and Mood 2020;16(1):41-48)
참고문헌 (29)
- Korea S, "Statistics Korea (homepage on the internet). Causes of death statistics in Korea", ~ (2013)
- Ernst C, "Suicide neurobiology", Prog Neurobiol, 89, pp.315~333 (2009)
- Albanese BJ, "Impaired conflict detection differentiates suicide attempters from ideating nonattempters : evidence from event-related potentials", Biol Psychiatry Cogn Neurosci Neuroimaging, 4, pp.902~912 (2019)
- 김지연, "치명도가 높은 자살기도자의 심리적, 행동적 특성에 대한 후향적 회상연구", 신경정신의학, 54(4), pp.435~443 (2015), 대한신경정신의학회[DOI]
- Sur S, "Event-related potential: an overview", Ind Psychiatry J, 18, pp.70~73 (2009)
- Jollant F, "The suicidal mind and brain : a review of neuropsychological and neuroimaging studies", The World Journal of Biological Psychiatry, 12, pp.319~339 (2011)
- Van Orden KA, "Using the interpersonal theory of suicide to inform interpersonal psychotherapy with a suicidal older adult", Clin Case Stud, 11, pp.333~347 (2012)
- Marco M, "The influence of planning and response inhibition on cognitive functioning of non-psychotic unipolar depressed suicide attempters", Europe’s Journal of Psychology, pp.13~ (2017)
- Saffer BY, "Do neurocognitive abilities distinguish suicide attempters from suicide ideators? A systematic review of an emerging research area", Clinical Psychology : Science and Practice, 25, pp.e12227~ (2018)
- Messerotti Benvenuti S, "Influence of impulsiveness on emotional modulation of response inhibition : an ERP study", Clin Neurophysiol, 126, pp.1915~1925 (2015)
- Brown MR, "fMRI investigation of response inhibition, emotion, impulsivity, and clinical high-risk behavior in adolescents", Front Syst Neurosci, 9, pp.124~ (2015)
- Smith JL, "Motor and non-motor inhibition in the Go", NoGo task : an ERP and fMRI study, 2013, pp.87, 244~253
- Bruin KJ, "Response priming in a go", nogo task : do we have to explain the go, Clin Neurophysiol, pp.2001, 112[DOI]
- Nieuwenhuis S, "Electrophysiological correlates of anterior cingulate function in a go", no-go task : effects of response conflict and trial type frequency, 2003, pp.3, 17~26
- Bohne A, "Motor inhibition in trichotillomania and obsessive-compulsive disorder", J Psychiatr Res, 42, pp.141~150 (2008)
- Buchmann J, "Intelligence moderates impulsivity and attention in ADHD children: an ERP study using a go", nogo paradigm, 2011, pp.12(Suppl 1), 35~39
- Guan M, "Impaired response inhibition in juvenile delinquents with antisocial personality characteristics : A preliminary ERP study in a Go", Nogo task, 2015, pp.603, 1~5
- Beck AT, "An inventory for measuring depression", Arch Gen Psychiatry, 4, pp.561~571 (1961)
- Beck AT, "An inventory for measuring clinical anxiety : psychometric properties", J Consult Clin Psychol, 56, pp.893~897 (1988)
- Gratz KL, "Multidimensional assessment of emotion regulation and dysregulation : Development, factor structure, and initial validation of the Difficulties in Emotion Regulation Scale", Journal of Psychopathology and Behavioral Assessment, 26, pp.41~54 (2004)
- Patton JH, "Factor structure of the Barratt impulsiveness scale", J Clin Psychol, 51, pp.768~774 (1995)
- Hartmann L, "Enhancing frontal top-down inhibitory control with Go", NoGo training, 2015, ~
- Liu Q, "Effects of 72hours total sleep deprivation on male astronauts"executive functions and emotion", Compr Psychiatry, 61, pp.28~35 (2015)
- Reynolds B, "Dimensions of impulsive behavior in adolescents : laboratory behavioral assessments", Exp Clin Psychopharmacol, 16, pp.124~131 (2008)
- Corruble E, "Understanding impulsivity in severe depression? A psychometrical contribution", Prog Neuropsychopharmacol Biol Psychiatry, 27, pp.829~833 (2003)
- Nguyen AT, "N2 and P3 modulation during partial inhibition in a modified go", nogo task, 2016, pp.107, 63~71
- Smith JL, "Movement-related potentials in the Go", NoGo task : the P3 reflects both cognitive and motor inhibition, 2008, pp.119, 704~714
- Hong X, "Segregating top-down selective attention from response inhibition in a spatial cueing Go", NoGo task : an ERP and source localization study, 2017, pp.7, 9662~
- Kim JS, "Auditory evoked potential could reflect emotional sensitivity and impulsivity", Sci Rep, 6, pp.37683~ (2016)