Antioxidant and Melanin-Reduction Effect of Mixed Extracts of Bixa orellana , Ammi majus , and Glycyrrhiza glabra
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The desire of modern people to maintain a healthy and beautiful appearance is increasing day by day along with the increasing interest in skin health and the demand for functional cosmetics. Accordingly, research on functional cosmetic materials with few side effects and excellent efficacy is being actively conducted. Therefore, this study tried to verify the antioxidant and whitening effects of the mixed extracts of Bixa orellana, Ammi majus, and Glycyrrhiza glabra, whose efficacy has been individually verified. Extracts (BAG-1~4) with different extraction methods such as steaming, fermentation, and ultrasonication were prepared for 3 types of natural plants, and antioxidant and whitening effects of these extracts were confirmed. For this purpose, antioxidant, tyrosinase activity, melanin production and stability experiments were conducted. Extracts (BAG-1~4) had no cytotoxicity, and antioxidant and whitening effects were confirmed. BAG-4 extracted by steaming and fermentation showed the best efficacy. It seems that enzymes such as lipase, protease, and amylase increase phenol components by various yeasts involved in the fermentation process, thereby improving antioxidant and melanin production inhibitory effects. It was confirmed that the three types of natural plant extracts could be used as safe and functional cosmetic materials.
Abstract
The desire of modern people to maintain a healthy and beautiful appearance is increasing day by day along with the increasing interest in skin health and the demand for functional cosmetics. Accordingly, research on functional cosmetic materials with few side effects and excellent efficacy is being actively conducted. Therefore, this study tried to verify the antioxidant and whitening effects of the mixed extracts of Bixa orellana, Ammi majus, and Glycyrrhiza glabra, whose efficacy has been individually verified. Extracts (BAG-1~4) with different extraction methods such as steaming, fermentation, and ultrasonication were prepared for 3 types of natural plants, and antioxidant and whitening effects of these extracts were confirmed. For this purpose, antioxidant, tyrosinase activity, melanin production and stability experiments were conducted. Extracts (BAG-1~4) had no cytotoxicity, and antioxidant and whitening effects were confirmed. BAG-4 extracted by steaming and fermentation showed the best efficacy. It seems that enzymes such as lipase, protease, and amylase increase phenol components by various yeasts involved in the fermentation process, thereby improving antioxidant and melanin production inhibitory effects. It was confirmed that the three types of natural plant extracts could be used as safe and functional cosmetic materials.
참고문헌 (43)
- Krutmann J, "Sun exposure : what molecular photodermatology tells us about its good and bad sides", J. Investig. Dermatol, 132, pp.976~9842 (2012)
- Gilchrest BA, "Photoaging", J. Investig. Dermatol, 133, pp.E2~6 (2013)
- Han JS, "Effects of pine needles fermentation extracts on antioxidant activity and inhibition of melanin synthesis", Korean J. Aesthetics Cosmetol, 10, pp.619~624 (2012)
- Gilchrest BA, "DNA photodamage stimulates melanogenesis and other photoprotective responses", J. Investig. Dermatol. Symp. Proc, 4, pp.35~40 (1999)
- Ito S, "Quantitative analysis of eumelanin and pheomelanin in humans, mice, and other animals : A comparative review", Pigment Cell Res, 16, pp.523~531 (2003)
- Kameyama K, "Pigment production in murine melanoma cells is regulated by tyrosinase, tyrosinase-related protein 1(TRP1), DOPA chrome tautomerase(TRP2), and a melanogenic inhibitor", J. Investig. Dermatol, 100, pp.126~131 (1993)
- Tsatmali M, "Melanocyte function and its control by melanocortin peptides", J. Histochem. Cytochem, 50, pp.125~133 (2002)
- Iwata M, "The relationship between tyrosinase activity and skin color in human foreskins", J. Investig. Dermatol, 95, pp.9~15 (1990)
- Rendon MI, "Review of skin-lightening agents", Dermatol. Surg, 31, pp.886~889 (2005)
- Curto EV, "Inhibitors of mammalian melanocyte tyrosinase : in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors", Biochem. Pharmacol, 57, pp.663~672 (1999)
- Kooyers TJ, "Toxicological aspects and health risks associated with hydroquinone in skin bleaching formula", Ned. Tijdschr. Geneeskd, 148, pp.768~771 (2004)
- Nakagawa M, "Contact allergy to kojic acid in skin care products", Contact Dermatitis, 32, pp.9~13 (1995)
- Wei CI, "Mutagenicity studies of kojic acid", Toxicol. Lett, 59, pp.213~220 (1991)
- Maeda K, "Involvement of photooxidation of melanogenic precursors in prolonged pigmentation induced by ultraviolet A", J. Investig. Dermatol, 122, pp.503~509 (2004)
- Cheng SL, "Toxicogenomics of A375 human malignant melanoma cells treated with arbutin", J. Biomed. Sci, 14, pp.87~105 (2007)
- Vilar DDA, "Traditional uses, chemical constituents, and biological activities of Bixa orellana L.: a review", ScientificWorldJournal, 2014, pp.857292~ (2014)
- Raddatz-Mota D, "Achiote (Bixa orellana L.): a natural source of pigment and vitamin E", J. Food Sci. Technol, 54, pp.1729~1741 (2017)
- Kaur R, "Glycyrrhiza glabra : a phytopharmacological review", Int. J. Pharm. Sci. Res, 4, pp.24~70 (2013)
- Gupta VK, "Antimicrobial potential of Glycyrrhiza glabra roots", J. Ethnopharmacol, 116, pp.377~380 (2008)
- Selim YA, "Anti-inflammatory new coumarin from the Ammi majus L", Org. Med. Chem. Lett, 2, pp.1~ (2012)
- Kim WY, "Steaming of ginseng at high temperature enhances biological activity", J. Nat. Prod, 63, pp.1702~1704 (2000)
- Kim GY, "Theory and practice of fermented food", pp.12~ (2009), Kyomunsa
- Lee SB, "Fermentedfood", pp.3~ (2004), Hyoil
- Lin MY, "Antioxidative ability of lactic acid bacteria", J. Agric. Food Chem, 47, pp.1460~1466 (1999)
- Utebayeva AA, "Activation of probiotics with antioxidants", Proceedings of Universities. Appl. Chem. Biotechnol, 8, pp.65~72 (2018)
- Wang YC, "Antioxidative activities of soymilk fermented with lactic acid bacteria and bifidobacteria", Food Microbiol, 23, pp.128~135 (2006)
- Fessard A, "Identification, stress tolerance, and antioxidant activity of lactic acid bacteria isolated from tropically grown fruits and leaves", Can. J. Microbiol, 62, pp.550~561 (2016)
- Re R, "Antioxidant activity applying an improved ABTS radical cation decolorization assay", Free Radic. Biol. Med, 26, pp.1231~1237 (1999)
- Yoneta A, "Ectopic expression of tyrosinase increases melanin synthesis and cell death following UVB irradiation in fibroblasts from familial atypical multiple mole and melanoma(FAMMM)patients", Melanoma Res, 14, pp.387~394 (2004)
- Imokawa G, "Isolation and characterization of tyrosinase inhibitors and their differential action on melanogenic subcelluar compartments in amelanotic and melanomas", Br. J. Dermatol, 103, pp.625~633 (1980)
- Hearing VJ, "Mammalian tyrosinase-the critical regulatory control point in melanocyte pigmentation", Int. J. Biochem, 19, pp.1141~1147 (1987)
- Park HY, "Cellular mechanisms regulating human melanogenesis", Cell. Mol. Life Sci, 66, pp.1493~1506 (2009)
- You SH, "A study on anti-oxidative, anti-inflammatory and melanin inhibitory effects of chrysanthemum sibiricum extract", J. Korean Appl. Sci. Technol, 33, pp.762~770 (2016)
- Tarangini K, "Production of melanin by soil microbial isolate on fruit waste extract : two step optimization of key parameters", Biotechnol. Rep, 4, pp.139~146 (2014)
- Huang HC, "Inhibitory effects of adlay extract on melanin production and cellular oxygen stress in B16F10 melanoma cells", Int. J. Mol. Sci, 15, pp.16665~16679 (2014)
- Klein A, "Prolonged stabilization of platinum-resistant ovarian cancer in a single patient consuming a fermented soy therapy", Gynecol. Oncol, 100, pp.205~209 (2006)
- Park MR, "Change of total polyphenol content of fermented Gastrodia elata Blume and radical scavenging", Korean J. Plant Resour, 25, pp.379~386 (2012)
- Choi EY, "The effect of fermented Mori Cortex extracts on antioxidant activity and melanin inhibitory activity", J. Korean Soc. Aesthetics, 17, pp.495~499 (2011)
- Dey TB, "Antioxidant phenolics and their microbial production by submerged and solid-state fermentation process : A review", Trends Food Sci. Technol, 53, pp.60~74 (2016)
- Hur SJ, "Effect of fermentation on the antioxidant activity in plant-based foods", Food Chem, 160, pp.346~356 (2014)
- Park EH, "Antimelanogenic effects of Inula britannica flower petal extract fermented by Lactobacillus plantarum KCCM 11613P", J. Zhejiang Univ. Sci. B, 18, pp.816~ (2017)
- Kim SH, "Enhancement of TRP gene expression and UV absorption by bioconverted chestnut inner shell extracts using Lactiplantibacillus plantarum", Molecules, 27, pp.4940~ (2022)
- Feng N, "Debate : Could the litchi pericarp oligomeric procyanidins bioconverted by Lactobacillus plantarum increase the inhibitory capacity on advanced glycation end products?", Front. Nutr, 9, pp.961078~ (2022)