白芷 추출물이 DNFB에 의하여 유발된 생쥐의 접촉피부염에 미치는 영향
Effects of Angelicae Dahuricae Radix on 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis in mice
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초록
In the theory of Korean medicine, Angelicae Dahuricae Radix (ADR) can expel wind and relieve exterior syndrome, and eliminate dampness. Recently, ADR has been reported to have possibilities as anti-inflammatory agent and cosmetics. The purpose of this study is to evaluate the efficacy of ADR on contact dermatitis (CD). In order to investigate the anti-inflammatory effects of ADR on CD, we investigated the effects of ADR on ear thickness, ear weight, skin lesion and histopathological changes in mice with CD induced by 1-fluoro-2,4-dinitrofluorobenzene (DNFB). In addition, the effect on spleen weight was also measured. In our results, topical application of ADR lowered ear thickness and weight respectively. ADR treatment also improved skin lesions such as erythema and scale. In the histopathological observation, ADR-treated group showed diminished epidermal hyperplasia and immune cell infiltration in inflammed tissues compared to those of non-treated control group. In conclusion, These data suggest that ADR has anti-inflammatory action in inflammed skin tissue, resulting in improving skin lesion and histopathological abnormalities of CD.
Abstract
In the theory of Korean medicine, Angelicae Dahuricae Radix (ADR) can expel wind and relieve exterior syndrome, and eliminate dampness. Recently, ADR has been reported to have possibilities as anti-inflammatory agent and cosmetics. The purpose of this study is to evaluate the efficacy of ADR on contact dermatitis (CD). In order to investigate the anti-inflammatory effects of ADR on CD, we investigated the effects of ADR on ear thickness, ear weight, skin lesion and histopathological changes in mice with CD induced by 1-fluoro-2,4-dinitrofluorobenzene (DNFB). In addition, the effect on spleen weight was also measured. In our results, topical application of ADR lowered ear thickness and weight respectively. ADR treatment also improved skin lesions such as erythema and scale. In the histopathological observation, ADR-treated group showed diminished epidermal hyperplasia and immune cell infiltration in inflammed tissues compared to those of non-treated control group. In conclusion, These data suggest that ADR has anti-inflammatory action in inflammed skin tissue, resulting in improving skin lesion and histopathological abnormalities of CD.
참고문헌 (19)
- 박지혜, "미용사의 직업성 피부질환: 첩포검사 결과에 대한 고찰", 대한피부과학회지, 44(6), pp.669~674 (2006), 대한피부과학회
- 배유인, "접촉피부염 환자에서 최근 5년간 표준항원 첩포시험 성적", 대한피부과학회지, 47(11), pp.1227~1235 (2009), 대한피부과학회
- Wen M. C., "Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma", J Allergy Clin Immunol, 116(3), pp.517~524 (2005)
- Kim E.H., "A literature study on major symptoms of atopic dermatitis", pp.2009
- The textbook compilation committee of Korean herbology, "Bonchohak", pp.165~166 (2010), Younglimsa
- Lee M. Y., "Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1", Food Chem Toxicol, 49(4), pp.829~837 (2011)
- Luo K. W., "Anticancer effects of imperatorin isolated from Angelica dahurica: induction of apoptosis in HepG2 cells through both death-receptor- and mitochondria-mediated pathways", Chemotherapy, 57(6), pp.449~459 (2011)
- Cao Y., "Antioxidant effect of imperatorin from Angelica dahurica in hypertension via inhibiting NADPH oxidase activation and MAPK pathway", J Am Soc Hypertens, 8(8), pp.527~536 (2014)
- Lee M. Y., "Anti-inflammatory activity of Angelica dahurica ethanolic extract on RAW264.7 cells via upregulation of heme oxygenase-1", Food Chem Toxicol, 49(5), pp.1047~1055 (2011)
- Cho Y. H., "New cosmetic agents for skin whitening from Angelica dahurica", J Cosmet Sci, 57(1), pp.11~21 (2006)
- Lee H., "Angelicae Dahuricae Radix Inhibits Dust Mite Extract-Induced Atopic Dermatitis-Like Skin Lesions in NC", Nga Mice, 2012, pp.2012, 743075~
- Kim H., "Effect of Sophora flavescens Aiton extract on degranulation of mast cells and contact dermatitis induced by dinitrofluorobenzene in mice", J Ethnopharmacol, 142(1), pp.253~258 (2012)
- Hopkins J. E., "Selective haptenation of cellular or extracellular protein by chemical allergens: association with cytokine polarization", Chem Res Toxicol, 18(2), pp.375~381 (2005)
- KDA Textbook Editing Board, "Dermatology 5th edition", pp.165~167 (2008), Ryo Moon Gak
- Kim H., "Anti-inflammatory activities of Dictamnus dasycarpus Turcz., root bark on allergic contact dermatitis induced by dinitrofluorobenzene in mice", J Ethnopharmacol, 149(2), pp.471~477 (2013)
- Sato K., "Involvement of TNF-α Converting Enzyme in the Development of Psoriasis-Like Lesions in a Mouse Model", PLoS One, 9(11), pp.e112408~ (2014)
- Sebastiani S., "The role of chemokines in allergic contact dermatitis", Arch Dermatol Res, 293(11), pp.552~559 (2003)
- Yang., "ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow", Blood, 106(2), pp.584~592 (2005)
- Kim M., "Anti-inflammatory effects of Cryptotympana atrata Fabricius slough shed on contact dermatitis induced by dinitrofluorobenzene in mice", Pharmacogn Mag, 10(2), pp.37~382 (2014)