유칼립투스 정유와 Eucapytol의 Candida albicans에 대한 항 진균 효과
Antifungal Activity of the Essential oil from Eucalyptus and Eucapytol against Candida albicans
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초록
Background: Candida albicans is a member of the normal flora of the skin, mucous membranes and gastrointestinal tract. Vaginal candidiasis remains a significant problem in women of childbearing age, majority of the cases are caused by C. albicans and recurrence is common in spite of topical treatment. Objective: The purpose of this study was to develop the antifungal agent from the medicinal herbs traditionally used in Korea. Method: In this study, the essential oil of eucalyptus, cedar wood, clary sage, orange sweet and eucapytol were examined for antifungal activities against C. albicans. Results: 1. Eucalyptus essential oil and eucapytol showed antifungal activity against C. albicans. 2. Minimal inhibitory concentration (MIC) of Eucapytol against eight strains and standard strains was 12.5 μl/ml and 6.25 μl/ml against two strains. 3. MIC of eucapytol was 25 μl/ml against eight strains and 50 μl/ml against two. Conclusion: Eucalyptus essential oil and eucalytol could be a candidate for a new antifungal agent for candidiasis and other fungal diseases.
Abstract
Background: Candida albicans is a member of the normal flora of the skin, mucous membranes and gastrointestinal tract. Vaginal candidiasis remains a significant problem in women of childbearing age, majority of the cases are caused by C. albicans and recurrence is common in spite of topical treatment. Objective: The purpose of this study was to develop the antifungal agent from the medicinal herbs traditionally used in Korea. Method: In this study, the essential oil of eucalyptus, cedar wood, clary sage, orange sweet and eucapytol were examined for antifungal activities against C. albicans. Results: 1. Eucalyptus essential oil and eucapytol showed antifungal activity against C. albicans. 2. Minimal inhibitory concentration (MIC) of Eucapytol against eight strains and standard strains was 12.5 μl/ml and 6.25 μl/ml against two strains. 3. MIC of eucapytol was 25 μl/ml against eight strains and 50 μl/ml against two. Conclusion: Eucalyptus essential oil and eucalytol could be a candidate for a new antifungal agent for candidiasis and other fungal diseases.
참고문헌 (29)
- Smith EB., "History of antifungals", J Am Acad Dermatol, 23, pp.776~778 (1990)
- Herbrecht R, "Management of systemic fungal infections: alternatives to itraconazole", Antimicrobial Chemotherapy, 56(S1), pp.i139~i148 (2005)
- Gupta AK, "Terbinafine therapy may be associated with the development of psoriasis de novo or its exacerbation; four case reports and a review of drug-induced psoriais", J Am Acad Deramtol, 36, pp.858~862 (1997)
- Wach F, "Severe erythema anulare centrifugum-like psoriatic drug eruption induced by terbinafine", Arch Dermatol, 131, pp.960~961 (1995)
- Gupta AK, "Hypersensitivity reaction to terbinafine", J Am Acad Dermatol, 36, pp.1018~1019 (1997)
- Duoin N, "Acute generalized erythematous pustulosis induced by terbinafine", Arch Dermatol, 132, pp.123~1254 (1996)
- Bennet ML, "General pustular eruptions associated with oral terbinafine Int J Dermatol", 38, pp.596~600 (1999)
- Vivas S, "Acute hepatitis associated with terbinafine", Gastroenterol Hepatol, 20, pp.456~458 (1997)
- Cox PA., "The ethnobotanical approach to drug discovery: Strengths and limitations in: Ethnobotany and the search for new drugs", pp.25~41 (1994), Wiley
- Grayer RJ, "Review article No. 92. A survey of antifungal compounds from higher plants", Phytochem, 37, pp.19~42 (1994)
- Mehmet Musa Ozcan, "Comparative Essential Oil Composition and Antifungal Effect of Bitter Fennel (Foeniculum vulgare ssp. piperitum) Fruit Oils Obtained During Different Vegetation", Journal of Medicinal Food, 9(4), pp.552~561 (2006), 한국식품영양과학회
- Mimica-Dukic N, "Essential oil composition antifungal activity of Foeniculum vulgare mill obtained by different conditions", Phytother Res, 17(4), pp.368~371 (2003)
- Ken-ichi Fujita, "Anethole, a potent antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agent", Phytother Res, 1, pp.47~50 (2007)
- Adetumbi MA, "Allium sativum (garlic)--a natural antibiotic", Med Hypothesis, 12(3), pp.227~237 (1983)
- Shahi SK, "Broad spectrum herbal therapy against superficial fungal infections", Skin Pharmacol Appl Skin Physiol, 13(1), pp.60~64 (2000)
- Rai MK, "In vitro susceptibility of opportunistic Fusarium spp. to essential oils", Mycoses, 42(1), pp.97~101 (1999)
- Pattnaik S, "Antibacterial and antifungal activity of ten essential oils in vitro", Microbios, 86, pp.237~246 (1996)
- Ramezani H., "Fungicidal activity of volatile oil from eucalyptus Citriodora Hook. against Alternaria triticina", Commun Agric Appl Biol Sci, 71(3), pp.909~914 (2006)
- Kim SJ, "Antimicrobial substances in Leek (Alliumtuberosum)", Kor J Food Sci Technol, 28(3), pp.604~608 (1996)
- Kumar M, "Sensitivity of food pathogens to garlic (Allium sativum)", J Appl Microbiol, 84(2), pp.213~215 (1998)
- Lee HY, "Antimicrobial activity of Ulmus pumila L. extract", Kor J Appl Microbiol Biotechnol, 20(1), pp.1~5 (1996)
- Pattnaik S, "Effect of essential oils on the viability and morphology of Escheriachia coli (SP-11)", Microbios, 84(340), pp.195~199 (1998)
- Rai MK, "Invitro susceptibility of opportunistic Fusarium spp. to esential oils", Mycoses, 42(1), pp.97~101 (1999)
- Shahi SK, "Broad spectrum herbal therapy against superficial fungal infections", Skin Pharmacol Physiol, 13(1), pp.6064~ (2000)
- Lopes-Lutz D, "Screeing of chemical composition, antimicrobial and antioxidant activities of Artemisia essential oils", Phytochemistry, 69(8), pp.1732~1738 (2008)
- Maetha Windholz, "Otterbein The MerckIndex An Encyclopedia of Chemicals, Drugs and Biologicals. 3rd ed", pp.974~ (1983), Rahway. Merck & CO., Inc
- Boland DL, "Eucalyptus Leafoils", 6~, pp.ISBN 09006-5-69-6 (1991)
- Yang YC, "Ovicidal and adulticidal activity of Eucalyptus globulus leaf oil terpenoids against Pediculus humanus capitis (Anoplura: Pediculidae)", J Agric Food Chem, 52(9), pp.2507~2511 (2004)
- Kehrl W, "Therapy for acute nonprulent rhinosinusitis with cineol; results of a double-blind, randomized, placebo-controlled trials", Lsryngoscope, 114, pp.738~742 (2004)