30종 에센셜오일Gardnerella vaginalis 및 Lactobacillus vaginalis에 미치는 항균효과 연구
Antimicrobial Effects on 30 Types of Essential Oils Gardnerella vaginalis and Lactobacillus vaginalis
4
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Bacterial vaginosis (BV) is one of common diseases for women of childbearing age. Gardnerella vaginalis is often found in such vaginal infection, but it is not always possible to experience symptoms. This condition happens when the balance of microbiota which is detected in the vagina of healthy women of childbearing age breaks. It appears that the direct cause of the problem is a decrease in lactobacillus which keeps the vaginal pH acidic by producing lactic acid. The vagina is a muscular tube linked with mucous membranes. It is higher than any other skin parts in terms of permeability. Therefore, it is important to closely check the ingredients of frequently used feminine washes. This study attempted to investigate the effects of 30 different essential oils on Gardnerella vaginalis and examine if they obstruct the maintenance of Lactobacillus vaginalis among those which keep the vaginal environment slightly acidic, considering the fact that they are used to stay protected from external aggressors. Regarding disc diffusion, Gardnerella vaginalis was compared to Lactobacillus vaginalis in terms of the size of the growth inhibition clear zone. In addition, minimum inhibitory concentration (MIC) was measured, using the serial dilution technique, confirming the antimicrobial effects of Gardnerella vaginalis. The goal of this study is to provide basic data which are needed in developing safer feminine washes by finding essential oils which have no harm on the growth of Lactobacillus vaginalis.
Abstract
Bacterial vaginosis (BV) is one of common diseases for women of childbearing age. Gardnerella vaginalis is often found in such vaginal infection, but it is not always possible to experience symptoms. This condition happens when the balance of microbiota which is detected in the vagina of healthy women of childbearing age breaks. It appears that the direct cause of the problem is a decrease in lactobacillus which keeps the vaginal pH acidic by producing lactic acid. The vagina is a muscular tube linked with mucous membranes. It is higher than any other skin parts in terms of permeability. Therefore, it is important to closely check the ingredients of frequently used feminine washes. This study attempted to investigate the effects of 30 different essential oils on Gardnerella vaginalis and examine if they obstruct the maintenance of Lactobacillus vaginalis among those which keep the vaginal environment slightly acidic, considering the fact that they are used to stay protected from external aggressors. Regarding disc diffusion, Gardnerella vaginalis was compared to Lactobacillus vaginalis in terms of the size of the growth inhibition clear zone. In addition, minimum inhibitory concentration (MIC) was measured, using the serial dilution technique, confirming the antimicrobial effects of Gardnerella vaginalis. The goal of this study is to provide basic data which are needed in developing safer feminine washes by finding essential oils which have no harm on the growth of Lactobacillus vaginalis.
참고문헌 (24)
- K. Peebles, "High global burden and costs of bacterial vaginosis－A systematic review and meta-analysis", Sexually Transmitted Diseases, 46(5), pp.304~314 (2019)
- 김정아, "세균성 질증 치료의 주요 표적세균(Gardnerella vaginalis)에 대한 프로바이오틱스와 항생제 효과", 박사, pp.2015
- 김계현, "Affirm VPIII, Papanicolaou 도말 검사 및 Gram 염색에서의 Trichomonas vaginalis, Gardnerella vaginalis 및 Candida spp. 검출", 대한임상미생물학회지, 5(3), pp.104~109 (2012)
- S. Swidsinski, "Bacterial Vaginosis—Vaginal Polymicrobial Biofilms and Dysbiosis", Deutsches Arzteblatt ̈International, 120(20), pp.347~354 (2023)
- D. A. Eschenbach, "Bacterial vaginosis and anaerobes in obstetric-gyneco—Logic infection", Clinical Infectious Diseases, 16(4), pp.282~287 (1993)
- E. Amabebe, "The vaginal microenvironment—the physiologic role of Lactobacilli", Frontiers in Medicine, 5, pp.181~ (2018)
- P. Mirmonsef, "A comparison of lower genital tract glycogen and lactic acid levels in women and macaques—Implications for HIV and SIV susceptibility", AIDS Research and Human Retroviruses, 28(1), pp.76~81 (2012)
- R. Vazquez-Munoz, "Anticandidal activities by lactobacillus species—An update on mechanisms of action", Frontiers in Oral Health, 2, pp.689382~ (2021)
- S. E. Jang, "Lactobacillus rhamnosus HN001 and lactobacillus acidophilus La-14 attenuate Gardnerella vaginalis-Infected bacterial vaginosis in mice", Nutrients, 9(7), pp.53~ (2017)
- 황영식, "세균성질증의 한방외치요법에 대한 무작위 대조군 비교 임상시험중심의 고찰", 대한한방부인과학회지, 32(2), pp.50~70 (2019)
- H. Kim, "In vivo confirmation of the antimicrobial effect of probiotic candidates against Gardnerella vaginalis", Microorganisms, 9, pp.1690~ (2021)
- L. A. Chacra, "Bacterial vaginosis What do we currently －know?", Frontiers in Cellular and Infection Microbiology, 11, pp.672429~ (2022)
- 이설희, "에센셜 오일을 사용한 발반사요법이 스트레스, 주의지수 뇌파에 미치는 영향", 한국인체미용예술학회지, 12(3), pp.119~129 (2011)
- 배민규, "이너뷰티를 위한 라벤더 에센셜 오일의 미용관련 생리활성 평가", 한국인체미용예술학회지, 22(1), pp.319~335 (2021)
- 김채수, "질염(Vaginitis) 치료에 있어서 Aroma blending oils과 항진균제 및 항생제와 비교에 관한 연구", 석사, pp.2003
- 허선화, "아로마테라피에 적용되는 블렌딩오일의 성분특성에 따른 분류와 효과에 대한 메타분석", 박사, pp.2019
- M. Perricone, "Bioactivity of essential oils—A review on their interaction with food components", Microbiology, 6(76), pp.1~7 (2015)
- 배민규, "티트리 에센셜 오일의 항산화활성 및 피부 주름개선 효과", 뷰티산업연구, 14(1), pp.67~81 (2020)
- 박상희, "식물성 천연물로부터 분리한 질염 유발 병원균의 억제 물질에 대한 특성연구", 석사, pp.2020
- 김정숙, "여성청결제 사용 실태와 만족도에 대한 연구", 대한피부미용학회지, 13(2), pp.267~274 (2015)
- "화장품법, 행정규칙 별표1. 화장품의 유형과 유형별⋅함유 성분별 사용할 때의 주의사항표시 문구(제2조 관련)", ~
- 김유진, "QFD기법을 이용한 여성청결제의 품질개선에 관한 연구", 석사, pp.2016
- 2020년 화장품산업분석보고서, "한국보건산업진흥원", 64~ (2020)
- M. MehriArdestani, "Evaluation of antimicrobial activity of Trachyspermum ammi(L. )sprague essential oil and its active constituent, thymol, against vaginal pathogens", Traditional and Integrative Medicine, 5(2), pp.49~58 (2020)