유용성감초추출물을 함유하는 나노에멀젼의 특성에 관한 연구
Study of the properties of oil-soluble licorice extract nano-emulsion
1
조회
0
다운로드
7
인용
0
참고문헌
키워드
초록
Over the course the past few years, many people have been attracted by functional cosmetics, pharmaceuticals and food, resulting in much study in the academic and industrial fields to enhance the stability of active ingredients under the effects of light, heat and oxygen, etc. Oil-soluble licorice extract is a functional whitening material the color stability of which depends on environmental factors such as temperature, oxygen and light. The basic purpose of cosmetics containing active ingredients is to develop formulation technologies that stabilize active compounds in the skin and to deliver effective materials selectively to the skin. In this study, the stability and skin penetration of oil-soluble licorice extract are improved by nano-emulsion. To evaluate the effect of nano-emulsion, physical properties such as droplet size and size distribution were examined. Oil-soluble licorice extract nano-emulsion was obtained using a microfluidizing process at 800bar resulting in a micelle size in the nano-emulsion solution in the 10-100nm range. According to chromameter data, the color stability of the nano-emulsion was enhanced 2 ~ 5 times compared with a general cream. The effect of skin penetration was improved, as well.
Abstract
Over the course the past few years, many people have been attracted by functional cosmetics, pharmaceuticals and food, resulting in much study in the academic and industrial fields to enhance the stability of active ingredients under the effects of light, heat and oxygen, etc. Oil-soluble licorice extract is a functional whitening material the color stability of which depends on environmental factors such as temperature, oxygen and light. The basic purpose of cosmetics containing active ingredients is to develop formulation technologies that stabilize active compounds in the skin and to deliver effective materials selectively to the skin. In this study, the stability and skin penetration of oil-soluble licorice extract are improved by nano-emulsion. To evaluate the effect of nano-emulsion, physical properties such as droplet size and size distribution were examined. Oil-soluble licorice extract nano-emulsion was obtained using a microfluidizing process at 800bar resulting in a micelle size in the nano-emulsion solution in the 10-100nm range. According to chromameter data, the color stability of the nano-emulsion was enhanced 2 ~ 5 times compared with a general cream. The effect of skin penetration was improved, as well.
참고문헌 (19)
- Beduneau A, "Active targeting of brain tumors using nanocarriers", Biomaterials, 28, pp.4947~4967 (2007)
- Torchilin VP, "Multifunctional nanocarriers", Adv. Drug Del. Rev, 58, pp.1532~1555 (2006)
- Kim CT, "Novel fabrication technology of food nanoemulsions", Korean J. Food Sci. Technol, 41, pp.33~45 (2008)
- 박주아, "소리쟁이(Rumex crispus L.) 잎 추출물의 항산화 효과 및 각질세포 보호효과", 한국인체미용예술학회지, 12(2), pp.189~198 (2011), 한국인체미용예술학회
- 김인숙, "천연항산화제의 동향과 방향에 관한 연구", 한국인체미용예술학회지, 5(2), pp.133~148 (2004)
- 모정희, "발효함초를 함유한 제형의 항균력, 안정성, 사용성에 관한 연구", 한국인체미용예술학회지, 12(4), pp.193~206 (2011), 한국인체미용예술학회
- Hansen, H. K., "Comparision of high-performance liquid chromatography and capillary electrophoresis methods for quan tative determination of glycyrrhizinic acid in pharmaceutical preparations", J. Euro Pharm. sci, 9, pp.41~49 (1999)
- Vaya J, "Antioxidant con stituents from licorice root : isolation, structure slucidation and antioxidative capacity toward LDL oxidation", Free rad ic Biol Ved, 23, pp.302~313 (1997)
- Hayashi H, "Organ specific localization of flavonoids in Glycyrrhiza glabra L", J plant Sci, 116, pp.233~238 (1996)
- 정용안, "RP-HPLC를 이용한 감초에서 Glabridin의 분리", KSBB Journal, 18(5), pp.408~411 (2003), 한국생물공학회
- Nishioka, K, "Contact allergy due to oil-soluble licorice extracts in cosmetic products", Contact Dermatitis, 40, pp.56~61 (1999)
- Yokota T, "The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation", Pigment Cell Res Dec, 11(6), pp.355~361 (1998)
- Jun S, "Antifungal activity of plant extracts against Arthrinium sacchari and Chaetomium funicola", Journal of bio science and bioengineering, 90(4), pp.226~442 (2000)
- 조완구, "나노에멀젼: 화장품을 위한 새로운 제형", 대한화장품학회지, 37(1), pp.1~21 (2011), 대한화장품학회
- 임지선, "초고압균질기를 이용한 coenzyme Q_10_ 나노에멀젼의 제조 및 저장안정성", 석사, pp.2008
- 김민정, "감초 추출물 함유 나노캡슐의 특성 및 항산화 활성", 석사, pp.2010
- P. Walstra, "Encyclopedia of emulsion technology", pp.1~ (1996), Marcel Dekker
- J.C.Vullemand, , J. Microencapsul, 8, pp.547~562 (1991)
- M. Foldvari, , Pharm.Sci. Tech. Today, 3, pp.417~425 (2000)