본문 바로가기
KERD
논문KCI 등재

The Relationship Between Response-Inhibitory Event-Related Potentials and Symptoms of Attention-Deficit/Hyperactivity Disorder in Adult Patients with Major Depressive Disorder

2

조회

0

다운로드

2

인용

0

참고문헌

키워드

주제분류정신과학

초록

Objective Attention-deficit and poor impulse control have frequently been observed in major depressive disorder (MDD) and attention-deficit and hyperactivity disorder (ADHD). Altered event-related potential (ERP) performance, such as GoNogo tasks, has been regarded as a neurocognitive process associated with attention and behavioral inhibition. The aim of this study was to investigate the association between Nogo ERP and adult ADHD in MDD.Methods A total of 64 participants with MDD (32 comorbid with ADHD) and 32 healthy controls aged 19–45 years were recruited; they performed GoNogo paradigms during electroencephalogram measurement. Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and the Adult ADHD Self-Report Scale (ASRS) were evaluated. Clinical measures and GoNogo ERP were compared between three groups: depression with ADHD, depression without ADHD, and healthy controls.Results MDD subjects with ADHD showed significantly decreased Nogo P3 amplitude at frontal electrode, compared with those without ADHD and healthy controls. MDD subjects with ADHD showed significantly longer Nogo N2 latency at frontal and frontocentral electrodes, compared with those without ADHD and healthy controls. In MDD subjects with ADHD, the Nogo P3 amplitude at the frontal electrode was negatively correlated with the ASRS score and inattention. The Nogo N2 latency at the frontal electrode was positively correlated with false alarm rate.Conclusion The decreased Nogo P3 amplitude in the frontal area might be a potential biological marker for inattention in depressed patients with ADHD.

Abstract

Objective Attention-deficit and poor impulse control have frequently been observed in major depressive disorder (MDD) and attention-deficit and hyperactivity disorder (ADHD). Altered event-related potential (ERP) performance, such as GoNogo tasks, has been regarded as a neurocognitive process associated with attention and behavioral inhibition. The aim of this study was to investigate the association between Nogo ERP and adult ADHD in MDD.Methods A total of 64 participants with MDD (32 comorbid with ADHD) and 32 healthy controls aged 19–45 years were recruited; they performed GoNogo paradigms during electroencephalogram measurement. Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and the Adult ADHD Self-Report Scale (ASRS) were evaluated. Clinical measures and GoNogo ERP were compared between three groups: depression with ADHD, depression without ADHD, and healthy controls.Results MDD subjects with ADHD showed significantly decreased Nogo P3 amplitude at frontal electrode, compared with those without ADHD and healthy controls. MDD subjects with ADHD showed significantly longer Nogo N2 latency at frontal and frontocentral electrodes, compared with those without ADHD and healthy controls. In MDD subjects with ADHD, the Nogo P3 amplitude at the frontal electrode was negatively correlated with the ASRS score and inattention. The Nogo N2 latency at the frontal electrode was positively correlated with false alarm rate.Conclusion The decreased Nogo P3 amplitude in the frontal area might be a potential biological marker for inattention in depressed patients with ADHD.

참고문헌 (61)

  1. Min KJ, "Depressive Disorder", pp.279~297 (2017), iMiS Company Press
  2. Purcell R, "Neuropsychological function in young patients with unipolar major depression", Psychol Med, 27, pp.1277~1285 (1997)
  3. Paelecke-Habermann Y, "Attention and executive functions in remitted major depression patients", J Affect Disord, 89, pp.125~135 (2005)
  4. Austin MP, "Cognitive function in depression: a distinct pattern of frontal impairment in melancholia?", Psychol Med, 29, pp.73~85 (1999)
  5. Sweeney JA, "Neuropsychologic impairments in bipolar and unipolar mood disorders on the CANTAB neurocognitive battery", Biol Psychiatry, 48, pp.674~684 (2000)
  6. Ruchsow M, "Error processing in major depressive disorder : evidence from eventrelated potentials", J Psychiatr Res, 40, pp.37~46 (2006)
  7. Chiu PH, "Neural evidence for enhanced error detection in major depressive disorder", Am J Psychiatry, 164, pp.608~616 (2007)
  8. Barkley RA, "The executive functions and self-regulation : an evolutionary neuropsychological perspective", Neuropsychol Rev, 11, pp.1~29 (2001)
  9. Volkow ND, "Adult attention deficit–hyperactivity disorder", N Engl J Med, 369, pp.1935~1944 (2013)
  10. Kim JS, "The relationship between auditory evoked potentials and symptoms of attention-deficit", hyperactivity disorder in adult patients with major depressive disorder, 2019, pp.142, 50~56
  11. Barkley RA, "Behavioral inhibition, sustained attention, and executive functions : constructing a unifying theory of ADHD", Psychol Bull, 121, pp.65~ (1997)
  12. Di Nicola M, "Adult attention-deficit", hyperactivity disorder in major depressed and bipolar subjects : role of personality traits and clinical implications, 2014, pp.264, 391~400
  13. Bond DJ, "The Canadian Network for Mood and Anxiety Treatments(CANMAT)task force recommendations for the management of patients with mood disorders and comorbid attention-deficit", hyperactivity disorder, 2012, pp.24, 23~37
  14. Kessler RC, "The prevalence and correlates of adult ADHD in the United States : results from the National Comorbidity Survey Replication", Am J Psychiatry, 163, pp.716~723 (2006)
  15. Biederman J, "Patterns of psychiatric comorbidity, cognition, and psychosocial functioning in adults with attention deficit hyperactivity disorder", Am J Psychiatry, 150, pp.1792~1798 (1993)
  16. Kooij J, "Efficacy and safety of methylphenidate in 45 adults with attention-deficit", hyperactivity disorder. A randomized placebo-controlled doubleblind cross-over trial, 2004, pp.34, 973~982
  17. Spencer T, "A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit", hyperactivity disorder, 2005, pp.57, 456~463
  18. Hyperactivity Disorder, "Comorbid Conditions in Child and Adolescent Patients Diagnosed with Attention Deficit", pp.2015, Yüce M
  19. Sobanski E, "Psychiatric comorbidity and functional impairment in a clinically referred sample of adults with attention-deficit", hyperactivity disorder(ADHD), 2007, pp.257, 371~377
  20. Biederman J, "New insights into the comorbidity between ADHD and major depression in adolescent and young adult females", J Am Acad Child Adolese Psychiatry, 47, pp.426~434 (2008)
  21. Fischer AG, "The role of comorbid major depressive disorder in the clinical presentation of adult ADHD", J Psychiatr Res, 41, pp.991~996 (2007)
  22. Secnik K, "Comorbidities and costs of adult patients diagnosed with attention-deficit hyperactivity disorder", Pharmacoeconomics, 23, pp.93~102 (2005)
  23. McIntosh D, "Adult ADHD and comorbid depression : a consensus-derived diagnostic algorithm for ADHD", Neuropsychiatr Dis Treat, 5, pp.137~150 (2009)
  24. Bokura H, "Electrophysiological correlates for response inhibition in a Go", NoGo task, 2001, pp.112, 2224~2232
  25. Patel SH, "Characterization of N200 and P300 : selected studies of the event-related potential", Int J Med Sci, 2, pp.147~154 (2005)
  26. Downes M, "Event-related potential measures of executive functioning from preschool to adolescence", Dev Med Child Neurol, 59, pp.581~590 (2017)
  27. Enriquez-Geppert S, "Conflict and inhibition differentially affect the N200", P300 complex in a combined go, Neuroimage, pp.2010, 51[DOI]
  28. Dimoska A, "The auditory-evoked N2 and P3components in the stop-signal task: indices of inhibition, responseconflict or error-detection?", Brain Cogn, 62, pp.98~112 (2006)
  29. Bruin K, "Response priming in a go", nogo task: do we have to explain the go, Clin Neurophysiol, pp.2001, 112[DOI]
  30. Zhang BW, "The effect of aging in inhibitory control of major depressive disorder revealed by event-related potentials", Front Hum Neurosci, 10, pp.116~ (2016)
  31. Ruchsow M, "Electrophysiological evidence for reduced inhibitory control in depressed patients in partial remission : a Go", Nogo study, 2008, pp.68, 209~218
  32. Zhang BW, "Electrophysiological activity underlying inhibitory control processes in late-life depression : a Go", Nogo study, 2007, pp.419, 225~230
  33. Kaiser S, "Executive control deficit in depression : event-related potentials in a Go", Nogo task, 2003, pp.122, 169~184
  34. Prox V, "Attentional processing in adults with ADHD as reflected by event-related potentials", Neurosci Lett, 419, pp.236~241 (2007)
  35. Wiersema R, "State regulation in adult ADHD : an event-related potential study", J Clin Exp Neuropsychol, 28, pp.1113~1126 (2006)
  36. Fallgatter AJ, "Altered response control and anterior cingulate function in attention-deficit", hyperactivity disorder boys, 2004, pp.115, 973~981
  37. Woltering S, "Neurophysiological differences in inhibitory control between adults with ADHD and their peers", Neuropsychologia, 51, pp.1888~1895 (2013)
  38. Gow RV, "Abnormal centroparietal ERP response in predominantly medication-naive adolescent boys with ADHD during both response inhibition and execution", J Clin Neurophysiol, 29, pp.181~189 (2012)
  39. Wild-Wall N, "Neural activity associated with executive functions in adolescents with attention-deficit", hyperactivity disorder(ADHD), 2009, pp.74, 19~27
  40. Broyd SJ, "The effect of methylphenidate on response inhibition and the event-related potential of children with attention deficit", hyperactivity disorder, 2005, pp.58, 47~58
  41. Pliszka SR, "Inhibitory control in children with attention-deficit", hyperactivity disorder : event-related potentials identify the processing component and timing of an impaired right-frontal response-inhibition mechanism, 2000, pp.48, 238~246
  42. Smith JL, "Inhibitory processing during the Go", NoGo task : an ERP analysis of children with attention-deficit, Clin Neurophysiol, pp.2004, 115[DOI]
  43. Jon DI, "Validity and reliability of the Korean version of the Mood Disorder Questionnaire", Compr Psychiatry, 50, pp.286~291 (2009)
  44. 임선영, "한국판 벡 우울 척도 2판의 타당화 연구", 대한불안의학회지, 7(1), pp.48~53 (2011), 대한불안의학회
  45. Kim J, "A standardization study of state-trait anxiety inventory in Korea", New Med J, 21, pp.1223~1229 (1978)
  46. Adler LA, "Validity of pilot Adult ADHD Self-Report Scale(ASRS)to rate adult ADHD symptoms", Ann Clin Psychiatry, 18, pp.145~148 (2006)
  47. 김설기, "Deficits in Verbal Working Memory among College Students with Attention- Deficit", Hyperactivity Disorder Traits: An Event-related Potential Study, 2016, pp.14(1), 64~73[DOI]
  48. Kim JS, "Auditory evoked potential could reflect emotional sensitivity and impulsivity", Sci Rep, 6, pp.37683~ (2016)
  49. Haukoos JS, "Advanced statistics: bootstrapping confidence intervals for statistics with “difficult” distributions", Acad Emerg Med, 12, pp.360~365 (2005)
  50. Ruscio J, "Constructing confidence intervals for Spearman’s rank correlation with ordinal data : a simulation study comparing analytic and bootstrap methods", J Mod Appl Stat Methods, 7, pp.416~434 (2008)
  51. Pernet CR, "Robust correlation analyses : false positive and power validation using a new open source matlab toolbox", Front Psychol, 3, pp.606~ (2013)
  52. Brodeur DA, "The development of selective attention in children with attention deficit hyperactivity disorder", J Abnorm Child Psychol, 29, pp.229~239 (2001)
  53. Rubia K, "Performance of children with attention deficit hyperactivity disorder(ADHD)on a test battery of impulsiveness", Child Neuropsychol, 13, pp.276~304 (2007)
  54. Heinrich H, "Time-on-task analysis using wavelet networks in an event-related potential study on attention-deficit hyperactivity disorder", Clin Neurophysiol, 112, pp.1280~1287 (2001)
  55. Missonnier P, "EEG anomalies in adult ADHD subjects performing a working memory task", Neuroscience, 241, pp.135~146 (2013)
  56. Anjana Y, "Event-related potentials study in attention deficit hyperactivity disorder", Funct Neurol, 25, pp.87~92 (2010)
  57. Sunohara GA, "Effect of methylphenidate on attention in children with attention deficit hyperactivity disorder(ADHD) : ERP evidence", Neuropsychopharmacology, 21, pp.218~228 (1999)
  58. Ritter W, "Cognition and event-related potentials : I. The relation of negative potentials and cognitive processes", Ann N Y Acad Sci, 425, pp.24~38 (1984)
  59. Snyder E, "Long-latency evoked potentials to irrelevant, deviant stimuli", Behav Biol, 16, pp.319~331 (1976)
  60. Donkers FC, "The N2 in go", no-go tasks reflects conflict monitoring not response inhibition, 2004, pp.56, 165~176
  61. Rucklidge JJ, "Gender differences in attention-deficit", hyperactivity disorder, 2010, pp.33, 357~373

관련 논문AI추천

Impulsivity in Major Depressive Disorder Patients with Suicidal Ideation: Event-related Potentials in a GoNogo TaskJaeuk Hwang, Minjae Kim, Sang-Woo Hahn, Sung-il Woo, Yeon Jung Lee대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2023 · 제21권 제4호Electrophysiological Changes Related to Childhood Trauma in Patients with Major Depressive Disorder: An Event-related Potential Study심세훈, 이호성, Heejung Yoon, Hwa-Young Lee, In Soo Heo, Ji Sun Kim, Young Joon Kwon대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2022 · 제20권 제1호Age-Related Changes in Auditory Nogo-N200 Latency in Medication-Naïve Children and Adolescents with Attention-Deficit/Hyperactivity Disorder우성일, Jeong Mi Young, Kim Ji-Sun, Kim Jung Ho, Lee Yeon Jung, Park Seoyoung대한신경정신의학회 · PSYCHIATRY INVESTIGATION2020 · 제17권 제7호Altered Auditory P300 Performance in Parents with Attention Deficit Hyperactivity Disorder OffspringChing-Lin Chu, I Hui Lee, Ko Chin Chen, Mei Hung Chi, Po See Chen, Yen Kuang Yang, Yi-Ting Hsieh대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2019 · 제17권 제4호Associations between the Mismatch-negativity Potential and Symptom Severity in Medication-naïve Children and Adolescents with Symptoms of Attention Deficit/hyperactivity Disorder이연정, Ji Sun Kim, Jung Ho Kim, Mi Young Jeong대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2020 · 제18권 제2호Differences in Electroencephalography Power and Asymmetry at Frontal Region in Young Adults with Attention-deficit/hyperactivity Disorder: A Quantitative Electroencephalography Study엄유현, 정종현, 홍승철, Ho Jun Seo, Jihye Oh, Sung-Hoon Yoon, Tae Won Kim대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2024 · 제22권 제3호

이 간행물의 다른 논문 (8건)